A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion

Front Mol Biosci. 2021 Dec 24:8:763338. doi: 10.3389/fmolb.2021.763338. eCollection 2021.

Authors

Soudeh Ghafouri-Fard¹, Tayyebeh Khoshbakht², Bashdar Mahmud Hussen³, Mohammad Taheri^{4

5}, Mohammad Samadian⁶

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Iraq.
⁴ Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁵ Institute of Human Genetics, Jena University Hospital, Jena, Germany.
⁶ Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

MicroRNAs (miRNAs) have been shown to affect expression of several genes contributing in important biological processes. miR-1290 a member of this family with crucial roles in the carcinogenesis. This miRNA is transcribed from MIR1290 gene on chromosome 1p36.13. This miRNA has interactions with a number of mRNA coding genes as well as non-coding RNAs SOCS4, GSK3, BCL2, CCNG2, KIF13B, INPP4B, hMSH2, KIF13B, NKD1, FOXA1, IGFBP3, CCAT1, FOXA1, NAT1, SMEK1, SCAI, ZNF667-AS1, ABLIM1, Circ_0000629 and CDC73. miR-1290 can also regulate activity of JAK/STAT3, PI3K/AKT, Wnt/β-catenin and NF-κB molecular pathways. Most evidence indicates the oncogenic roles of miR-1290, yet controversial evidence also exists. In the present review, we describe the results of in vitro, animal and human investigations about the impact of miR-1290 in the development of malignancies.

Keywords: biomarker; cancer; expression; miR-1290; miRNA.

Publication types

Review