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François Ferron

61
Documents
Affiliations actuelles
  • 550210
  • 1002356
Identifiants chercheurs

Domaines de recherche


Publications

Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

 Ashleigh Shannon , Véronique Fattorini , Bhawna Sama , Barbara Selisko , Mikael Feracci
2023
Pré-publication, Document de travail hal-04061889v1
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A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases

 Sergio Hernández , Mikael Feracci , Carolina Trajano de Jesus , Priscila El-Kazzi , Rafik Kaci
2022
Pré-publication, Document de travail hal-03660938v1
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Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication

 Natacha S Ogando , Priscila El Kazzi , Clara C Posthuma , Volker Thiel , Bruno Canard
2021
Pré-publication, Document de travail hal-03426119v1
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Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

 Ashleigh Shannon , Véronique Fattorini , Bhawna Sama , Barbara Selisko , Mikael Feracci
2021
Pré-publication, Document de travail hal-03367971v1
Image document

A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases

 Sergio Hernández , Mikael Feracci , Carolina Trajano de Jesus , Priscila El-Kazzi , Rafik Kaci
2021
Pré-publication, Document de travail hal-03411674v1
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Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

 Daniel L Hurdiss , Priscila El Kazzi , Lisa Bauer , Nicolas Papageorgiou , Francois Ferron
2021
Pré-publication, Document de travail hal-03411664v1

Arenaviridae exoribonuclease presents genomic RNA edition capacity.

 Elsie Laban Yekwa , Chutima Aphibanthammakit , Xavier Carnec , Caroline Picard , Bruno Canard
2019
Pré-publication, Document de travail hal-02361017v1
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Structural flexibility of Toscana virus nucleoprotein in the presence of a single-chain camelid antibody

 Nicolas Papageorgiou , Amal Baklouti , Julie Lichière , Aline Desmyter , Bruno Canard
Acta crystallographica Section D : Structural biology [1993-..], 2024, 80 (2), ⟨10.1107/S2059798324000196⟩
Article dans une revue hal-04416977v1
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Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options

 Mikael Feracci , Sergio Hernandez , Laura Garlatti , Clemence Mondielli , Renaud Vincentelli
International Union of Crystallography journal, 2024, 11 (3), pp.374-383. ⟨10.1107/S205225252400304X⟩
Article dans une revue hal-04746756v1
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The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution

 Aurelie Chazot , Claire Zimberger , Mikael Feracci , Adel Moussa , Steven Good
PLoS Biology, 2024, ⟨10.1101/2024.02.16.580631⟩
Article dans une revue hal-04474786v1
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AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5

 Mikael Feracci , Cécilia Eydoux , Véronique Fattorini , Lea Lo Bello , Pierre Gauffre
Antiviral Research, 2023, 212, pp.105574. ⟨10.1016/j.antiviral.2023.105574⟩
Article dans une revue hal-04159074v1
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Biochemistry of the Respiratory Syncytial Virus L Protein Embedding RNA Polymerase and Capping Activities

 Priscila Sutto-Ortiz , Jean-François Eléouët , François Ferron , Etienne Decroly
Viruses, 2023, 15 (2), pp.341. ⟨10.3390/v15020341⟩
Article dans une revue hal-03981809v1
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Viral Instant Mutation Viewer (VIMVer) : a tool to speed up the identification and analysis of new SARS-CoV2 emerging variant and beyond

 Vincent Wilde , Bruno Canard , François Ferron
Viruses, 2023, 15 (8), pp.1628. ⟨10.3390/v15081628⟩
Article dans une revue hal-04149011v1
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Macro1 domain residue F156: A hallmark of SARS-CoV-2 de-MARylation specificity

 Oney Ortega Granda , Karine Alvarez , Maria J Mate-Perez , Bruno Canard , François Ferron
Virology, 2023, 587, pp.109845. ⟨10.1016/j.virol.2023.109845⟩
Article dans une revue hal-04199059v1
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Arenaviridae NP-exonuclease inhibition by bisphosphonate

 Thi Hong van Nguyen , Elsie Yekwa , Barbara Selisko , Bruno Canard , Karine Alvarez
International Union of Crystallography journal, 2022, 9 (4), ⟨10.1107/S2052252522005061⟩
Article dans une revue hal-03663359v1
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A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome

 Ashleigh Shannon , Bhawna Sama , Pierre Gauffre , Théo Guez , Françoise Debart
Nucleic Acids Research, 2022, 50 (19), pp.11186-11198. ⟨10.1093/nar/gkac876⟩
Article dans une revue hal-03937366v1
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A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

 Ashleigh Shannon , Véronique Fattorini , Bhawna Sama , Barbara Selisko , Mikael Feracci
Nature Communications, 2022, 13, ⟨10.1038/s41467-022-28113-1⟩
Article dans une revue hal-03572811v1
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Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect

 Priscila El Kazzi , Nadia Rabah , Célia Chamontin , Lina Poulain , François Ferron
Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac996⟩
Article dans une revue hal-03860650v1
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Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay

 Sergio Hernández , Mikael Feracci , Carolina Trajano de Jesus , Priscila El Kazzi , Rafik Kaci
Antiviral Research, 2022, 204, pp.105364. ⟨10.1016/j.antiviral.2022.105364⟩
Article dans une revue hal-03860671v1
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Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

 Daniel L Hurdiss , Priscila El Kazzi , Lisa Bauer , Nicolas Papageorgiou , Francois Ferron
Science Advances , 2022, 8 (1), ⟨10.1126/sciadv.abj7615⟩
Article dans une revue hal-03572836v1
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Observation of arenavirus nucleoprotein heptamer assembly

 Nicolas Papageorgiou , Afroditi Vaitsopoulou , Awa Diop , Thi Hong van Nguyen , Bruno Canard
FEBS Open Bio, 2021, ⟨10.1002/2211-5463.13106⟩
Article dans une revue hal-03143071v1
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First insights into the structural features of Ebola virus methyltransferase activities

 Coralie Valle , Baptiste Martin , François Ferron , Véronique Roig-Zamboni , Aline Desmyter
Nucleic Acids Research, 2021, 49 (3), pp.1737 - 1748. ⟨10.1093/nar/gkaa1276⟩
Article dans une revue hal-03334409v1
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The enzymes for genome size increase and maintenance of large (+)RNA viruses

 Francois Ferron , Bhawna Sama , Etienne Decroly , Bruno Canard
Trends in Biochemical Sciences, 2021, ⟨10.1016/j.tibs.2021.05.006⟩
Article dans une revue hal-03345450v1
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Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication

 Natacha S Ogando , Priscila El Kazzi , Jessika C Zevenhoven-Dobbe , Brenda W Bontes , Alice Decombe
Proceedings of the National Academy of Sciences of the United States of America, 2021, ⟨10.1101/2021.05.17.444407⟩
Article dans une revue hal-03411659v1
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Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

 Ashleigh Shannon , Barbara Selisko , Nhung-Thi-Tuyet Le , Johanna Huchting , Franck Touret
Nature Communications, 2020, 11 (1), pp.4682. ⟨10.1038/s41467-020-18463-z⟩
Article dans une revue inserm-03052188v1
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Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

 Ashleigh Shannon , Nhung Thi-Tuyet Le , Barbara Selisko , Cecilia Eydoux , Karine Alvarez
Antiviral Research, 2020, 178, pp.104793. ⟨10.1016/j.antiviral.2020.104793⟩
Article dans une revue hal-03052253v1
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Brothers in Arms: Structure, Assembly and Function of Arenaviridae Nucleoprotein

 Nicolas Papageorgiou , Maria Spiliopoulou , Thi-Hong van Nguyen , Afroditi Vaitsopoulou , Elsie Yekwa Laban
Viruses, 2020, 12 (7), pp.772. ⟨10.3390/v12070772⟩
Article dans une revue hal-03052241v1
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A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae

 Francois Ferron , Humberto Julio Debat , Ashleigh Shannon , Etienne Decroly , Bruno Canard
NAR Genomics and Bioinformatics, 2020, 2 (1), ⟨10.1093/nargab/lqz022⟩
Article dans une revue hal-02890583v1

Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain

 Magali Saez-Ayala , Elsie Laban Yekwa , Clémence Mondielli , Loic Roux , Sergio Hernández
Antiviral Research, 2019, 162, pp.79-89. ⟨10.1016/j.antiviral.2018.12.008⟩
Article dans une revue hal-03076409v1
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The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

 Natacha S Ogando , Francois Ferron , Etienne Decroly , Bruno Canard , Clara C Posthuma
Frontiers in Microbiology, 2019, 10, ⟨10.3389/fmicb.2019.01813⟩
Article dans une revue hal-02353805v1
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Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein

 Thi Hong Van Nguyen , Julie Lichiere , Bruno Canard , Nicolas Papageorgiou , Sarah Attoumani
Acta crystallographica Section D : Structural biology [1993-..], 2019, 75 (1), pp.8-15. ⟨10.1107/S2059798318014948⟩
Article dans une revue inserm-02416977v1
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Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands

 Magali Saez-Ayala , Elsie Yekwa , Mauro Carcelli , Bruno Canard , Karine Alvarez
International Union of Crystallography journal, 2018, 5 (1), pp.223 - 235. ⟨10.1107/s2052252518001021⟩
Article dans une revue hal-03078366v1
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Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

 Barbara Selisko , Nicolas Papageorgiou , Francois Ferron , Bruno Canard
Viruses, 2018, 10 (2), pp.59. ⟨10.3390/v10020059⟩
Article dans une revue hal-02094550v1
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Crystal structures of Lymphocytic choriomeningitis virus endonuclease domain complexed with diketo-acid ligands

 Magali Saez-Ayala , Elsie Laban Yekwa , Mauro Carcelli , Bruno Canard , Karine Alvarez
International Union of Crystallography journal, 2018, 5 (2), pp.223-235. ⟨10.1107/S2052252518001021⟩
Article dans une revue hal-02094538v1

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

 Francois Ferron , Lorenzo Subissi , Ana Theresa Silveira de Morais , Nhung Thi Tuyet Le , Marion Sevajol
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (2), pp.E162-E171. ⟨10.1073/pnas.1718806115⟩
Article dans une revue hal-02094607v1

A Vaccine Platform against Arenaviruses Based on a Recombinant Hyperattenuated Mopeia Virus Expressing Heterologous Glycoproteins

 Xavier Carnec , Mathieu Mateo , Audrey Page , Stéphanie Reynard , Jimmy Hortion
Journal of Virology, 2018, 92 (12), pp.e02230-17. ⟨10.1128/JVI.02230-17⟩
Article dans une revue hal-02329298v1

Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2′-modified nucleotide analogues

 Supanee Potisopon , Francois Ferron , Véronique Fattorini , Barbara Selisko , Bruno Canard
Antiviral Research, 2017, 140, pp.25 - 36. ⟨10.1016/j.antiviral.2016.12.021⟩
Article dans une revue hal-01802946v1
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Activity inhibition and crystal polymorphism induced by active-site metal swapping

 Elsie Yekwa , Joelle Khourieh , Bruno Canard , Nicolas Papageorgiou , Francois Ferron
Acta crystallographica Section D : Structural biology [1993-..], 2017, 73 (8), pp.641-649. ⟨10.1107/S205979831700866X⟩
Article dans une revue hal-03078421v1

Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins

 Francois Ferron , Friedemann Weber , Juan de La Torre , Juan Reguera
Virus Research, 2017, 234, pp.118 - 134. ⟨10.1016/j.virusres.2017.01.018⟩
Article dans une revue hal-01802833v1

Toscana virus nucleoprotein oligomer organization observed in solution

 Amal Baklouti , Adeline Goulet , Julie Lichiere , Bruno Canard , Remi Charrel
Acta crystallographica Section D : Structural biology [1993-..], 2017, 73 (8), pp.650 - 659. ⟨10.1107/S2059798317008774⟩
Article dans une revue hal-01802854v1
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How disordered is my protein and what is its disorder for? A guide through the “dark side” of the protein universe

 Philippe Lieutaud , François Ferron , Alexey V Uversky , Lukasz Kurgan , Vladimir N Uversky
Intrinsically Disordered Proteins, 2016, 4 (1), pp.e1259708. ⟨10.1080/21690707.2016.1259708⟩
Article dans une revue hal-03499972v1

Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering

 Nicolas Papageorgiou , Julie Lichiere , Amal Baklouti , Francois Ferron , Marion Sevajol
Acta crystallographica Section D : Structural biology [1993-..], 2016, 72 (2), pp.192-202. ⟨10.1107/S2059798315024328⟩
Article dans une revue hal-01439080v1

Enzymatic synthesis of acyclic nucleoside thiophosphonate diphosphates: Effect of the alpha-phosphorus configuration on HIV-1 RT activity

 Stephane Priet , Loic Roux , Magali Saez-Ayala , Francois Ferron , Bruno Canard
Antiviral Research, 2015, 117, pp.122-131. ⟨10.1016/j.antiviral.2015.03.003⟩
Article dans une revue hal-01439000v1

Crystallization and diffraction analysis of the SARS coronavirus nsp10-nsp16 complex.

 Claire Debarnot , Isabelle Imbert , Francois Ferron , Laure Gluais , Isabelle Varlet
Acta crystallographica Section F : Structural biology communications [2014-..], 2011, 67 (Pt 3), pp.404-8. ⟨10.1107/S1744309111002867⟩
Article dans une revue hal-00751530v1

VaZyMolO: a tool to define and classify modularity in viral proteins

 François Ferron , Corinne Rancurel , Sonia Longhi , Christian Cambillau , Bernard Henrissat
Journal of General Virology, 2005, 86 (3), pp.743-749. ⟨10.1099/vir.0.80590-0⟩
Article dans une revue hal-04080540v1
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The modeled structure of the RNA dependent RNA polymerase of GBV-C virus suggests a role for motif E in Flaviviridae RNA polymerases.

 Francois Ferron , Cécile Bussetta , Hélène Dutartre , Bruno Canard
BMC Bioinformatics, 2005, 6 (1), pp.255. ⟨10.1186/1471-2105-6-255⟩
Article dans une revue hal-02459250v1

The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world

 Marie-Pierre Egloff , Francois Ferron , Valérie Campanacci , Sonia Longhi , Corinne Rancurel
Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (11), pp.3792-3796. ⟨10.1073/pnas.0307877101⟩
Article dans une revue hal-02459257v1

Structural genomics of the SARS coronavirus: cloning, expression, crystallization and preliminary crystallographic study of the Nsp9 protein

 Valérie Campanacci , Marie-Pierre Egloff , Sonia Longhi , François Ferron , Corinne Rancurel
Acta Crystallographica Section D: Biological Crystallography, 2003, 59 (9), pp.1628-1631. ⟨10.1107/S0907444903016779⟩
Article dans une revue hal-04080543v1
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How did you annotate your new viral genome without it ? VAZyMolO-2

 Vincent Wilde , Bruno Canard , Francois Ferron
ViBioM2024, May 2024, Luven, Belgium
Poster de conférence hal-04616074v1
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Structural characterisation and inhibition of Arenavirus replication complex elements : assembly, function and inhibition of embedded nucleases

 Sergio Hernández , Nicolas Papageorgiou , Maria Spiliopoulou , Mikael Feracci , Laura Garlatti
26TH CONGRESS AND GENERAL ASSEMBLY OF THE INTERNATIONAL UNION OF CRYSTALLOGRAPHY, Aug 2023, Melbourne (AUS), Australia
Poster de conférence hal-04180334v1
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Le complexe nsp14:nsp10 du SARS-CoV-2 stabilisé par un nanobody

 Pierre Gauffre , Anaïs Gaubert , Maria Mate-Perez , Bruno Canard , François Ferron
XXVèmes Journées Francophones de Virologie, Apr 2023, Paris, France. Virologie, 27 (2), pp.48-49, 2023, ⟨10.1684/vir.2023.993⟩
Poster de conférence hal-04246262v1
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Viral Instant Mutation Viewer (VIMVer): a tool to speed up the identification and analysis of new SARS-CoV2 emerging variant

 Vincent Wilde , Bruno Canard , Francois Ferron
ViBioM 2022, Mar 2022, Valencia, Spain. online
Poster de conférence hal-04387599v1
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Analyse structurale de la nouvelle N7 guanine-MTase du virus de la Brème bordelière

 Pierre Gauffre , Ashleigh Shannon , Bhawna Sama , Bruno Canard , François Ferron
23ème Journées Francophones de Virologie, Apr 2021, Paris (en ligne), France. Virologie. 2021;25(1):68-74, 25 (S1), pp.68-74, 2021, ⟨10.1684/vir.2021.0892⟩
Poster de conférence hal-04246230v1

The Phlebovirus Ribonucleoprotein: An Overview

 François Ferron , Julien Lescar
Rift Valley Fever Virus, 2824, Springer US, pp.259-280, 2024, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3926-9_17⟩
Chapitre d'ouvrage hal-04746919v1

Predicting Conformational Disorder

 Philippe Lieutaud , François Ferron , Sonia Longhi
Data Mining Techniques for the Life Sciences, 1415, Springer New York, pp.265-299, 2016, Methods in Molecular Biology, ⟨10.1007/978-1-4939-3572-7_14⟩
Chapitre d'ouvrage hal-03499961v1
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Identification of a Nidovirales Orf1a N7-guanine cap Methyltransferase signature- sequence as a genetic marker of large genome Tobaniviridae Running title: RNA cap N7-guanine Methyltransferase in Tobaniviridae Orf1a

 Francois Ferron , Humberto Julio Debat , Etienne Decroly , Bruno Canard
2019, ⟨10.1101/639369⟩
Autre publication scientifique hal-02354224v1
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Etudes structurales des assemblages macromoléculaires : Du cytosquelette d'actine aux virus à ARN

 Francois Ferron
Sciences du Vivant [q-bio]. Aix-Marseille Université, 2015
HDR tel-02329070v1
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Cellular activation pathway of bemnifosbuvir (AT-527), a drug candidate against SARS-CoV-2 infections

 A. Chazot , C. Zimberger , M. Feracci , S. Hernandez , C. Falcou
XXVI IUCr Congress Melbourne, Australia, 22-29 August 2023, Aug 2023, MELBOURNE, Australia. pp.C1042-C1042, ⟨10.1107/S2053273323085790⟩
Communication dans un congrès hal-04748663v1
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Structural characterisation and inhibition of arenavirus replication complex elements: assembly, function and inhibition of embedded nucleases

 S. Hernandez , N. Papageorgiou , M. Spiliopoulou , M. Ferracci , L. Garlatti
XXVI IUCr Congress Melbourne, Australia, 22-29 August 2023, Aug 2023, MELBOURNE, Australia. pp.C677-C677, ⟨10.1107/S2053273323089404⟩
Communication dans un congrès hal-04748656v1
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A highly specific N7-guanine RNA cap methyltransferase in an unusual locus of large RNA virus genome

 A. Shannon , B. Sama , P. Gauffre , B. Makem-Tamekem , E. Decroly
Acta Crystallographica Section A : Foundations and Advances [2014-..], 78 (a2), pp.e324-e324, 2022, ⟨10.1107/S2053273322094049⟩
Proceedings/Recueil des communications hal-04252756v1
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Approches bioinformatiques et structurales des replicases virales

 Francois Ferron
Autre [q-bio.OT]. Université de la Méditerranée - Aix-Marseille II, 2005. Français. ⟨NNT : ⟩
Thèse tel-00010419v2