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General
Preferred name
GLPG-0187
Synonyms
GLPG0187 ()
GLPG 0187 ()
Glpg0187 ()
P&D ID
PD058153
CAS
1320346-97-1
Tags
available
natural product
drug candidate
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent and selective JAK1/JAK2 inhibitor; orally bioavailable (Tocris Bioactive Compound Library)
Compound Sets
8
Cayman Chemical Bioactives
21792
ChEMBL Drugs
CHEMBL3319236
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB12297
MedChem Express Bioactive Compound Library
HY-100506
TargetMol Bioactive Compound Library
T4259
Tocris Bioactive Compound Library
7059
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
595.26
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
4
Rotatable Bonds
10
Ring Count
5
Aromatic Ring Count
3
cLogP
3.08
TPSA
158.67
Fraction CSP3
0.45
Chiral centers
1.0
Largest ring
6.0
QED
0.27
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cytoskeletal Signaling
cytoskeleton
Target
??V??1 integrin
¦Áv¦Â1 integrin
Primary Target
Integrins
MOA
Integrin
Inhibitor
Integrin antagonist
Source data