Abstract
A series of chalcones was evaluated as antimitotic agents. One of these, (E)-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2-pr open- 1-one) (73), was found to be an effective antimitotic agent at a concentration of 4 nM in an in vitro HeLa cell test system. When evaluated in experimental tumor models in vivo, this compound exhibited antitumor activity against L1210 leukemia and B16 melanoma.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Cell Cycle / drug effects
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Chalcone / analogs & derivatives
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Chalcone / chemical synthesis*
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Chalcone / pharmacology
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HeLa Cells / cytology
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HeLa Cells / drug effects
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Humans
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Mitosis / drug effects
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Molecular Structure
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Propiophenones / chemical synthesis*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Indicators and Reagents
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Propiophenones
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MDL 27048
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Chalcone