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Diffuse Large B Cell Lymphoma in a Prosthetic Aortic Graft

Heart Lung Circ. 2017 Feb;26(2):e4-e6. doi: 10.1016/j.hlc.2016.07.010. Epub 2016 Aug 31.

Abstract

We describe the case of a 70-year-old man with Marfan Syndrome who was found to have Diffuse Large B Cell Lymphoma (DLBCL) within an ascending aortic graft, his native aortic arch and arch vessels. Ten years previously he had undergone a Bentall's Procedure for a dilated aortic root. He presented with a left middle cerebral artery stroke. Computed tomography (CT) scan revealed multiple filling defects within the aortic arch and branch vessels suggestive of thrombus. Following the stroke, his neurological deficit improved. A decision was made to perform an aortic arch replacement to reduce the risk of a further embolic event. Subsequent histopathology confirmed DLBCL. Intravascular DLBCL is an extremely rare entity but an important diagnosis to consider in patients with intra-aortic thrombus in proximity to prosthetic graft material.

Keywords: Aortic arch; Lymphoma; Prosthetic graft; Thrombus.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aorta* / pathology
  • Aorta* / surgery
  • Blood Vessel Prosthesis / adverse effects*
  • Humans
  • Lymphoma, Large B-Cell, Diffuse* / pathology
  • Lymphoma, Large B-Cell, Diffuse* / surgery
  • Male
  • Marfan Syndrome / pathology
  • Marfan Syndrome / surgery*
  • Vascular Neoplasms* / pathology
  • Vascular Neoplasms* / surgery