A potent alpha-glucosidase inhibitor from Myristica cinnamomea King

Phytochemistry. 2016 Feb:122:265-269. doi: 10.1016/j.phytochem.2015.12.007. Epub 2015 Dec 19.

Authors

Yasodha Sivasothy¹, Kong Yong Loo², Kok Hoong Leong², Marc Litaudon³, Khalijah Awang⁴

Affiliations

¹ Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
² Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
³ Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France.
⁴ Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: khalijah@um.edu.my.

PMID: 26712615
DOI: 10.1016/j.phytochem.2015.12.007

Abstract

A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC50 5.05μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC50 358.80μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver-Burk plot of giganteone D indicated that it was a mixed-type inhibitor. This is the first report on the α-glucosidase inhibiting potential of acylphenols.

Keywords: Acylphenol; Cinnamomeone A; Dimeric acylphenol; Giganteone D; Myristica cinnamomea King; Myristicaceae; α-Glucosidase inhibitor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Glycoside Hydrolase Inhibitors / chemistry
Glycoside Hydrolase Inhibitors / isolation & purification*
Glycoside Hydrolase Inhibitors / pharmacology*
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / isolation & purification*
Hypoglycemic Agents / pharmacology*
Myristicaceae / chemistry*
Nuclear Magnetic Resonance, Biomolecular
Plant Bark / chemistry
alpha-Glucosidases / drug effects*

Substances

Glycoside Hydrolase Inhibitors
Hypoglycemic Agents
alpha-Glucosidases