Abstract
Clearance and adverse effects of efavirenz are associated with CYP2B6-G516T polymorphism. Little is known about the prevalence of genotypes and implications for screening in children. We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.
MeSH terms
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Alkynes
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Aryl Hydrocarbon Hydroxylases / genetics
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Benzoxazines / adverse effects*
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Benzoxazines / blood
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Benzoxazines / therapeutic use
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Child
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Cyclopropanes
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Cytochrome P-450 CYP2B6
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Female
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HIV Infections / complications*
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HIV Infections / drug therapy
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Heterozygote
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Humans
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Oxidoreductases, N-Demethylating / genetics
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Point Mutation
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Psychoses, Substance-Induced / etiology*
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Reverse Transcriptase Inhibitors / adverse effects*
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Reverse Transcriptase Inhibitors / blood
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Reverse Transcriptase Inhibitors / therapeutic use
Substances
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Alkynes
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Benzoxazines
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Cyclopropanes
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Reverse Transcriptase Inhibitors
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Aryl Hydrocarbon Hydroxylases
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CYP2B6 protein, human
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Cytochrome P-450 CYP2B6
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Oxidoreductases, N-Demethylating
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efavirenz