BCL2L11

BCL2L11
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1F95, 2K7W, 2NL9, 2V6Q, 2VM6, 2WH6, 2YQ6, 2YQ7, 3D7V, 3FDL, 3IO8, 3IO9, 3KJ0, 3KJ1, 3KJ2, 4A1U, 4A1W, 4B4S, 4D2M, 4QVF, 4UF3, 4YJ4, 4ZIF, 4ZIH, 5AGW, 5AGX, 5C3G
Dynodwyr
Cyfenwau	BCL2L11, BAM, BIM, BOD, BCL2 like 11
Dynodwyr allanol	OMIM: 603827 HomoloGene: 7643 GeneCards: BCL2L11
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • microtubule binding • dynein complex binding • protein heterodimerization activity • protein kinase binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • intracellular membrane-bounded organelle • BIM-BCL-2 complex • mitochondrial outer membrane • BIM-BCL-xl complex • cytoplasmic dynein complex • mitocondria • microtubule • endomembrane system • extrinsic component of membrane • Bcl-2 family protein complex Prosesau biolegol • leukocyte homeostasis • regulation of apoptotic process • positive regulation of protein homooligomerization • male gonad development • positive regulation of cell death • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • B cell apoptotic process • kidney development • thymus development • lymphocyte homeostasis • positive regulation of apoptotic process by virus • myeloid cell homeostasis • post-embryonic animal organ morphogenesis • ear development • in utero embryonic development • B cell homeostasis • spleen development • thymocyte apoptotic process • post-embryonic development • response to endoplasmic reticulum stress • mammary gland development • T cell homeostasis • odontogenesis of dentin-containing tooth • positive regulation of IRE1-mediated unfolded protein response • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • tube formation • brain development • positive regulation of neuron apoptotic process • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of cell cycle • positive regulation of mitochondrial membrane permeability involved in apoptotic process • meiosis I • spermatogenesis • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of apoptotic process • positive regulation of fibroblast apoptotic process • developmental pigmentation • positive regulation of release of cytochrome c from mitochondria • regulation of developmental pigmentation • cell-matrix adhesion • regulation of organ growth • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of intrinsic apoptotic signaling pathway • apoptotic process involved in embryonic digit morphogenesis • GO:0097285 apoptotic process • protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of autophagy in response to ER overload • cellular response to glucocorticoid stimulus • cellular response to estradiol stimulus • cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10018	n/a
Ensembl	ENSG00000153094	n/a
UniProt	O43521	n/a
RefSeq (mRNA)	NM_001204106 NM_001204107 NM_001204108 NM_001204109 NM_001204110 NM_001204111 NM_001204112 NM_001204113 NM_006538 NM_138621 NM_138622 NM_138623 NM_138624 NM_138625 NM_138626 NM_138627 NM_207002 NM_207003	n/a
RefSeq (protein)	NP_001191035 NP_001191036 NP_001191037 NP_001191038 NP_001191039 NP_001191040 NP_001191041 NP_001191042 NP_006529 NP_619527 NP_619528 NP_619529 NP_619530 NP_619531 NP_619532 NP_619533 NP_996885 NP_996886	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BCL2L11 yw BCL2L11 a elwir hefyd yn Bcl-2-like protein 11 a BCL2 like 11 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BCL2L11.

• BAM
• BIM
• BOD

• "BIM deletion polymorphisms in Hispanic patients with non-small cell lung cancer carriers of EGFR mutations. ". Oncotarget. 2016. PMID 27926478.
• "CD4+ T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down-regulation of proapoptotic Bim in peripheral blood. ". J Leukoc Biol. 2017. PMID 27630216.
• "Bcl-2-like Protein 11 (BIM) Expression Is Associated with Favorable Prognosis for Patients with Cervical Cancer. ". Anticancer Res. 2017. PMID 28870908.
• "Lack of association between deletion polymorphism of BIM gene and in vitro drug sensitivity in B-cell precursor acute lymphoblastic leukemia. ". Leuk Res. 2017. PMID 28641145.
• "Clinical features of Bim deletion polymorphism and its relation with crizotinib primary resistance in Chinese patients with ALK/ROS1 fusion-positive non-small cell lung cancer.". Cancer. 2017. PMID 28346673.