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Global Patent Index - EP 1516055 A4

EP 1516055 A4 20070808 - FIBER SHAFT MODIFICATIONS FOR EFFICIENT TARGETING

Title (en)

FIBER SHAFT MODIFICATIONS FOR EFFICIENT TARGETING

Title (de)

FASERSCHAFTMODIFIKATIONEN FÜR EFFIZIENTES ZIELEN

Title (fr)

MODIFICATIONS DE TIGE FIBRE POUR UN CIBLAGE EFFICACE

Publication

EP 1516055 A4 20070808 (EN)

Application

EP 03732097 A 20030124

Priority

  • US 0302295 W 20030124
  • US 35038802 P 20020124
  • US 39196702 P 20020626

Abstract (en)

[origin: WO03062400A2] Provided are adenoviral vectors and the production of such vectors. In particular, fiber shaft modifications for efficient targeting of adenoviral vectors are provided. The fiber shaft modifications can be combined with other modifications, such as fiber knob and/or penton modifications, to produce fully ablated detargeted adenoviral vectors. A scale-up method for the propagation of detargeted adenoviral vectors is also provided.

[origin: WO03062400A2] Provided are adenoviral vectors and the production of such vectors. In particular, fiber shaft modifications for efficient targeting of adenoviral vectors are provided. The fiber shaft modifications can be combined with other modifications, such as fiber knob and/or penton modifications, to produce fully ablated (detargeted) adenoviral vectors. A scale−up method for the propagation of detargeted adenoviral vectors is also provided.

IPC 1-7

C12N 15/63; C12N 15/11; C12N 15/85; C12N 7/00; C12N 15/00; C07K 14/00; A23J 1/00; C12P 21/00

IPC 8 full level

A61K 35/761 (2015.01); C07K 14/075 (2006.01); C12N 5/08 (2006.01); C12N 7/02 (2006.01); C12N 15/861 (2006.01)

CPC (source: EP US)

A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/005 (2013.01 - EP US); C12N 7/00 (2013.01 - EP US); C12N 15/86 (2013.01 - EP US); C12N 2710/10322 (2013.01 - EP US); C12N 2710/10343 (2013.01 - EP US); C12N 2710/10345 (2013.01 - EP US); C12N 2710/10351 (2013.01 - EP US); C12N 2800/30 (2013.01 - EP US); C12N 2810/405 (2013.01 - EP US); C12N 2810/6018 (2013.01 - EP US)

Citation (search report)

  • [XY] WO 0003029 A2 20000120 - INTROGENE BV [NL]
  • [XY] WO 0070071 A1 20001123 - INTROGENE BV [NL], et al
  • [XY] WO 0073478 A2 20001207 - UNIV WASHINGTON [US], et al
  • [XY] SHAYAKHMETOV D M ET AL: "EFFICIENT GENE TRANSFER INTO HUMAN CD34+ CELLS BY A RETARGETED ADENOVIRUS VECTOR", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 6, March 2000 (2000-03-01), pages 2567 - 2583, XP000938716, ISSN: 0022-538X
  • [Y] EINFELD D A ET AL: "Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 75, no. 23, December 2001 (2001-12-01), pages 11284 - 1291, XP002264247, ISSN: 0022-538X
  • [A] DECHECCHI M C ET AL: "Heparan Sulfate Glycosaminoglycans Are Involved in Adenovirus Type 5 and 2-Host Cell Interactions", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 268, no. 2, 15 March 2000 (2000-03-15), pages 382 - 390, XP004436082, ISSN: 0042-6822
  • [A] MAGNUSSON M K ET AL: "GENETIC RETARGETING OF ADENOVIRUS: NOVEL STRATEGY EMPLOYING DEKNOBBING OF THE FIBER", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 75, no. 16, August 2001 (2001-08-01), pages 7280 - 7289, XP001056142, ISSN: 0022-538X
  • [T] SMITH T A G ET AL: "Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice", HUMAN GENE THERAPY 20 MAY 2003 UNITED STATES, vol. 14, no. 8, 20 May 2003 (2003-05-20), pages 777 - 787, XP002427429, ISSN: 1043-0342
  • See references of WO 03062400A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR

DOCDB simple family (publication)

WO 03062400 A2 20030731; WO 03062400 A3 20050127; WO 03062400 A9 20050609; AU 2003210661 A1 20030902; CA 2474763 A1 20030731; EP 1516055 A2 20050323; EP 1516055 A4 20070808; JP 2006500902 A 20060112; JP 2009034109 A 20090219; JP 4488290 B2 20100623; US 2003215948 A1 20031120; US 2004002060 A1 20040101

DOCDB simple family (application)

US 0302295 W 20030124; AU 2003210661 A 20030124; CA 2474763 A 20030124; EP 03732097 A 20030124; JP 2003562268 A 20030124; JP 2008230453 A 20080909; US 35189003 A 20030124; US 40333703 A 20030327