Development of a validated glenoid trabecular density-modulus relationship

J Mech Behav Biomed Mater. 2019 Feb:90:140-145. doi: 10.1016/j.jmbbm.2018.10.013. Epub 2018 Oct 12.

Authors

Nikolas K Knowles¹, G Daniel G Langohr², Mohammadreza Faieghi³, Andrew Nelson⁴, Louis M Ferreira⁵

Affiliations

¹ School of Biomedical Engineering, The University of Western Ontario, London, ON, Canada; Roth McFarlane Hand and Upper Limb Centre, St. Josephs Health Care, London, ON, Canada; Collaborative Training Program in MSK Health Research, and Bone and Joint Institute, The University of Western Ontario, London, ON, Canada.
² Department of Mechanical and Materials Engineering, The University of Western Ontario, London, ON, Canada; Roth McFarlane Hand and Upper Limb Centre, St. Josephs Health Care, London, ON, Canada; Collaborative Training Program in MSK Health Research, and Bone and Joint Institute, The University of Western Ontario, London, ON, Canada.
³ School of Biomedical Engineering, The University of Western Ontario, London, ON, Canada.
⁴ Department of Anthropology and Chemistry, The University of Western Ontario, London, ON, Canada; Collaborative Training Program in MSK Health Research, and Bone and Joint Institute, The University of Western Ontario, London, ON, Canada.
⁵ Department of Mechanical and Materials Engineering, The University of Western Ontario, London, ON, Canada; Roth McFarlane Hand and Upper Limb Centre, St. Josephs Health Care, London, ON, Canada; Collaborative Training Program in MSK Health Research, and Bone and Joint Institute, The University of Western Ontario, London, ON, Canada. Electronic address: Louis.Ferreira@sjhc.london.on.ca.

PMID: 30366304
DOI: 10.1016/j.jmbbm.2018.10.013

Abstract

Incorporating subject-specific mechanical properties derived from clinical-resolution computed tomography data increases the accuracy of finite element models. Site-specific relationships between density and modulus are required due to variations in trabecular architecture and tissue density by anatomic location. Equations have been developed for many anatomic locations and have been shown to have excellent statistical agreement with empirical results; however, a shoulder-specific density-modulus relationship does not currently exist. This study used micro-finite element cores of glenoid trabecular bone and co-registered quantitative computed tomography finite element models to develop a validated glenoid trabecular density-modulus relationship. Micro finite element model tissue density was considered as either homogeneous or heterogeneous, scaled by CT-intensity. When heterogeneous tissue density was considered, near absolute statistical agreement was predicted in the co-registered QCT-derived finite element models. The validated relationships have also been adapted for use in whole bone scapular models and have the potential to dramatically increase the accuracy of clinical-resolution CT-derived shoulder finite element studies.

Keywords: Density-modulus; Finite element modeling; Glenoid; Micro computed tomography; Quantitative computed tomography; Trabecular bone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Biomechanical Phenomena
Cancellous Bone* / diagnostic imaging
Female
Finite Element Analysis*
Humans
Male
Mechanical Phenomena*
Middle Aged
Scapula / diagnostic imaging
X-Ray Microtomography