MFAP1

MFAP1
Identifikatori
Aliasi	MFAP1
Vanjski ID-jevi	OMIM: 600215 MGI: 1914782 HomoloGene: 4332 GeneCards: MFAP1
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	43,824,690 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	121,337,146 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK;
Ćelijska komponenta	• Mikrovlakno; • extracellular region; • jedro; • spliceosomal complex; • U2-type precatalytic spliceosome;
Biološki proces	• GO:0022610 biološki proces; • mRNA splicing, via spliceosome; • mRNA processing; • Prerada RNK;
	Izvori:Amigo / QuickGO
Ortolozi
	4236
	67532
	ENSG00000140259
	ENSMUSG00000068479
	P55081
	C0HKD8; C0HKD9
	NM_005926
	NM_026220
	NP_005917
	NP_001075444; NP_080496
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mikrofibrilama pridruženi protein 1 je protein koji je kod ljudi kodiran genom MFAP1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 439 aminokiselina, a molekulska težina 51.958 Da.^[7]

10	20	30	40	50
MSVPSALMKQ	PPIQSTAGAV	PVRNEKGEIS	MEKVKVKRYV	SGKRPDYAPM
ESSDEEDEEF	QFIKKAKEQE	AEPEEQEEDS	SSDPRLRRLQ	NRISEDVEER
LARHRKIVEP	EVVGESDSEV	EGDAWRMERE	DSSEEEEEEI	DDEEIERRRG
MMRQRAQERK	NEEMEVMEVE	DEGRSGEESE	SESEYEEYTD	SEDEMEPRLK
PVFIRKKDRV	TVQEREAEAL	KQKELEQEAK	RMAEERRKYT	LKIVEEETKK
ELEENKRSLA	ALDALNTDDE	NDEEEYEAWK	VRELKRIKRD	REDREALEKE
KAEIERMRNL	TEEERRAELR	ANGKVITNKA	VKGKYKFLQK	YYHRGAFFMD
EDEEVYKRDF	SAPTLEDHFN	KTILPKVMQV	KNFGRSGRTK	YTHLVDQDTT
SFDSAWGQES	AQNTKFFKQK	AAGVRDVFER	PSAKKRKTT

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140259 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068479 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yeh H, Chow M, Abrams WR, Fan J, Foster J, Mitchell H, Muenke M, Rosenbloom J (Feb 1995). "Structure of the human gene encoding the associated microfibrillar protein (MFAP1) and localization to chromosome 15q15-q21". Genomics. 23 (2): 443–9. doi:10.1006/geno.1994.1521. PMID 7835894.
^ "Entrez Gene: MFAP1 microfibrillar-associated protein 1".
^ "UniProt, P55081". Pristupljeno 16. 7. 2021.

Dopunska literatura

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. CiteSeerX 10.1.1.323.5263. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140259 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068479 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7835894-5] Yeh H, Chow M, Abrams WR, Fan J, Foster J, Mitchell H, Muenke M, Rosenbloom J (Feb 1995). "Structure of the human gene encoding the associated microfibrillar protein (MFAP1) and localization to chromosome 15q15-q21". Genomics. 23 (2): 443–9. doi:10.1006/geno.1994.1521. PMID 7835894.

[entrez-6] "Entrez Gene: MFAP1 microfibrillar-associated protein 1".

[UniProt-7] "UniProt, P55081". Pristupljeno 16. 7. 2021.

[1]

[2]

[3]

[4]

[5]

[6]

[7]