GAS5

GAS5
Identifikatori
Aliasi	GAS5
Vanjski ID-jevi	OMIM: 608280 GeneCards: GAS5
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	173,868,882 bp
Ortolozi
	60674
	n/a
	ENSG00000234741
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Protein 5 specifičnog zastoja rasta kontrolira dugolančana nekodirajuća RNK koja je kod ljudi kodirana genom GAS5 sa hromosoma 1.^[3]^[4]

GAS5 nekodirajuća RNK, koja se acumulira i ćelijama sa zastojem rasta djeluje na element hormonskog odgovora za glukokortikoidni receptor (GR) i tako blokira nadregulciju ekspresije gena aktiviranog GR.^[5]^[6]

Brojne studije povezuju GAS5 sa apoptozama i može imati ulogu u napredovanju nekih tipova raka.^[7]^[8]^[9]

GAS5 introni sadrže nekoliko snoRNK sekvenci, uključujući SNORD81, SNORD47, SNORD80, SNORD79, SNORD78, SNORD44, SNORD78, SNORD44, SNORD78, SNORD44, SNORD 7, SNORD76, SNORD75|SNORD75 i SNORD74.^[4]^[10]^[11]^[12] Ove intronske sekvence su konzerviranije od egzona gena domaćina, a ti tipovi gena često nazivaju se "geni iznutra prema van".^[13]

Nedavno je otkriveno da nonsens posredovana degradacija može regulirati funkciju GAS5 u čelijama sisara.^[14]

Sadržaj gena u genomu sisara je tema od velikog interesa. Dok su nacrt sekvence sada dostupne za genome čovjeka, miša (www.ensembl.org/Mus_musculus) i pacova (http://hgsc.bcm.tmc.edu/projects/rat Arhivirano 29. 12. 2008. na Wayback Machine), izazov ostaje da ispravno identifikuju sve kodirajuće gene. Poteškoće u dešifriranju strukture gena sisara nastaju zbog nekoliko faktora, uključujući velike količine intervenirajuće (nekodirajuće) sekvence, nesavršenost algoritama za predviđanje gena (3) i nepotpunost resursa sekvence cDNK, od kojih se mnogi sastoje od gena, promjenjive dužine i kvaliteta. Sekvence cDNK pune dužine su izuzetno korisne za određivanje genomske strukture gena, posebno kada se analiziraju u kontekstu genomske sekvence. Kako bi olakšali napore u identifikaciji gena i da bi katalizirali eksperimentalno istraživanje, Nacionalni institut za zdravlje (NIH) pokrenuo je program za prikupljanje gena sisara (MGC) (4) s ciljem pružanja slobodno dostupnih, visokokvalitetnih sekvenci za validiranu, kompletnu ORF cDNK klonovi. U ovom članku opisujemo naš napredak prema cilju identificiranja i preciznog sekvenciranja najmanje jednog potpunog klona cDNK koji sadrži ORF za svaki ljudski i mišji gen, kao i da se ovi potpuno sekvencionirani klonove učine dostupnim bez ograničenja.^[15]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000234741 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: growth arrest-specific 5 (non-protein coding)".
^ ^a ^b Smith, C. M.; Steitz, J. A. (decembar 1998). "Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes". Molecular and Cellular Biology. 18 (12): 6897–6909. doi:10.1128/mcb.18.12.6897. PMC 109273. PMID 9819378.
^ Kino T, Hurt DE, Ichijo T, Nader N, Chrousos GP (2010). "Noncoding RNA Gas5 Is a Growth Arrest and Starvation-Associated Repressor of the Glucocorticoid Receptor". Sci Signal. 3 (107): ra8. doi:10.1126/scisignal.2000568. PMC 2819218. PMID 20124551.
^ Garabedian MJ, Logan SK (2010). "Glucocorticoid receptor DNA binding decoy is a gas". Sci Signal. 3 (108): pe5. doi:10.1126/scisignal.3108pe5. PMID 20145207. S2CID 21089519.
^ Mourtada-Maarabouni M, Pickard MR, Hedge VL, Farzaneh F, Williams GT (2009). "GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer". Oncogene. 28 (2): 195–208. doi:10.1038/onc.2008.373. PMID 18836484.
^ Nakamura Y, Takahashi N, Kakegawa E, Yoshida K, Ito Y, Kayano H, Niitsu N, Jinnai I, Bessho M (2008). "The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma". Cancer Genet Cytogenet. 182 (2): 144–9. doi:10.1016/j.cancergencyto.2008.01.013. PMID 18406879.
^ Mourtada-Maarabouni M, Hedge VL, Kirkham L, Farzaneh F, Williams GT (2008). "Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5)". J Cell Sci. 121 (Pt 7): 939–46. doi:10.1242/jcs.024646. PMID 18354083.
^ Tanaka R, Satoh H, Moriyama M, Satoh K, Morishita Y, Yoshida S, Watanabe T, Nakamura Y, Mori S (2000). "Intronic U50 small-nucleolar-RNA (snoRNA) host gene of no protein-coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B-cell lymphoma". Genes Cells. 5 (4): 277–87. doi:10.1046/j.1365-2443.2000.00325.x. PMID 10792466.
^ Raho G, Barone V, Rossi D, Philipson L, Sorrentino V (2000). "The gas 5 gene shows four alternative splicing patterns without coding for a protein". Gene. 256 (1–2): 13–7. doi:10.1016/S0378-1119(00)00363-2. PMID 11054530.
^ Hirose T, Steitz JA (2001). "Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells". Proc. Natl. Acad. Sci. U.S.A. 98 (23): 12914–9. Bibcode:2001PNAS...9812914H. doi:10.1073/pnas.231490998. PMC 60799. PMID 11606788.
^ Eddy SR (1999). "Noncoding RNA genes". Current Opinion in Genetics & Development. 9 (6): 695–9. doi:10.1016/S0959-437X(99)00022-2. PMID 10607607.
^ Tani H, Torimura M, Akimitsu N (2013). "The RNA degradation pathway regulates the function of GAS5 a non-coding RNA in mammalian cells". PLOS ONE. 8 (1): e556884. Bibcode:2013PLoSO...855684T. doi:10.1371/journal.pone.0055684. PMC 3559549. PMID 23383264.
^ Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Dopunska literatura

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000234741 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: growth arrest-specific 5 (non-protein coding)".

[pmid9819378-4] Smith, C. M.; Steitz, J. A. (decembar 1998). "Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes". Molecular and Cellular Biology. 18 (12): 6897–6909. doi:10.1128/mcb.18.12.6897. PMC 109273. PMID 9819378.

[pmid20124551-5] Kino T, Hurt DE, Ichijo T, Nader N, Chrousos GP (2010). "Noncoding RNA Gas5 Is a Growth Arrest and Starvation-Associated Repressor of the Glucocorticoid Receptor". Sci Signal. 3 (107): ra8. doi:10.1126/scisignal.2000568. PMC 2819218. PMID 20124551.

[pmid20145207-6] Garabedian MJ, Logan SK (2010). "Glucocorticoid receptor DNA binding decoy is a gas". Sci Signal. 3 (108): pe5. doi:10.1126/scisignal.3108pe5. PMID 20145207. S2CID 21089519.

[pmid18836484-7] Mourtada-Maarabouni M, Pickard MR, Hedge VL, Farzaneh F, Williams GT (2009). "GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer". Oncogene. 28 (2): 195–208. doi:10.1038/onc.2008.373. PMID 18836484.

[pmid18406879-8] Nakamura Y, Takahashi N, Kakegawa E, Yoshida K, Ito Y, Kayano H, Niitsu N, Jinnai I, Bessho M (2008). "The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma". Cancer Genet Cytogenet. 182 (2): 144–9. doi:10.1016/j.cancergencyto.2008.01.013. PMID 18406879.

[pmid18354083-9] Mourtada-Maarabouni M, Hedge VL, Kirkham L, Farzaneh F, Williams GT (2008). "Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5)". J Cell Sci. 121 (Pt 7): 939–46. doi:10.1242/jcs.024646. PMID 18354083.

[pmid10792466-10] Tanaka R, Satoh H, Moriyama M, Satoh K, Morishita Y, Yoshida S, Watanabe T, Nakamura Y, Mori S (2000). "Intronic U50 small-nucleolar-RNA (snoRNA) host gene of no protein-coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B-cell lymphoma". Genes Cells. 5 (4): 277–87. doi:10.1046/j.1365-2443.2000.00325.x. PMID 10792466.

[pmid11054530-11] Raho G, Barone V, Rossi D, Philipson L, Sorrentino V (2000). "The gas 5 gene shows four alternative splicing patterns without coding for a protein". Gene. 256 (1–2): 13–7. doi:10.1016/S0378-1119(00)00363-2. PMID 11054530.

[pmid11606788-12] Hirose T, Steitz JA (2001). "Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells". Proc. Natl. Acad. Sci. U.S.A. 98 (23): 12914–9. Bibcode:2001PNAS...9812914H. doi:10.1073/pnas.231490998. PMC 60799. PMID 11606788.

[pmid10607607-13] Eddy SR (1999). "Noncoding RNA genes". Current Opinion in Genetics & Development. 9 (6): 695–9. doi:10.1016/S0959-437X(99)00022-2. PMID 10607607.

[pmid23383264-14] Tani H, Torimura M, Akimitsu N (2013). "The RNA degradation pathway regulates the function of GAS5 a non-coding RNA in mammalian cells". PLOS ONE. 8 (1): e556884. Bibcode:2013PLoSO...855684T. doi:10.1371/journal.pone.0055684. PMC 3559549. PMID 23383264.

[15] Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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