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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.


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Review
Advances in subpopulation separation and detection of extracellular vesicles: for liquid biopsy and downstream research
Zi-Xiu Liu, Gang Chen, Zi-Li Yu
Theranostics 2025; 15(3): 1135-1155. doi:10.7150/thno.106459
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Research Paper
Drug repositioning of mesalamine via supramolecular nanoassembly for the treatment of drug-induced acute liver failure
Byeongmin Park, Eun Hye Kim, Hochung Jang, Yelee Kim, Youngri Ryu, Jiwoong Choi, Dongwon Shin, Myung Chul Lee, Yoosoo Yang, Kwangmeyung Kim, Sangmin Lee, Sun Hwa Kim, Man Kyu Shim
Theranostics 2025; 15(3): 1122-1134. doi:10.7150/thno.101358
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Research Paper
Non-invasive volumetric ultrasound localization microscopy detects vascular changes in mice with Alzheimer's disease
Rebecca M. Jones, Ryan M. DeRuiter, Mohanish Deshmukh, Paul A. Dayton, Gianmarco F. Pinton
Theranostics 2025; 15(3): 1110-1121. doi:10.7150/thno.99097
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Research Paper
A specific and adaptable approach to track CD206+ macrophages by molecular MRI and fluorescence imaging
Cuihua Wang, Negin Jalali Motlagh, Gregory R. Wojtkiewicz, Hongzhi Yang, Hyung-Hwan Kim, John W. Chen
Theranostics 2025; 15(3): 1094-1109. doi:10.7150/thno.96488
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Research Paper
Perfluorocarbon-polyepinephrine core-shell nanoparticles as a near-infrared light activatable theranostic platform for bimodal imaging-guided photothermal/chemodynamic synergistic cancer therapy
Kyung Kwan Lee, Kyung-Woo Park, Sang Cheon Lee, Chang-Soo Lee
Theranostics 2025; 15(3): 1077-1093. doi:10.7150/thno.102743
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Research Paper
Bisphosphonate-mineralized nano-IFNγ suppresses residual tumor growth caused by incomplete radiofrequency ablation through metabolically remodeling tumor-associated macrophages
Zhicheng Yan, Bing Wang, Yuhan Shen, Junji Ren, Meifang Chen, Yunhui Jiang, Hao Wu, Wenbing Dai, Hua Zhang, Xueqing Wang, Qiang Zhang, Wei Yang, Bing He
Theranostics 2025; 15(3): 1057-1076. doi:10.7150/thno.100998
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Editor-in-Chief:
Xiaoyuan (Shawn) Chen, PhD
Editor-in-chief profile

Congratulations! Professor Chen has been elected as a member of the Academia Europaea.



Background: Activatable multifunctional nanoparticles present considerable advantages in cancer treatment by integrating both diagnostic and therapeutic functionalities into a single platform. These nanoparticles can be precisely engineered to selectively target cancer cells, thereby reducing the risk of damage to healthy tissues. Once localized at the target site, they can be activated by external stimuli such as light, pH changes, or specific enzymes, enabling precise control over the release of therapeutic agents or the initiation of therapeutic effects. Furthermore, these nanoparticles can....
Rationale: Acute liver failure (ALF) is characterized by rapid hepatic dysfunction, primarily caused by drug-induced hepatotoxicity. Due to the lack of satisfactory treatment options, ALF remains a fatal clinical disease, representing a grand challenge in global health. Methods: For the drug repositioning to ALF of mesalamine, which is clinically approved for the treatment of inflammatory bowel disease (IBD), we propose a supramolecular prodrug nanoassembly (SPNs). Mesalamine is modified with a functional peptide of the FRRG sequence. The resulting mesalamine prodrugs form nanoassemblies solely....

Nanotheranostics is indexed in MEDLINE and PubMed Central ...

Research Paper
Therapeutic Potential of Feline Adipose-Derived Stem Cell Exosomes in the Treatment of Feline Idiopathic Cystitis: A Characterization and Functional Analysis of miRNA Content
Andrea Rubini, Federica Zanotti, Danilo Licastro, Giulia Calogero, Gisella Bettini, Cristiana Piccoli, Giuseppe Rubini, Luca Lovatti, Barbara Zavan
Nanotheranostics 2025; 9(1): 38-51.
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