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Volume 12 (2); 2022

Research Papers

Graphic abstract

A transcriptional biosensor to monitor single cancer cell therapeutic responses by bioluminescence microscopy
Audrey Champagne, Pallavi Jain, Lauriane Vélot, Julie Riopel, Véronique Lefebvre, Bertrand Neveu, Frédéric Pouliot
Theranostics 2022; 12(2): 474-492. doi:10.7150/thno.63744
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Graphic abstract

Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury
Hong-Ru Chen, Ching-Wen Chen, Yi-Min Kuo, Brandon Chen, Irena S. Kuan, Henry Huang, Jolly Lee, Neil Anthony, Chia-Yi Kuan, Yu-Yo Sun
Theranostics 2022; 12(2): 512-529. doi:10.7150/thno.64033
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Graphic abstract

Modulation of H4K16Ac levels reduces pro-fibrotic gene expression and mitigates lung fibrosis in aged mice
Xiangyu Zhang, Hui Liu, Jennifer Q Zhou, Stefanie Krick, Jarrod W Barnes, Victor J Thannickal, Yan Y Sanders
Theranostics 2022; 12(2): 530-541. doi:10.7150/thno.62760
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Graphic abstract

Non-invasive longitudinal imaging of VEGF-induced microvascular alterations in skin wounds
Yu-Hang Liu, Lorenz M. Brunner, Johannes Rebling, Maya Ben-Yehuda Greenwald, Sabine Werner, Michael Detmar, Daniel Razansky
Theranostics 2022; 12(2): 558-573. doi:10.7150/thno.65287
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Graphic abstract

HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity
Blake R McAlpin, Rajasekaran Mahalingam, Anand K Singh, Shruti Dharmaraj, Taylor T Chrisikos, Nabila Boukelmoune, Annemieke Kavelaars, Cobi J Heijnen
Theranostics 2022; 12(2): 603-619. doi:10.7150/thno.67410
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Graphic abstract

Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer
Xuechun Li, Zhao Sun, Gongxin Peng, Yi Xiao, Junchao Guo, Bin Wu, Xiaoyi Li, Weixun Zhou, Jiarui Li, Zhe Li, Chunmei Bai, Lin Zhao, Qin Han, Robert Chunhua Zhao, Xiaoyue Wang
Theranostics 2022; 12(2): 620-638. doi:10.7150/thno.60540
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Graphic abstract

Antigen presentation and interferon signatures in B cells driven by localized ablative cancer immunotherapy correlate with extended survival
Kaili Liu, Ashley R. Hoover, Jason R. Krawic, Christa I. DeVette, Xiao-Hong Sun, William H. Hildebrand, Mark L. Lang, Robert C. Axtell, Wei R. Chen
Theranostics 2022; 12(2): 639-656. doi:10.7150/thno.65773
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Graphic abstract

Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization
Jiang-Hui Wang, Ching-Li Tseng, Fan-Li Lin, Jinying Chen, Erh-Hsuan Hsieh, Suraj Lama, Yu-Fan Chuang, Satheesh Kumar, Linxin Zhu, Myra B. McGuinness, Jessika Hernandez, Leilei Tu, Peng-Yuan Wang, Guei-Sheung Liu
Theranostics 2022; 12(2): 657-674. doi:10.7150/thno.65098
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Graphic abstract

β-glucan-coupled superparamagnetic iron oxide nanoparticles induce trained immunity to protect mice against sepsis
Yuchen Pan, Jingman Li, Xiaoyu Xia, Jiali Wang, Qi Jiang, Jingjing Yang, Huan Dou, Huaping Liang, Kuanyu Li, Yayi Hou
Theranostics 2022; 12(2): 675-688. doi:10.7150/thno.64874
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Graphic abstract

Loss of function of GATA3 induces basal-like mammary tumors
Feng Bai, Chenglong Zheng, Xiong Liu, Ho Lam Chan, Shiqin Liu, Jinshan Ma, Sijia Ren, Wei-Guo Zhu, Xin-Hai Pei
Theranostics 2022; 12(2): 720-733. doi:10.7150/thno.65796
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Graphic abstract

Ion drugs for precise orthotopic tumor management by in situ the generation of toxic ion and drug pools
Yushuo Feng, Ruixue Qin, Lihua Xu, Xiaoqian Ma, Dandan Ding, Shi Li, Lei Chen, Yaqing Liu, Wenjing Sun, Hongmin Chen
Theranostics 2022; 12(2): 734-746. doi:10.7150/thno.66468
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Graphic abstract

Nintedanib enhances the efficacy of PD-L1 blockade by upregulating MHC-I and PD-L1 expression in tumor cells
Jingyao Tu, Haoran Xu, Li Ma, Chunya Li, Wan Qin, Xinyi Chen, Ming Yi, Li Sun, Bo Liu, Xianglin Yuan
Theranostics 2022; 12(2): 747-766. doi:10.7150/thno.65828
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Graphic abstract

CXCR4 induces podocyte injury and proteinuria by activating β-catenin signaling
Hongyan Mo, Qian Ren, Dongyan Song, Bo Xu, Dong Zhou, Xue Hong, Fan Fan Hou, Lili Zhou, Youhua Liu
Theranostics 2022; 12(2): 767-781. doi:10.7150/thno.65948
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Graphic abstract

Resveratrol ameliorates polycystic ovary syndrome via transzonal projections within oocyte-granulosa cell communication
Mingyue Chen, Chengyong He, Kongyang Zhu, Zihan Chen, Zixiao Meng, Xiaoming Jiang, Jiali Cai, Chunyan Yang, Zhenghong Zuo
Theranostics 2022; 12(2): 782-795. doi:10.7150/thno.67167
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Graphic abstract

FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape
Lei Wu, Yanquan Xu, Huakan Zhao, Yu Zhou, Yu Chen, Shuai Yang, Juan Lei, Jiangang Zhang, Jingchun Wang, Yongzhong Wu, Yongsheng Li
Theranostics 2022; 12(2): 842-858. doi:10.7150/thno.66575
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Extracellular ATP is increased by release of ATP-loaded microparticles triggered by nutrient deprivation
Valentina Vultaggio-Poma, Simonetta Falzoni, Paola Chiozzi, Alba Clara Sarti, Elena Adinolfi, Anna Lisa Giuliani, Alejandro Sánchez-Melgar, Paola Boldrini, Michele Zanoni, Anna Tesei, Paolo Pinton, Francesco Di Virgilio
Theranostics 2022; 12(2): 859-874. doi:10.7150/thno.66274
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Graphic abstract

5-aza-2′-deoxycytidine potentiates anti-tumor immunity in colorectal peritoneal metastasis by modulating ABC A9-mediated cholesterol accumulation in macrophages
Rongchen Shi, Kun Zhao, Teng Wang, Jing Yuan, Dapeng Zhang, Wei Xiang, Jin Qian, Na Luo, Yong Zhou, Bo Tang, Chuan Li, Hongming Miao
Theranostics 2022; 12(2): 875-890. doi:10.7150/thno.66420
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Graphic abstract

Dysregulation of interaction between LOXhigh fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissection
Yinan Chen, Tao Zhang, Fang Yao, Xiang Gao, Dandan Li, Shufang Fu, Lin Mao, Fei Liu, Xuelin Zhang, Yongle Xu, Jianqing Deng, Weihao Li, Guangpu Fan, Cangsong Xiao, Yu Chen, Li Wang, Wei Guo, Bingying Zhou
Theranostics 2022; 12(2): 910-928. doi:10.7150/thno.66059
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Suppression of breast cancer-associated bone loss with osteoblast proteomes via Hsp90ab1/moesin-mediated inhibition of TGFβ/FN1/CD44 signaling
Xun Sun, Kexin Li, Misato Hase, Rongrong Zha, Yan Feng, Bai-Yan Li, Hiroki Yokota
Theranostics 2022; 12(2): 929-943. doi:10.7150/thno.66148
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Tumor-specific activatable biopolymer nanoparticles stabilized by hydroxyethyl starch prodrug for self-amplified cooperative cancer therapy
Yuxuan Xiong, Zibing Wang, Qiang Wang, Qingyuan Deng, Jitang Chen, Jianshuang Wei, Xiaoquan Yang, Xiangliang Yang, Zifu Li
Theranostics 2022; 12(2): 944-962. doi:10.7150/thno.67572
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Graphic abstract

HMGA2 facilitates colorectal cancer progression via STAT3-mediated tumor-associated macrophage recruitment
Xin Wang, Jian Wang, Jiahui Zhao, Hao Wang, Jing Chen, Jingjing Wu
Theranostics 2022; 12(2): 963-975. doi:10.7150/thno.65411
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Graphic abstract

Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation
Rongqing Li, Xueqin Li, Jie Zhao, Fandong Meng, Chen Yao, Ensi Bao, Na Sun, Xin Chen, Wanpeng Cheng, Hui Hua, Xiangyang Li, Bo Wang, Hui Wang, Xiucheng Pan, Hongjuan You, Jing Yang, Takayuki Ikezoe
Theranostics 2022; 12(2): 976-998. doi:10.7150/thno.63751
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Reviews

Graphic abstract

Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices
Salvatore Andrea Pullano, Marta Greco, Maria Giovanna Bianco, Daniela Foti, Antonio Brunetti, Antonino S. Fiorillo
Theranostics 2022; 12(2): 493-511. doi:10.7150/thno.64035
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Graphic abstract

Light on osteoarthritic joint: from bench to bed
Yingying Zhou, Junguo Ni, Chunyi Wen, Puxiang Lai
Theranostics 2022; 12(2): 542-557. doi:10.7150/thno.64340
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Graphic abstract

Tailoring noble metal nanoparticle designs to enable sensitive lateral flow immunoassay
Xirui Chen, Lu Ding, Xiaolin Huang, Yonghua Xiong
Theranostics 2022; 12(2): 574-602. doi:10.7150/thno.67184
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Graphic abstract

Dodging blood brain barrier with “nano” warriors: Novel strategy against ischemic stroke
Suhel Parvez, Medha Kaushik, Mubashshir Ali, Mohammad Mumtaz Alam, Javed Ali, Heena Tabassum, Pooja Kaushik
Theranostics 2022; 12(2): 689-719. doi:10.7150/thno.64806
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Graphic abstract

Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle
Yue Huang, Jessica C. Hsu, Hyun Koo, David P. Cormode
Theranostics 2022; 12(2): 796-816. doi:10.7150/thno.67375
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Graphic abstract

Targeting regulated cell death in tumor nanomedicines
Qinghu Zeng, Xiangyi Ma, Yangmeihui Song, Qiqing Chen, Qiuling Jiao, Liqiang Zhou
Theranostics 2022; 12(2): 817-841. doi:10.7150/thno.67932
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Graphic abstract

Emerging microfluidics-enabled platforms for osteoarthritis management: from benchtop to bedside
Zhou Zou, Xiaohe Luo, Zhengkun Chen, Yu Shrike Zhang, Chunyi Wen
Theranostics 2022; 12(2): 891-909. doi:10.7150/thno.62685
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