Drug General Information |
Drug ID |
D06TLL
|
Former ID |
DIB019926
|
Drug Name |
Go 6983
|
Synonyms |
Go 6983; Goe 6983; Go-6893
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Drug Type |
Small molecular drug
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Indication |
Discovery agent
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Investigative |
[534191]
|
Structure |
|
Download
2D MOL
|
Formula |
C26H26N4O3
|
InChI |
InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
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InChIKey |
LLJJDLHGZUOMQP-UHFFFAOYSA-N
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PubChem Compound ID |
|
PubChem Substance ID |
7351422, 7980335, 8152221, 24894916, 26756888, 26758818, 29222631, 53790882, 53800747, 56374684, 57244621, 57321841, 76769069, 91704242, 99302683, 103102818, 103568539, 104303692, 117623368, 125333702, 128505811, 135329656, 135698479, 140926863, 160657155, 162009844, 162247879, 162786638, 163688025, 172821376, 174006382, 175607410, 178101880, 179113918, 204371830, 208264963, 210274933, 210280570, 223705239, 227866179, 241375861, 250136921, 252156412, 252457813, 252471838
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Target and Pathway |
Target(s) |
Protein kinase C gamma type |
Target Info |
Inhibitor |
[534191]
|
Protein kinase C, alpha type |
Target Info |
Inhibitor |
[534191]
|
Protein kinase C, beta type |
Target Info |
Inhibitor |
[534191]
|
mRNA of PKC-delta |
Target Info |
Inhibitor |
[534191]
|
mRNA of PKC-zeta |
Target Info |
Inhibitor |
[534191]
|
KEGG Pathway
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MAPK signaling pathway
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ErbB signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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HIF-1 signaling pathway
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Phosphatidylinositol signaling system
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Sphingolipid signaling pathway
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mTOR signaling pathway
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Vascular smooth muscle contraction
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Wnt signaling pathway
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VEGF signaling pathway
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Focal adhesion
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Tight junction
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Gap junction
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Natural killer cell mediated cytotoxicity
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Fc gamma R-mediated phagocytosis
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Leukocyte transendothelial migration
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Circadian entrainment
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Long-term potentiation
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Retrograde endocannabinoid signaling
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Glutamatergic synapse
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Cholinergic synapse
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Serotonergic synapse
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GABAergic synapse
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Dopaminergic synapse
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Long-term depression
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Inflammatory mediator regulation of TRP channels
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Insulin secretion
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Melanogenesis
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Thyroid hormone synthesis
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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Aldosterone-regulated sodium reabsorption
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Endocrine and other factor-regulated calcium reabsorption
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Salivary secretion
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Gastric acid secretion
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Pancreatic secretion
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Amphetamine addiction
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Morphine addiction
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Vibrio cholerae infection
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African trypanosomiasis
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Amoebiasis
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Hepatitis B
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Pathways in cancer
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Proteoglycans in cancer
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MicroRNAs in cancer
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Glioma
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Non-small cell lung cancer
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Choline metabolism in cancerhsa04010:MAPK signaling pathway
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PI3K-Akt signaling pathway
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Adrenergic signaling in cardiomyocytes
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Fc epsilon RI signaling pathway
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GnRH signaling pathway
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Pathogenic Escherichia coli infection
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Influenza A
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Chemokine signaling pathway
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NF-kappa B signaling pathway
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B cell receptor signaling pathway
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Carbohydrate digestion and absorption
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Leishmaniasis
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Choline metabolism in cancerhsa04062:Chemokine signaling pathway
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Neurotrophin signaling pathway
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Estrogen signaling pathway
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Type II diabetes mellitushsa04015:Rap1 signaling pathway
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Endocytosis
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Hippo signaling pathway
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Platelet activation
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Insulin signaling pathway
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Type II diabetes mellitus
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NetPath Pathway
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IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
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PANTHER Pathway
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Alpha adrenergic receptor signaling pathway
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Alzheimer disease-amyloid secretase pathway
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Angiogenesis
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Apoptosis signaling pathway
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EGF receptor signaling pathway
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Endothelin signaling pathway
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FGF signaling pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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VEGF signaling pathway
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Wnt signaling pathway
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5HT2 type receptor mediated signaling pathway
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Histamine H1 receptor mediated signaling pathway
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Oxytocin receptor mediated signaling pathway
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Thyrotropin-releasing hormone receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
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PDGF signaling pathway
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Thyrotropin-releasing hormone receptor signaling pathway
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin
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CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
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B cell activation
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Inflammation mediated by chemokine and cytokine signaling pathway
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Metabotropic glutamate receptor group I pathway
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CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
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Pathway Interaction Database
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Endothelins
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Thromboxane A2 receptor signaling
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Retinoic acid receptors-mediated signaling
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IL8- and CXCR2-mediated signaling events
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PAR1-mediated thrombin signaling events
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IL8- and CXCR1-mediated signaling eventsendothelinpathway:Endothelins
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TCR signaling in naï
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Canonical NF-kappaB pathway
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Signaling events regulated by Ret tyrosine kinase
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TCR signaling in naï
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mTOR signaling pathway
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Ras signaling in the CD4+ TCR pathway
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ErbB1 downstream signaling
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Syndecan-4-mediated signaling events
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ATF-2 transcription factor network
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PDGFR-beta signaling pathway
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2
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a6b1 and a6b4 Integrin signaling
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IL8- and CXCR1-mediated signaling events
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Regulation of Ras family activation
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Downstream signaling in naï
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Fc-epsilon receptor I signaling in mast cells
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IL2-mediated signaling events
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JNK signaling in the CD4+ TCR pathway
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Endothelins
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LPA receptor mediated events
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IGF1 pathway
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Ceramide signaling pathway
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IFN-gamma pathway
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IL6-mediated signaling events
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Hedgehog signaling events mediated by Gli proteins
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Syndecan-2-mediated signaling events
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Validated transcriptional targets of TAp63 isoforms
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p53 pathway
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Trk receptor signaling mediated by the MAPK pathway
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Trk receptor signaling mediated by PI3K and PLC-gamma
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Alpha-synuclein signalingrhoa_pathway:RhoA signaling pathway
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Insulin Pathway
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Noncanonical Wnt signaling pathway
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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CDC42 signaling events
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IL1-mediated signaling events
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CXCR4-mediated signaling events
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TNF receptor signaling pathway
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IL2 signaling events mediated by PI3K
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p75(NTR)-mediated signaling
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amb2 Integrin signaling
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Neurotrophic factor-mediated Trk receptor signaling
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Nephrin/Neph1 signaling in the kidney podocyte
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Insulin-mediated glucose transport
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast Cells
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Activation of PKC through G protein coupled receptorPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Reactome
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Calmodulin induced events
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Disinhibition of SNARE formation
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Trafficking of GluR2-containing AMPA receptors
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G alpha (z) signalling events
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WNT5A-dependent internalization of FZD4
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Response to elevated platelet cytosolic Ca2+R-HSA-111933:Calmodulin induced events
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Regulation of KIT signaling
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EGFR Transactivation by Gastrin
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Inactivation, recovery and regulation of the phototransduction cascade
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Syndecan interactions
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Acetylcholine regulates insulin secretion
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Ca2+ pathway
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Depolymerisation of the Nuclear Lamina
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HuR (ELAVL1) binds and stabilizes mRNA
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VEGFR2 mediated cell proliferation
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Response to elevated platelet cytosolic Ca2+R-HSA-114516:Disinhibition of SNARE formation
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Activation of NF-kappaB in B cells
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Response to elevated platelet cytosolic Ca2+R-HSA-111465:Apoptotic cleavage of cellular proteins
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Effects of PIP2 hydrolysis
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DAG and IP3 signaling
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Role of phospholipids in phagocytosis
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CLEC7A (Dectin-1) signaling
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Interferon gamma signalingR-HSA-114604:GPVI-mediated activation cascade
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TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
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WikiPathways
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Calcium Regulation in the Cardiac Cell
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
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MAPK Signaling Pathway
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Wnt Signaling Pathway Netpath
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G Protein Signaling Pathways
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Myometrial Relaxation and Contraction Pathways
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DAG and IP3 signaling
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Signaling Pathways in Glioblastoma
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miRs in Muscle Cell Differentiation
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Opioid Signalling
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Response to elevated platelet cytosolic Ca2+WP673:ErbB Signaling Pathway
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Insulin Signaling
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EGF/EGFR Signaling Pathway
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Kit receptor signaling pathway
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Transcriptional activation by NRF2
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Human Complement System
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Cardiac Hypertrophic Response
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Syndecan interactions
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Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
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Signaling by SCF-KIT
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Gastrin-CREB signalling pathway via PKC and MAPK
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T-Cell Receptor and Co-stimulatory Signaling
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Alpha 6 Beta 4 signaling pathway
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Oncostatin M Signaling Pathway
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Corticotropin-releasing hormone
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AGE/RAGE pathway
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Pathogenic Escherichia coli infection
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Endothelin Pathways
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Regulation of Microtubule Cytoskeleton
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FSH signaling pathway
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Response to elevated platelet cytosolic Ca2+
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Integration of energy metabolism
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TOR SignalingWP536:Calcium Regulation in the Cardiac Cell
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Signaling by the B Cell Receptor (BCR)
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B Cell Receptor Signaling Pathway
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MicroRNAs in cardiomyocyte hypertrophy
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Physiological and Pathological Hypertrophy of the HeartWP69:TCR Signaling Pathway
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Type II interferon signaling (IFNG)
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IL-6 signaling pathway
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BDNF signaling pathway
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GPCR downstream signaling
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Effects of PIP2 hydrolysis
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Apoptotic execution phase
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Type II diabetes mellitusWP536:Calcium Regulation in the Cardiac Cell
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Signaling by TGF-beta Receptor Complex
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Allograft Rejection
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TNF alpha Signaling Pathway
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IL-1 signaling pathway
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GPVI-mediated activation cascade
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Type II diabetes mellitus
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References |
Ref 534191 | Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80. |
Ref 534191 | Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80. |