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Novel therapeutic approaches for heart failure by normalizing calcium cycling

Nat Rev Drug Discov. 2004 Jul;3(7):565-73. doi: 10.1038/nrd1440.

Authors

Xander H T Wehrens¹, Andrew R Marks

Affiliation

¹ Department of Physiology and Cellular Biophysics, Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, 630W 168th Street, P&S 9-401, New York, New York 10032, USA.

PMID: 15232578
DOI: 10.1038/nrd1440

No abstract available

Publication types

Review

MeSH terms

Adrenergic beta-Antagonists / therapeutic use
Animals
Calcium / metabolism*
Calcium Signaling / drug effects
Heart Failure / drug therapy*
Heart Failure / metabolism
Heart Failure / physiopathology
Humans
Myocardial Contraction / drug effects*
Myocardium / metabolism*
Ryanodine Receptor Calcium Release Channel / metabolism*
Sarcoplasmic Reticulum / metabolism
Thiazepines / therapeutic use

Substances

Adrenergic beta-Antagonists
Ryanodine Receptor Calcium Release Channel
Thiazepines
K201 compound
Calcium