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ATP2B4

S Wikipedije, slobodne enciklopedije
Datum izmjene: 5 januar 2022 u 10:39; autor: WumpusBot (razgovor | doprinosi) (razne ispravke)
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ATP2B4
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1CFF, 2KNE

Identifikatori
AliasiATP2B4
Vanjski ID-jeviOMIM: 108732 MGI: 88111 HomoloGene: 48034 GeneCards: ATP2B4
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za ATP2B4
Genomska lokacija za ATP2B4
Bend1q32.1Početak203,626,787 bp[1]
Kraj203,744,081 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za ATP2B4
Genomska lokacija za ATP2B4
Bend1 E4|1 57.95 cMPočetak133,627,195 bp[2]
Kraj133,728,779 bp[2]
Obrazac RNK ekspresije




Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija nucleotide binding
PDZ domain binding
sodium channel regulator activity
nitric-oxide synthase binding
scaffold protein binding
vezivanje iona metala
calmodulin binding
nitric-oxide synthase inhibitor activity
GO:0001948, GO:0016582 vezivanje za proteine
protein phosphatase 2B binding
ATP binding
hydrolase activity
P-type calcium transporter activity
protein kinase binding
Ćelijska komponenta integral component of membrane
projekcija ćelije
membrana
intracellular membrane-bounded organelle
T-tubule
ćelijska membrana
integral component of plasma membrane
sperm flagellum
sperm principal piece
basolateral plasma membrane
Z discdkac
Kaveole
neuron projection
Sarkolema
Treplja
motile cilium
GO:0009327 makromolekulani kompleks
glutamatergic synapse
integral component of presynaptic active zone membrane
Biološki proces negative regulation of nitric oxide mediated signal transduction
flagellated sperm motility
regulation of cardiac conduction
negative regulation of nitric-oxide synthase activity
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of citrulline biosynthetic process
negative regulation of peptidyl-cysteine S-nitrosylation
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
calcium ion import across plasma membrane
response to hydrostatic pressure
cellular calcium ion homeostasis
ion transport
positive regulation of peptidyl-serine phosphorylation
cellular response to epinephrine stimulus
ion transmembrane transport
negative regulation of nitric oxide biosynthetic process
calcium ion transmembrane transport
GO:0060401 calcium ion transmembrane import into cytosol
Spermatogeneza
positive regulation of cAMP-dependent protein kinase activity
regulation of cell cycle G1/S phase transition
regulation of sodium ion transmembrane transport
calcium ion export
hippocampus development
GO:0100045 negative regulation of arginine catabolic process
neural retina development
negative regulation of the force of heart contraction
calcium ion transport
negative regulation of cardiac muscle hypertrophy in response to stress
GO:0015915 transport
regulation of cytosolic calcium ion concentration
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
urinary bladder smooth muscle contraction
cellular response to acetylcholine
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001684
NM_001001396
NM_001365783
NM_001365784

NM_001167949
NM_213616

RefSeq (bjelančevina)

NP_001001396
NP_001675
NP_001352712
NP_001352713

NP_001161421
NP_998781

Lokacija (UCSC)Chr 1: 203.63 – 203.74 MbChr 1: 133.63 – 133.73 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Plazmamembranska kalcij-transportirajuća ATPaza 4 jest enzim koji je kod ljudi kodiran genom ATP2B4 sa hromosoma 1.[5][6]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 1.241 aminokiselina, a molekulska težina 137.920 Da.[7]

1020304050
MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGG
VQNLCSRLKTSPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEA
LQDVTLIILEIAAIISLVLSFYRPAGEENELCGQVATTPEDENEAQAGWI
EGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQ
LPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSL
DKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKK
GKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKS
VLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTP
IYIQYFVKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHL
DACETMGNATAICSDKTGTLTMNRMTVVQAYIGGIHYRQIPSPDVFLPKV
LDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDY
QAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRK
CNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEP
SWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNI
NTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKL
RVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDGTNDGPALKKADVGF
AMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTV
NVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLL
KRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKA
PLHSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSV
VLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGIGELLWGQFISAIP
TRSLKFLKEAGHGTTKEEITKDAEGLDEIDHAEMELRRGQILWFRGLNRI
QTQIDVINTFQTGASFKGVLRRQNMGQHLDVKLVPSSSYIKVVKAFHSSL
HESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEENPDKASKFGT
RVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV

Funkcija

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Protein kodiran ovim genom pripada familiji P-tipa primarnih transportnih iona ATPaza, koje karakterizira formiranje intermedijera aspartil-fosfata tokom reakcijskog ciklusa. Ovi enzimi uklanjaju dvovalentne ione kalcija iz eukariotskih ćelija protiv vrlo velikih gradijenata koncentracije i imaju ključnu ulogu u unutarćelijskoj homeostazi kalcija. Izoforme plazmamembranske kalcijske ATPaze sisara kodirane su sa najmanje četiri odvojena gena, a raznolikost ovih enzima je dodatno povećana alternativnom preradom transkripta. Ekspresija različitih izoformi i varijanti prerade regulirana je na način specifičan za razvoj, tkivo i tip sčelija, što sugerira da su ove pumpe funkcionalno prilagođene fiziološkim potrebama određenih ćelija i tkiva. Ovaj gen kodira izoformu 4 kalcijeve plazmamembranske ATPaze. Identificirane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.[6]

Interakcije

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Pokazalo se da ATP2B4 ima interakcije sa CASK.[8]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000058668 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026463 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Olson S, Wang MG, Carafoli E, Strehler EE, McBride OW (april 1991). "Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23". Genomics. 9 (4): 629–41. doi:10.1016/0888-7543(91)90356-J. PMID 1674727.
  6. ^ a b "Entrez Gene: ATP2B4 ATPase, Ca++ transporting, plasma membrane 4".
  7. ^ "UniProt, P23634" (jezik: en.). Pristupljeno 7. 12. 2021.CS1 održavanje: nepoznati jezik (link)
  8. ^ Schuh K, Uldrijan S, Gambaryan S, Roethlein N, Neyses L (mart 2003). "Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK". The Journal of Biological Chemistry. 278 (11): 9778–83. doi:10.1074/jbc.M212507200. PMID 12511555.

Dopunska literatura

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Vanjski linkovi

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Šablon:ATPaze