Bifunctionalized mesoporous silica-supported gold nanoparticles: intrinsic oxidase and peroxidase catalytic activities for antibacterial applications

Adv Mater. 2015 Feb 11;27(6):1097-104. doi: 10.1002/adma.201405105. Epub 2014 Dec 8.

Authors

Yu Tao¹, Enguo Ju, Jinsong Ren, Xiaogang Qu

Affiliation

¹ State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Changchun, 130022, China; Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, 130022, China.

PMID: 25655182
DOI: 10.1002/adma.201405105

Abstract

Bifunctionalized mesoporous silica-supported gold nanoparticles as oxidase and peroxidase mimics for antibacterial applications are demonstrated. For the first time, these mesoporous silica-supported gold nanoparticles are applied as oxidase and peroxidase mimics. Taking advantage of their prominent enzyme activities, the MSN-AuNPs show excellent antibacterial properties against both Gram-negative and Gram-positive bacteria. Furthermore, MSN-AuNPs also exhibit outstanding performance in biofilm elimination .

Keywords: antibacterial agents; bifunctionalization; gold nanoparticles; mesoporous silica; oxidase and peroxidase catalytic activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adsorption
Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / pharmacology
Bacterial Physiological Phenomena / drug effects*
Biofilms / drug effects
Biofilms / growth & development
Biomimetic Materials / chemical synthesis
Catalysis
Cell Survival / drug effects
Enzyme Activation
Gold / administration & dosage
Gold / chemistry*
Materials Testing
Metal Nanoparticles / administration & dosage*
Metal Nanoparticles / chemistry*
Metal Nanoparticles / ultrastructure
Nanopores / ultrastructure
Oxidoreductases / chemistry*
Peroxidase / chemistry*
Porosity
Silicon Dioxide / chemistry

Substances

Anti-Bacterial Agents
Gold
Silicon Dioxide
Oxidoreductases
Peroxidase