SYBU

SYBU
Identifikatori
Aliasi	SYBU
Vanjski ID-jevi	OMIM: 611568 MGI: 2442392 HomoloGene: 9838 GeneCards: SYBU
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	109,691,791 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	44,651,459 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• microtubule binding; • GO:0001948, GO:0016582 vezivanje za proteine; • syntaxin-1 binding; • kinesin binding;
Ćelijska komponenta	• citoplazma; • GO:0016023 citoplazmatska vezikula; • integral component of membrane; • Golđijeva membrana; • Golđijev aparat; • dense body; • intracellular membrane-bounded organelle; • citoskelet; • membrana; • Mikrotubula; • Vezikula; • axon cytoplasm;
Biološki proces	• regulation of insulin secretion involved in cellular response to glucose stimulus; • axonal transport of mitochondrion; • positive regulation of insulin secretion involved in cellular response to glucose stimulus; • regulation of synaptic activity; • synapse maturation; • anterograde neuronal dense core vesicle transport;
	Izvori:Amigo / QuickGO
Ortolozi
	55638
	319613
	ENSG00000147642
	ENSMUSG00000022340
	Q9NX95
	Q8BHS8
NM_001099743; NM_001099744; NM_001099745; NM_001099746; NM_001099747;
	NM_001099748; NM_001099749; NM_001099750; NM_001099751; NM_001099752; NM_001099753; NM_001099754; NM_001099755; NM_001099756; NM_017786; NM_001330596; NM_001363032
NM_001032727; NM_001285840; NM_001285841; NM_001285842; NM_001285843;
	NM_001285844; NM_176998; NM_178765; NM_001358582; NM_001358583; NM_001358584
NP_001093213; NP_001093214; NP_001093215; NP_001093216; NP_001093217;
	NP_001093218; NP_001093219; NP_001093220; NP_001093221; NP_001093222; NP_001093223; NP_001093224; NP_001093225; NP_001093226; NP_001317525; NP_060256; NP_001349961
NP_001027899; NP_001272769; NP_001272770; NP_001272771; NP_001272772;
	NP_001272773; NP_795972; NP_848880; NP_001345511; NP_001345512; NP_001345513
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Sintabulin, poznat i kao SYBU, je ljudki gen.^[5]

Aminokiselinska sekvenca

Dužina kontroliranog polipeptidnog lanca je 663 aminokiseline, а molekulska težina 72.388 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGPLRESKKE	HRVQHHDKEI	SRSRIPRLIL	RPHMPQQQHK	VSPASESPFS
EEESREFNPS	SSGRSARTVS	SNSFCSDDTG	CPSSQSVSPV	KTPSDAGNSP
IGFCPGSDEG	FTRKKCTIGM	VGEGSIQSSR	YKKESKSGLV	KPGSEADFSS
SSSTGSISAP	EVHMSTAGSK	RSSSSRNRGP	HGRSNGASSH	KPGSSPSSPR
EKDLLSMLCR	NQLSPVNIHP	SYAPSSPSSS	NSGSYKGSDC	SPIMRRSGRY
MSCGENHGVR	PPNPEQYLTP	LQQKEVTVRH	LKTKLKESER	RLHERESEIV
ELKSQLARMR	EDWIEEECHR	VEAQLALKEA	RKEIKQLKQV	IETMRSSLAD
KDKGIQKYFV	DINIQNKKLE	SLLQSMEMAH	SGSLRDELCL	DFPCDSPEKS
LTLNPPLDTM	ADGLSLEEQV	TGEGADRELL	VGDSIANSTD	LFDEIVTATT
TESGDLELVH	STPGANVLEL	LPIVMGQEEG	SVVVERAVQT	DVVPYSPAIS
ELIQSVLQKL	QDPCPSSLAS	PDESEPDSME	SFPESLSALV	VDLTPRNPNS
AILLSPVETP	YANVDAEVHA	NRLMRELDFA	ACVEERLDGV	IPLARGGVVR
QYWSSSFLVD	LLAVAAPVVP	TVLWAFSTQR	GGTDPVYNIG	ALLRGCCVVA
LHSLRRTAFR	IKT

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147642 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022340 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FLJ20366 hypothetical protein FLJ20366".
^ "UniProt, Q9NX95" (jezik: engleski). Pristupljeno 21. 9. 2021.

Dopunska literatura

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Su Q, Cai Q, Gerwin C, et al. (2004). "Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons". Nat. Cell Biol. 6 (10): 941–53. doi:10.1038/ncb1169. PMID 15459722. S2CID 6875457.
Funakoshi E, Nakagawa KY, Hamano A, et al. (2005). "Molecular cloning and characterization of gene for Golgi-localized syntaphilin-related protein on human chromosome 8q23". Gene. 344: 259–71. doi:10.1016/j.gene.2004.10.024. PMID 15656992.
Cai Q, Gerwin C, Sheng ZH (2005). "Syntabulin-mediated anterograde transport of mitochondria along neuronal processes". J. Cell Biol. 170 (6): 959–69. doi:10.1083/jcb.200506042. PMC 1804288. PMID 16157705.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Funakoshi E, Fukui M, Hamano A, et al. (2006). "Expression of m-Golsyn/Syntabulin gene during mouse brain development". Neurosci. Lett. 403 (3): 244–9. doi:10.1016/j.neulet.2006.04.061. PMID 16750881. S2CID 40236853.
Cai Q, Pan PY, Sheng ZH (2007). "Syntabulin-kinesin-1 family member 5B-mediated axonal transport contributes to activity-dependent presynaptic assembly". J. Neurosci. 27 (27): 7284–96. doi:10.1523/JNEUROSCI.0731-07.2007. PMC 6794594. PMID 17611281.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147642 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022340 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FLJ20366 hypothetical protein FLJ20366".

[UniProt-6] "UniProt, Q9NX95" (jezik: engleski). Pristupljeno 21. 9. 2021.

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