LCP1

LCP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D85
Dynodwyr
Cyfenwau	LCP1, CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, lymphocyte cytosolic protein 1
Dynodwyr allanol	OMIM: 153430 HomoloGene: 80174 GeneCards: LCP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • metal ion binding • actin filament binding • identical protein binding • GTPase binding • actin binding • integrin binding Cydrannau o'r gell • cytoplasm • cytosol • cell projection • bilen • focal adhesion • filopodium • ruffle • Cellbilen • stress fiber • ruffle membrane • Microffilament • actin cytoskeleton • actin filament bundle • podosome • phagocytic cup • extracellular exosome • Cytosgerbwd • extracellular space • cell junction • perinuclear region of cytoplasm Prosesau biolegol • extracellular matrix disassembly • positive regulation of podosome assembly • actin filament bundle assembly • regulation of intracellular protein transport • animal organ regeneration • protein kinase A signaling • cell migration • wound healing, spreading of cells • T cell activation involved in immune response • actin filament network formation • actin crosslink formation • interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3936	n/a
Ensembl	ENSG00000136167	n/a
UniProt	P13796	n/a
RefSeq (mRNA)	NM_002298	n/a
RefSeq (protein)	NP_002289 NP_002289.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LCP1 yw LCP1 a elwir hefyd yn Lymphocyte cytosolic protein 1 (L-plastin), isoform CRA_a a Lymphocyte cytosolic protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q14.13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LCP1.

• "L-plastin regulates the stability of the immune synapse of naive and effector T-cells. ". Adv Biol Regul. 2017. PMID 27720134.
• "L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions. ". Free Radic Biol Med. 2015. PMID 25881549.
• "Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation. ". Mol Cancer. 2014. PMID 24438191.
• "L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes. ". J Immunol. 2012. PMID 22581862.
• "L-plastin phosphorylation: a novel target for the immunosuppressive drug dexamethasone in primary human T cells.". Eur J Immunol. 2011. PMID 21805466.