Parent Class:

EC-Numbers → 2 -- Transferases → 2.3 -- Acyltransferases → 2.3.3 -- Acyl groups converted into alkyl on transfer

Synonyms: (R)-citrate synthase, Re-citrate-synthase, citrate oxaloacetate-lyase [(pro-3R)-CH₂COO^-→acetyl-CoA]

Systematic Name: acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]

Unification Links: BRENDA:2.3.3.3, ENZYME:2.3.3.3, IUBMB-ExplorEnz:2.3.3.3

Supersedes EC number: 4.1.3.28

Reaction:
Reaction: EC 2.3.3.1/2.3.3.3/2.3.3.16 ID: CITSYN-RXN
acetyl-CoA + oxaloacetate + H₂O → citrate + coenzyme A + H⁺
acetyl-CoA_{[mitochondrial lumen]} + oxaloacetate_{[mitochondrial lumen]} + H₂O_{[mitochondrial lumen]} → citrate_{[mitochondrial lumen]} + coenzyme A_{[mitochondrial lumen]} + H⁺_{[mitochondrial lumen]}
acetyl-CoA_{[peroxisomal lumen]} + oxaloacetate_{[peroxisomal lumen]} + H₂O_{[peroxisomal lumen]} → citrate_{[peroxisomal lumen]} + coenzyme A_{[peroxisomal lumen]} + H⁺_{[peroxisomal lumen]}
Enzymes: citrate synthase [GltA]₆
citrate synthase CIT3
citrate synthase [AarA]₆
citrate synthase citZ
citrate synthase (mitochondrial) CSY4 [+ 6 isozymes]'>acetyl-CoA + oxaloacetate + H₂O → citrate + coenzyme A + H⁺

Summary:
The stereospecificity of this enzyme is opposite to that of EC 2.3.3.1, citrate (Si)-synthase. EC 2.3.3.1 is the usual citrate synthase of the citric acid cycle in animals and plants; EC 2.3.3.3 is found in some anaerobes.

Citations: [Gottschalk66, Dittbrenner69, Gottschalk69]

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References

Dittbrenner69: Dittbrenner S, Chowdhury AA, Gottschalk G (1969). "The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate." Biochem Biophys Res Commun 36(5);802-8. PMID: 5808294

Gottschalk66: Gottschalk G, Barker HA (1966). "Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase." Biochemistry 5(4);1125-33. PMID: 5958189

Gottschalk69: Gottschalk G (1969). "Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici." Eur J Biochem 7(2);301-6. PMID: 4974734

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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