ARID4B

ARID4B
Identifikatori
Aliasi	ARID4B
Vanjski ID-jevi	OMIM: 609696 MGI: 2137512 HomoloGene: 12847 GeneCards: ARID4B
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	235,328,219 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	14,374,188 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • histone deacetylase activity; • molekularna funkcija; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• citoplazma; • nukleoplazma; • jedro; • ćelijska komponenta;
Biološki proces	• regulation of gene expression by genetic imprinting; • GO:0009373 regulation of transcription, DNA-templated; • establishment of Sertoli cell barrier; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • histone H4-K20 trimethylation; • transcription, DNA-templated; • histone H3-K9 trimethylation; • Spermatogeneza; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • histone deacetylation; • GO:0022610 biološki proces; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Izvori:Amigo / QuickGO
Ortolozi
	51742
	94246
	ENSG00000054267
	ENSMUSG00000039219
	Q4LE39
	A2CG63
	NM_001206794; NM_016374; NM_031371
	NM_194262; NM_198122
	NP_001193723; NP_057458; NP_112739
	NP_919238; NP_937755
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

AT-bogati protein 4B sa interaktivnim domenom jest protein koji je kod ljudi kodiran genom ARID4B sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.312 aminokiselina, a molekulska 147.809 težina Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKALDEPPYL	TVGTDVSAKY	RGAFCEAKIK	TAKRLVKVKV	TFRHDSSTVE
VQDDHIKGPL	KVGAIVEVKN	LDGAYQEAVI	NKLTDASWYT	VVFDDGDEKT
LRRSSLCLKG	ERHFAESETL	DQLPLTNPEH	FGTPVIGKKT	NRGRRSNHIP
EEESSSSSSD	EDEDDRKQID	ELLGKVVCVD	YISLDKKKAL	WFPALVVCPD
CSDEIAVKKD	NILVRSFKDG	KFTSVPRKDV	HEITSDTAPK	PDAVLKQAFE
QALEFHKSRT	IPANWKTELK	EDSSSSEAEE	EEEEEDDEKE	KEDNSSEEEE
EIEPFPEERE	NFLQQLYKFM	EDRGTPINKR	PVLGYRNLNL	FKLFRLVHKL
GGFDNIESGA	VWKQVYQDLG	IPVLNSAAGY	NVKCAYKKYL	YGFEEYCRSA
NIEFQMALPE	KVVNKQCKEC	ENVKEIKVKE	ENETEIKEIK	MEEERNIIPR
EEKPIEDEIE	RKENIKPSLG	SKKNLLESIP	THSDQEKEVN	IKKPEDNENL
DDKDDDTTRV	DESLNIKVEA	EEEKAKSGDE	TNKEEDEDDE	EAEEEEEEEE
EEEDEDDDDN	NEEEEFECYP	PGMKVQVRYG	RGKNQKMYEA	SIKDSDVEGG
EVLYLVHYCG	WNVRYDEWIK	ADKIVRPADK	NVPKIKHRKK	IKNKLDKEKD
KDEKYSPKNC	KLRRLSKPPF	QTNPSPEMVS	KLDLTDAKNS	DTAHIKSIEI
TSILNGLQAS	ESSAEDSEQE	DERGAQDMDN	NGKEESKIDH	LTNNRNDLIS
KEEQNSSSLL	EENKVHADLV	ISKPVSKSPE	RLRKDIEVLS	EDTDYEEDEV
TKKRKDVKKD	TTDKSSKPQI	KRGKRRYCNT	EECLKTGSPG	KKEEKAKNKE
SLCMENSSNS	SSDEDEEETK	AKMTPTKKYN	GLEEKRKSLR	TTGFYSGFSE
VAEKRIKLLN	NSDERLQNSR	AKDRKDVWSS	IQGQWPKKTL	KELFSDSDTE
AAASPPHPAP	EEGVAEESLQ	TVAEEESCSP	SVELEKPPPV	NVDSKPIEEK
TVEVNDRKAE	FPSSGSNSVL	NTPPTTPESP	SSVTVTEGSR	QQSSVTVSEP
LAPNQEEVRS	IKSETDSTIE	VDSVAGELQD	LQSEGNSSPA	GFDASVSSSS
SNQPEPEHPE	KACTGQKRVK	DAQGGGSSSK	KQKRSHKATV	VNNKKKGKGT
NSSDSEELSA	GESITKSQPV	KSVSTGMKSH	STKSPARTQS	PGKCGKNGDK
DPDLKEPSNR	LPKVYKWSFQ	MSDLENMTSA	ERITILQEKL	QEIRKHYLSL
KSEVASIDRR	RKRLKKKERE	SAATSSSSSS	PSSSSITAAV	MLTLAEPSMS
SASQNGMSVE	CR

Funkcija

Ovaj gen kodira protein sa sekvencom sličnosti sa retinoblastom-vezujućim proteinom-1. Kodirani protein je podjedinica histon-deacetilaza-ovisnog SIN3A transkripcijskog korepresorskog kompleksa, koji funkcioniše u različitim ćelijskim procesima, uključujući proliferaciju ćelija, diferencijaciju, apoptozu, onkogenezu i određivanje ćelijske sudbine Genski proizvod prepoznaje antitijelo IgG izolirano od raka dojke pacijenta i čini se da je molekulski marker povezan sa širokim spektrom ljudskih maligniteta. Karakterizirane su alternativne transkripcijske prerađene varijante koje kodiraju različite izoforme.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000054267 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039219 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cao J, Gao T, Stanbridge EJ, Irie R (Aug 2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis". J Natl Cancer Inst. 93 (15): 1159–65. doi:10.1093/jnci/93.15.1159. PMID 11481388.
^ ^a ^b "Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)".
^ "UniProt, Q4LE39" (jezik: en.). Pristupljeno 7. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease". J. Cell Biol. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMC 2173089. PMID 12446740.
Fleischer TC, Yun UJ, Ayer DE (2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Mol. Cell. Biol. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
Cui D, Jin G, Gao T, Sun T, Tian F, Estrada GG, Gao H, Sarai A (2004). "Characterization of BRCAA1 and its novel antigen epitope identification". Cancer Epidemiol. Biomarkers Prev. 13 (7): 1136–45. PMID 15247124.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

Vanjski linkovi

Lokacija ljudskog genoma ARID4B i stranica sa detaljima o genu ARID4B u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000054267 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039219 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11481388-5] Cao J, Gao T, Stanbridge EJ, Irie R (Aug 2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis". J Natl Cancer Inst. 93 (15): 1159–65. doi:10.1093/jnci/93.15.1159. PMID 11481388.

[entrez-6] "Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)".

[UniProt-7] "UniProt, Q4LE39" (jezik: en.). Pristupljeno 7. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[1]

[2]

[3]

[4]

[5]

[6]

[7]