Abstract
To facilitate a rapid response to environmental change, cells use scaffolding - or adaptor - proteins to recruit key components of their signal-transduction machinery to specific subcellular locations. Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals.
MeSH terms
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ADP-Ribosylation Factors / physiology
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Actins / physiology
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Amino Acid Motifs
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Animals
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Cell Adhesion / physiology*
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Cytoskeletal Proteins / chemistry
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Cytoskeletal Proteins / physiology*
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Cytoskeleton / physiology
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Growth Substances / physiology
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Humans
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Integrins / physiology
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Models, Biological
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Paxillin
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Phosphoproteins / chemistry
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Phosphoproteins / physiology*
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Phosphorylation
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Protein Structure, Tertiary
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Signal Transduction
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rho GTP-Binding Proteins / physiology
Substances
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Actins
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Cytoskeletal Proteins
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Growth Substances
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Integrins
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PXN protein, human
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Paxillin
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Phosphoproteins
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ADP-Ribosylation Factors
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rho GTP-Binding Proteins