Integrins: bidirectional, allosteric signaling machines (Q27860700)

https://doi.org/10.1016%2FS0092-8674%2802%2900971-6

integrin alpha1-beta1 complex

1 May 2017

main subject

1 reference

integrin alphav-beta3 complex

GO:0034665

1 reference

integrin alphav-beta5 complex

GO:0034683

1 reference

integrin alpha3-beta1 complex

GO:0034684

1 reference

integrin alpha2-beta1 complex

GO:0034667

1 reference

integrin alphaX-beta2 complex

GO:0034666

1 reference

integrin alphav-beta6 complex

GO:0034689

1 reference

integrin alphav-beta8 complex

GO:0034685

1 reference

integrin alphaD-beta2 complex

GO:0034686

1 reference

integrin alpha9-beta1 complex

GO:0034690

1 reference

integrin alpha8-beta1 complex

GO:0034679

1 reference

integrin alphaE-beta7 complex

GO:0034678

1 reference

integrin alpha5-beta1 complex

GO:0034691

1 reference

integrin alpha4-beta7 complex

GO:0034674

1 reference

integrin alpha11-beta1 complex

GO:0034669

1 reference

integrin alphaIIb-beta3 complex

GO:0034681

1 reference

integrin alphaM-beta2 complex

GO:0070442

1 reference

integrin alpha6-beta4 complex

GO:0034688

1 reference

integrin alpha6-beta1 complex

GO:0034676

1 reference

integrin alpha7-beta1 complex

GO:0034675

1 reference

integrin alphav-beta1 complex

GO:0034677

1 reference

integrin alpha10-beta1 complex

GO:0034682

1 reference

integrin alphaL-beta2 complex

GO:0034680

1 reference

integrin alpha4-beta1 complex

GO:0034687

1 reference

Richard O Hynes

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language of work or name

English

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publication date

20 September 2002

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September 2002

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https://doi.org/10.1016%2FS0092-8674%2802%2900971-6

1 May 2017

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https://doi.org/10.1016%2FS0092-8674%2802%2900971-6

1 May 2017

volume

110

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https://doi.org/10.1016%2FS0092-8674%2802%2900971-6

1 May 2017

issue

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https://doi.org/10.1016%2FS0092-8674%2802%2900971-6

1 May 2017

page(s)

673-87

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673-687

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https://doi.org/10.1016%2FS0092-8674%2802%2900971-6

Does the integrin alphaA domain act as a ligand for its betaA domain?

1 May 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Determination of the Border between the Transmembrane and Cytoplasmic Domains of Human Integrin Subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Anchorage-dependent cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Are changes in integrin affinity and conformation overemphasized?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Rap1 signalling: adhering to new models

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Functional consequences of integrin gene mutations in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrin-associated protein (CD47) and its ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Invertebrate integrins: structure, function, and evolution.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Focal adhesions, contractility, and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

The phosphotyrosine binding-like domain of talin activates integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrins and signal transduction pathways: the road taken

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Activation affects access to the platelet receptor for adhesive glycoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Platelet GPIIb/IIIa antagonists: the first anti-integrin receptor therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Fibronectin, integrins, and growth control

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrin and ECM functions: roles in vertebrate development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Crystal Structure of the I Domain from Integrin α2β1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Structural basis of collagen recognition by integrin alpha2beta1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Complementation of dominant suppression implicates CD98 in integrin activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

1 reference

7 January 2021

Distinct activation states of alpha5beta1 integrin show differential binding to RGD and synergy domains of fibronectin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

1 reference

7 January 2021

Inside-out integrin signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrin associated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Specific tetraspanin functions

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Genetic analysis of integrin function in man: LAD-1 and other syndromes.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Evolution of the integrin alpha and beta protein families.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrin affinity modulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

1 reference

7 January 2021

Insights into integrin-ligand binding and activation from the first crystal structure.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrins: a family of cell surface receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrins: versatility, modulation, and signaling in cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Targeted mutations in cell adhesion genes: what have we learned from them?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

A reevaluation of integrins as regulators of angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

The evolution of cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Alpha 4 integrin antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

The biologic and clinical spectrum of Glanzmann's Thrombasthenia: implications of integrin αIIbβ3 for its pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Beta1 integrins show specific association with CD98 protein in low density membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

The 2.0 A crystal structure of a heterotrimeric G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Cell migration: a physically integrated molecular process

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Will the real integrin please stand up?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrin activation takes shape

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Cell adhesion in vascular biology. New insights into integrin-ligand interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Sensing the environment: a historical perspective on integrin signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

The platelet integrin alpha IIbbeta 3 has an endogenous thiol isomerase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrin cytoplasmic domains mediate inside-out signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Ligand binding to integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Mutation analysis and molecular genetics of epidermolysis bullosa

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Leukocyte-endothelial cell interactions - lessons from knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Bidirectional signaling between the cytoskeleton and integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Networks and crosstalk: integrin signalling spreads.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrins: emerging paradigms of signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

In vivo functions of integrins: lessons from null mutations in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Conformational regulation of integrin structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Crystal structure of a G-protein beta gamma dimer at 2.1A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Evolution of von Willebrand factor A (VWA) domains

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Divalent Cations Differentially Regulate Integrin αIIbCytoplasmic Tail Binding to β3and to Calcium- and Integrin-binding Protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Function and interactions of integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

The inner world of cell adhesion: integrin cytoplasmic domains

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Crystal structure of the extracellular segment of integrin alpha Vbeta3

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrin transmembrane signaling and cytoskeletal control

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

A redox site involved in integrin activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Mechanism of integrin activation by disulfide bond reduction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

Integrin activation by R-ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900971-6

7 January 2021

10.1016/S0092-8674(02)00971-6

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

https://doi.org/10.1016%2FS0092-8674%2802%2900971-6

1 May 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12297042

1 reference

Consolidated OpenCitations Corpus – April 2017