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Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis

Stud Health Technol Inform. 2012:176:52-5.

Abstract

MESP2, HES7 and DUSP6 genes have been proved to be involved in the etiopathogenesis of congenital scoliosis (CS) in animal embryo studies, however, whether this association was detected in human CS patients also remains unknown. One hundred sporadic and non-syndromic CS patients and 100 age-matched normal controls were included in this study. Mutation screening of gene exons were performed by DNA sequencing. However, no mutation or new single nucleotide polymorphism was found in the exons of MESP2, HES7 and DUSP6 genes in CS patients and normal controls. MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.

MeSH terms

  • Adolescent
  • Basic Helix-Loop-Helix Transcription Factors / genetics*
  • China / epidemiology
  • Dual Specificity Phosphatase 6 / genetics*
  • Exons / genetics
  • Female
  • Genetic Predisposition to Disease / epidemiology*
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Male
  • Mutation / genetics
  • Polymorphism, Single Nucleotide / genetics
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • Scoliosis / congenital*
  • Scoliosis / epidemiology*

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • HES7 protein, human
  • MESP2 protein, human
  • DUSP6 protein, human
  • Dual Specificity Phosphatase 6