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Global Patent Index - EP 2456460 A4

EP 2456460 A4 20130220 - METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH AVB5 INTEGRIN

Title (en)

METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH AVB5 INTEGRIN

Title (de)

VERFAHREN UND ZUSAMMENSETZUNGEN ZUR BEHANDLUNG UND PRÄVENTION VON MIT AVB5-INTEGRIN ASSOZIIERTEN KRANKHEITEN

Title (fr)

PROCÉDÉS ET COMPOSITIONS DESTINÉS À TRAITER ET À PRÉVENIR DES MALADIES ASSOCIÉES À L'INTÉGRINE V 5

Publication

EP 2456460 A4 20130220 (EN)

Application

EP 10803008 A 20100726

Priority

  • US 22841609 P 20090724
  • US 2010043211 W 20100726

Abstract (en)

[origin: WO2011011775A1] The present invention provides compositions and methods for treating and preventing disease associated with avß5 integrin by blocking binding to avß5 integrin. In particular, antibodies specific for avß5 integrin are useful for preventing, treating, and reversing sepsis.

IPC 8 full level

A61K 39/00 (2006.01)

CPC (source: EP KR US)

A61K 9/0019 (2013.01 - KR); A61K 39/395 (2013.01 - KR); A61K 39/3955 (2013.01 - KR); A61P 7/00 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/14 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); C07K 16/2839 (2013.01 - EP KR US); C07K 16/2848 (2013.01 - EP KR US); A61K 2039/505 (2013.01 - EP US); C07K 2317/76 (2013.01 - EP US)

Citation (search report)

  • [XI] US 2005226865 A1 20051013 - SHEPPARD DEAN [US], et al
  • [A] GEORGE SU ET AL: "Integrin -alpha-v-beta-5 Regulates Lung Vascular Permeability and Pulmonary Endothelial Barrier Function", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 36, no. 3, 1 March 2007 (2007-03-01), pages 377 - 386, XP008150128, ISSN: 1044-1549, [retrieved on 20061101], DOI: 10.1165/RCMB.2006-0238OC
  • [A] MCCAFFREE D R ET AL: "ROLE OF PULMONARY EDEMA IN THE ACUTE PULMONARY RESPONSE TO SEPSIS", JOURNAL OF APPLIED PHYSIOLOGY RESPIRATORY ENVIRONMENTAL AND EXERCISE PHYSIOLOGY, vol. 50, no. 6, 1981, pages 1198 - 1205, XP009166126, ISSN: 0161-7567
  • See references of WO 2011011775A1

Citation (examination)

  • MICHAEL T. GANTER ET AL: "Role of Small GTPases and [alpha]v[beta]5 Integrin in Pseudomonas aeruginosa -Induced Increase in Lung Endothelial Permeability", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY., vol. 40, no. 1, 1 January 2009 (2009-01-01), NEW YORK, NY, US, pages 108 - 118, XP055380245, ISSN: 1044-1549, DOI: 10.1165/rcmb.2007-0454OC
  • DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; April 2008 (2008-04-01), LANGE MATTHIAS ET AL: "Assessment of vascular permeability in an ovine model of acute lung injury and pneumonia-induced Pseudomonas aeruginosa sepsis.", Database accession no. NLM18379256
  • S. T. MICEK ET AL: "Pseudomonas aeruginosa Bloodstream Infection: Importance of Appropriate Initial Antimicrobial Treatment", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 49, no. 4, 25 March 2005 (2005-03-25), pages 1306 - 1311, XP055380265, ISSN: 0066-4804, DOI: 10.1128/AAC.49.4.1306-1311.2005 & LANGE MATTHIAS ET AL: "Assessment of vascular permeability in an ovine model of acute lung injury and pneumonia-induced Pseudomonas aeruginosa sepsis.", CRITICAL CARE MEDICINE APR 2008, vol. 36, no. 4, April 2008 (2008-04-01), pages 1284 - 1289, ISSN: 1530-0293

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

Designated extension state (EPC)

BA ME RS

DOCDB simple family (publication)

WO 2011011775 A1 20110127; AU 2010275367 A1 20120202; AU 2010275367 B2 20150903; BR 112012001463 A2 20160315; CA 2767409 A1 20110127; CA 2767409 C 20181030; CN 102481347 A 20120530; EP 2456460 A1 20120530; EP 2456460 A4 20130220; IL 217406 A0 20120229; IL 217406 A 20160229; IN 303DEN2012 A 20150508; JP 2013500269 A 20130107; JP 5755647 B2 20150729; KR 101752515 B1 20170629; KR 20120052312 A 20120523; US 10087252 B2 20181002; US 2012328604 A1 20121227

DOCDB simple family (application)

US 2010043211 W 20100726; AU 2010275367 A 20100726; BR 112012001463 A 20100726; CA 2767409 A 20100726; CN 201080033367 A 20100726; EP 10803008 A 20100726; IL 21740612 A 20120105; IN 303DEN2012 A 20120111; JP 2012521872 A 20100726; KR 20127003723 A 20100726; US 201013386323 A 20100726