CD40 molecule (Q21135811)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25942

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Tumour necrosis factor receptor 5, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TNFR/NGFR cysteine-rich region, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

signal transducer activity

1 reference

31 October 2017

Reduction of atherosclerosis in mice by inhibition of CD40 signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25942&geneProductId=UniProtKB:P25942

protein binding

7 references

8 April 2019

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

8 April 2019

A novel RING finger protein interacts with the cytoplasmic domain of CD40

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

8 April 2019

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

8 April 2019

OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

8 April 2019

Distinct molecular mechanism for initiating TRAF6 signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

tumor necrosis factor-activated receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25942&geneProductId=UniProtKB:P25942

1 reference

31 October 2017

enzyme binding

1 reference

8 April 2019

Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

ubiquitin protein ligase binding

1 reference

8 April 2019

A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

protein domain specific binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

cell component

cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

1 reference

8 April 2019

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

5 references

8 April 2019

8 April 2019

Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

integral component of plasma membrane

1 reference

8 April 2019

Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

1 reference

8 April 2019

extracellular exosome

1 reference

31 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25942&geneProductId=UniProtKB:P25942

extracellular space

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

soma

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

varicosity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

extracellular exosome

HDA

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

positive regulation of protein phosphorylation

HDA

biological process

1 reference

8 April 2019

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

positive regulation of MAP kinase activity

1 reference

8 April 2019

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

positive regulation of interleukin-12 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

protein kinase B signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

positive regulation of protein kinase C signaling

1 reference

8 April 2019

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

1 reference

8 April 2019

tumor necrosis factor-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

1 reference

8 April 2019

immune response-regulating cell surface receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

platelet activation

1 reference

8 April 2019

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25942&geneProductId=UniProtKB:P25942

1 reference

31 October 2017

positive regulation of GTPase activity

1 reference

8 April 2019

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

response to lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25942&geneProductId=UniProtKB:P25942

1 reference

31 October 2017

B cell proliferation

1 reference

8 April 2019

Cleavage of membrane-bound CD40 ligand is not required for inducing B cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

cellular response to mechanical stimulus

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

positive regulation of endothelial cell apoptotic process

1 reference

8 April 2019

A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

regulation of cell population proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25942&geneProductId=UniProtKB:P25942

1 reference

31 October 2017

positive regulation of B cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

positive regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

defense response to virus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25942&geneProductId=UniProtKB:P25942

1 reference

31 October 2017

regulation of immune response

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

apoptotic signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25942&geneProductId=UniProtKB:P25942

1 reference

31 October 2017

positive regulation of isotype switching to IgG isotypes

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

cellular response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

defense response to protozoan

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

response to bacterium

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

response to nutrient levels

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

response to cobalamin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

response to interferon-gamma

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

cellular response to erythropoietin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

cellular response to interleukin-1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

cellular response to tumor necrosis factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

response to peptide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

inflammatory response

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25942&geneProductId=UniProtKB:P25942

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25942&geneProductId=UniProtKB:P25942

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25942&geneProductId=UniProtKB:P25942

31 October 2017

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

8 April 2019

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

positive regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

positive regulation of angiogenesis

1 reference

8 April 2019

A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

protein-containing complex assembly

1 reference

8 April 2019

Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25942

TNFR/NGFR cysteine-rich region

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25942

Tumour necrosis factor receptor 5, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25942

Identifiers

MeSH descriptor ID

D019013

subject named as

CD40 Antigens

0 references

MeSH tree code

D12.776.543.750.705.852.760.097

0 references

D23.050.301.264.051.140

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023