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Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells

Semin Cancer Biol. 2012 Aug;22(4):282-8. doi: 10.1016/j.semcancer.2012.01.010. Epub 2012 Jan 31.

Abstract

Myeloid derived suppressor cells play a critical role in T cell suppression in cancer. Here, we discuss the mechanisms of how MDSC suppress CD4(+) or CD8(+) T cells in an antigen dependent or non-dependent manner.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antigens, Neoplasm / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology
  • Humans
  • Immune Tolerance
  • Myeloid Cells / immunology*
  • Neoplasms / immunology*
  • Tumor Escape

Substances

  • Antigens, Neoplasm