络丝蛋白
络丝蛋白（英語：Reelin）是一种分泌于细胞外基质的大型糖蛋白，用于在大脑的发育中通过细胞-细胞相互作用调控神经元的迁移和定位。
参考文献
[编辑]- ^ PDB 2ddu; Nogi T, Yasui N, Hattori M, Iwasaki K, Takagi J. Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography. EMBO J. August 2006, 25 (15): 3675–83. PMC 1538547
. PMID 16858396. doi:10.1038/sj.emboj.7601240.
Recommended reading
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- The book: Fatemi, S. Hossein. Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. Berlin: Springer. 2008: 444 pages. ISBN 978-0-387-76760-4.
- A review: Förster E, Jossin Y, Zhao S, Chai X, Frotscher M, Goffinet AM. Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus. Eur. J. Neurosci. February 2006, 23 (4): 901–9. PMID 16519655. doi:10.1111/j.1460-9568.2006.04612.x.
外部链接
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Articles, publications, webpages
[编辑]- Gabriella D'Arcangelo. Rutgers University. [2008-08-23]. （原始内容存档于2008-07-25）.
the scientist who discovered the reelin gene and protein
- Human RELN at WikiGenes
Figures and images
[编辑]- Reelin gene expression in mice. Brain Gene Expression Map. St. Jude Children’s Research Hospital. [2008-08-23]. （原始内容存档于2005-01-23）.
- Schematic representation of signaling through the LDLR family members apoER2 and VLDL receptor. [2008-08-23].[永久失效連結] – A figure from Beffert U, Stolt PC, Herz J. Functions of lipoprotein receptors in neurons. J. Lipid Res. March 2004, 45 (3): 403–9. PMID 14657206. doi:10.1194/jlr.R300017-JLR200.
- Proposed mechanism by which mouse RELN promoter regulate reelin gene expression. Proc. Natl. Acad. Sci. USA. [2008-08-23]. （原始内容存档于2007-12-25）. – A figure from Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A. Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc. Natl. Acad. Sci. U.S.A. August 2005, 102 (35): 12578–83. PMC 1194936
- Corticogenesis in wild-type, reeler mutant and β1 deficient mice. [2008-08-23]. （原始内容存档于2007-12-24）.
Pictorial rendition of the difference that the lack of reelin brings to the cortical structure
– A figure from Magdaleno SM, Curran T. Brain development: integrins and the Reelin pathway. Curr. Biol. December 2001, 11 (24): R1032–5. PMID 11747842. doi:10.1016/S0960-9822(01)00618-2. - Effects of human and naturally occurring mouse RELN mutations on the predicted protein. Nature Genetics. [2008-08-23]. （原始内容存档于2007-12-15）. A figure from Hong SE; Shugart YY; Huang DT; et al. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Nat. Genet. September 2000, 26 (1): 93–6. PMID 10973257. doi:10.1038/79246.
- MRI analysis of chromosome 7q22-linked lissencephaly with cerebellar hypoplasia. Nature Genetics. [2008-08-23]. （原始内容存档于2007-12-15）. – A figure from Hong et al.