EP 0656003 A1 19950607 - CONDENSED INDOLE DERIVATIVES AS 5HT 2C? AND 5HT 2B? ANTAGONISTS.
Title (en)
CONDENSED INDOLE DERIVATIVES AS 5HT 2C? AND 5HT 2B? ANTAGONISTS.
Title (de)
KONDENSIERTES INDOL DERIVATE ALS 5HT2C UND 5HT2B ANTAGONISTE.
Title (fr)
DERIVES D'INDOLE CONDENSES UTILISES COMME ANTAGONISTES DES RECEPTEURS 5HT 2C? et 5HT 2B?.
Publication
Application
Priority
- EP 9302031 W 19930729
- GB 9217674 A 19920820
- GB 9306461 A 19930329
Abstract (en)
[origin: WO9404533A1] Compounds of formula (I) or a salt thereof wherein: P represents a quinoline or isoquinoline residue, or a 5- or 6-membered aromatic heterocyclic ring containing up to three heteroatoms selected from nitrogen, oxygen or sulphur; R1 is hydrogen or C1-6 alkyl; R2, R3, R10 and R11 are independently hydrogen or C1-6 alkyl, or R10 and R11 together form a bond, or R2 and R10 or R3 and R11 together form a C2-6 alkylene chain; R4 is hydrogen, C1-6 alkyl, halogen, NR8R9 or OR12, where R8, R9 and R12 are independently hydrogen or C1-6 alkyl; R5 is hydrogen or C1-6 alkyl; R7 is hydrogen, C1-6 alkyl, OR12 or halogen, where R12 is hydrogen or C1-6 alkyl; n is 2 or 3; and the groups R13 and R14 are independently hydrogen or C1-6 alkyl, are 5HT2C/5HT2B receptor antagonists and are of potential use in the treatment of CNS disorders such as anxiety.
IPC 1-7
IPC 8 full level
A61K 31/435 (2006.01); A61P 43/00 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01)
IPC 8 main group level
C07D 209/00 (2006.01); C07D 213/00 (2006.01); C07D 401/00 (2006.01)
CPC (source: EP)
A61P 43/00 (2017.12); C07D 471/04 (2013.01); C07D 487/04 (2013.01)
Citation (search report)
See references of WO 9404533A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL
DOCDB simple family (publication)
WO 9404533 A1 19940303; AP 9300560 A0 19950219; AU 4704693 A 19940315; CA 2142721 A1 19940303; CN 1086819 A 19940518; EP 0656003 A1 19950607; IL 106737 A0 19940530; JP H08500580 A 19960123; MA 22955 A1 19940401; MX 9305037 A 19940331; NZ 254785 A 19950926; SI 9300438 A 19940331; TW 248557 B 19950601
DOCDB simple family (application)
EP 9302031 W 19930729; AP 9300560 A 19930819; AU 4704693 A 19930729; CA 2142721 A 19930729; CN 93116553 A 19930819; EP 93917699 A 19930729; IL 10673793 A 19930819; JP 50582894 A 19930729; MA 23262 A 19930818; MX 9305037 A 19930818; NZ 25478593 A 19930729; SI 9300438 A 19930820; TW 82106679 A 19930819