Abstract: Probabilistic interval-valued intuitionistic hesitant fuzzy sets (PIVIHFSs) can well describe the evaluation information of decision-makers (DMs) in multi-attribute decision-making (MADM) problems. However, PIVIHFSs only depict the situation where both membership and non-membership information occur with equal probability while ignoring the situations of non-equal possibility due to DMs’ subjective preferences. In this paper, we develop dual probabilistic interval-valued intuitionistic hesitant fuzzy sets (DPIVIHFSs) concept based on the truncated normal distribution. The DPIVIHFSs overcome the shortcomings of PIVIHFSs and are more interpretable. Then, the operations and ranking method of DPIVIHFSs are introduced. Furthermore, we study MADM methods in dual probabilistic interval-valued intuitionistic…hesitant fuzzy environments by aggregation operators (AOs). We propose a series of AOs including the DPIVIHF heronian mean (DPIVIHFHM) operator and the DPIVIHF weighted heronian mean (DPIVIHFWHM) operator. The basic properties of the presented are discussed and proved. Finally, a novel method for solving the MADM problem is proposed based on the DPIVIHFWHM operator and a numerical example of express company selection strategy is used to illustrate the effectiveness of the method. The proposed method in this article can capture more fuzzy and uncertain information when solving MADM problems and have a wider application range.
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Keywords: Multi-attribute decision-making, DPIVIHFS, truncated normal distribution, DPIVIHFWHM, express company selection strategy
Abstract: Anesthesia and/or surgery may promote Alzheimer’s disease (AD) by accelerating its neuropathogenesis. Other studies showed different findings. However, the potential sex difference among these studies has not been well considered, and it is unknown whether male or female AD patients are more vulnerable to develop postoperative cognitive dysfunction. We therefore set out to perform a proof of concept study to determine whether anesthesia and surgery can have different effects in male and female AD transgenic (Tg) mice, and in female AD Tg plus Cyclophilin D knockout (CypD KO) mice. The mice received an abdominal surgery under sevoflurane anesthesia (anesthesia/surgery). Fear…Conditioning System (FCS) was used to assess the cognitive function. Hippocampal levels of synaptic marker postsynaptic density 95 (PSD-95) and synaptophysin (SVP) were measured using western blot analysis. Here we showed that the anesthesia/surgery decreased the freezing time in context test of FCS at 7 days after the anesthesia/surgery in female, but not male, mice. The anesthesia/surgery reduced hippocampus levels of synaptic marker PSD-95 and SVP in female, but not male, mice. The anesthesia/surgery induced neither reduction in freezing time in FCS nor decreased hippocampus levels of PSD-95 and SVP in the AD Tg plus CypD KO mice. These data suggest that the anesthesia/surgery induced a sex-dependent cognitive impairment and reduction in hippocampus levels of synaptic markers in AD Tg mice, potentially via a mitochondria-associated mechanism. These findings could promote clinical investigations to determine whether female AD patients are more vulnerable to the development of postoperative cognitive dysfunction.
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