ITGAM

ITGAM
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BHO, 1BHQ, 1IDN, 1IDO, 1JLM, 1M1U, 1MF7, 1N9Z, 1NA5, 2LKE, 2LKJ, 3Q3G, 3QA3, 4M76, 4XW2
Dynodwyr
Cyfenwau	ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin subunit alpha M
Dynodwyr allanol	OMIM: 120980 HomoloGene: 526 GeneCards: ITGAM
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • heat shock protein binding • amyloid-beta binding • complement component C3b binding • cargo receptor activity Cydrannau o'r gell • extracellular exosome • Cellbilen • cell surface • bilen • integral component of membrane • integrin complex • extracellular space • specific granule membrane • tertiary granule membrane • external side of plasma membrane • integrin alphaM-beta2 complex • plasma membrane raft • membrane raft Prosesau biolegol • ectodermal cell differentiation • toll-like receptor 4 signaling pathway • integrin-mediated signaling pathway • leukocyte migration • extracellular matrix organization • cell adhesion • neutrophil degranulation • microglial cell activation • immune system process • receptor-mediated endocytosis • phagocytosis, engulfment • cytokine-mediated signaling pathway • positive regulation of superoxide anion generation • positive regulation of neutrophil degranulation • innate immune response • negative regulation of dopamine metabolic process • positive regulation of protein targeting to membrane • amyloid-beta clearance • cell-cell adhesion via plasma-membrane adhesion molecules • complement-mediated synapse pruning • vertebrate eye-specific patterning • positive regulation of neuron death • positive regulation of microglial cell activation • positive regulation of microglial cell mediated cytotoxicity • cell surface receptor signaling pathway involved in cell-cell signaling • positive regulation of prostaglandin-E synthase activity • forebrain development • apoptotic signaling pathway • positive regulation of hippocampal neuron apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3684	n/a
Ensembl	ENSG00000169896	n/a
UniProt	P11215	n/a
RefSeq (mRNA)	NM_000632 NM_001145808	n/a
RefSeq (protein)	NP_000623 NP_001139280	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITGAM yw ITGAM a elwir hefyd yn Integrin alpha-M ac Integrin subunit alpha M (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p11.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITGAM.

• "The pathogenic relevance of αM-integrin in Guillain-Barré syndrome. ". Acta Neuropathol. 2016. PMID 27460017.
• "Atrial fibrillation is associated with high levels of monocyte-platelet-aggregates and increased CD11b expression in patients with aortic stenosis. ". Thromb Haemost. 2016. PMID 26763077.
• "Monocyte-platelet aggregates and CD11b expression as markers for thrombogenicity in atrial fibrillation. ". Clin Res Cardiol. 2016. PMID 26411420.
• "Prognostic Value of CD11b Expression Level for Acute Myeloid Leukemia Patients: A Meta-Analysis. ". PLoS One. 2015. PMID 26309131.
• "The opioid peptide dynorphin A induces leukocyte responses via integrin Mac-1 (αMβ2, CD11b/CD18).". Mol Pain. 2015. PMID 26036990.