[go: up one dir, main page]
More Web Proxy on the site http://driver.im/ Skip to main content
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1999 Aug;65(2):302–307. doi: 10.1086/302520

Genes that regulate eosinophilic inflammation.

D H Broide 1, H Hoffman 1, P Sriramarao 1
PMCID: PMC1377928  PMID: 10417272

Full Text

The Full Text of this article is available as a PDF (279.0 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abraham W. M., Sielczak M. W., Ahmed A., Cortes A., Lauredo I. T., Kim J., Pepinsky B., Benjamin C. D., Leone D. R., Lobb R. R. Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep. J Clin Invest. 1994 Feb;93(2):776–787. doi: 10.1172/JCI117032. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baranger L., Szapiro N., Gardais J., Hillion J., Derre J., Francois S., Blanchet O., Boasson M., Berger R. Translocation t(5;12)(q31-q33;p12-p13): a non-random translocation associated with a myeloid disorder with eosinophilia. Br J Haematol. 1994 Oct;88(2):343–347. doi: 10.1111/j.1365-2141.1994.tb05029.x. [DOI] [PubMed] [Google Scholar]
  3. Broide D. H., Gleich G. J., Cuomo A. J., Coburn D. A., Federman E. C., Schwartz L. B., Wasserman S. I. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J Allergy Clin Immunol. 1991 Oct;88(4):637–648. doi: 10.1016/0091-6749(91)90158-k. [DOI] [PubMed] [Google Scholar]
  4. Broide D. H., Humber D., Sullivan S., Sriramarao P. Inhibition of eosinophil rolling and recruitment in P-selectin- and intracellular adhesion molecule-1-deficient mice. Blood. 1998 Apr 15;91(8):2847–2856. [PubMed] [Google Scholar]
  5. Broide D. H., Paine M. M., Firestein G. S. Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest. 1992 Oct;90(4):1414–1424. doi: 10.1172/JCI116008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Broide D., Schwarze J., Tighe H., Gifford T., Nguyen M. D., Malek S., Van Uden J., Martin-Orozco E., Gelfand E. W., Raz E. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J Immunol. 1998 Dec 15;161(12):7054–7062. [PubMed] [Google Scholar]
  7. Foster P. S., Hogan S. P., Ramsay A. J., Matthaei K. I., Young I. G. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med. 1996 Jan 1;183(1):195–201. doi: 10.1084/jem.183.1.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gonzalo J. A., Lloyd C. M., Wen D., Albar J. P., Wells T. N., Proudfoot A., Martinez-A C., Dorf M., Bjerke T., Coyle A. J. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J Exp Med. 1998 Jul 6;188(1):157–167. doi: 10.1084/jem.188.1.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Grayson M. H., Van der Vieren M., Sterbinsky S. A., Michael Gallatin W., Hoffman P. A., Staunton D. E., Bochner B. S. alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1). J Exp Med. 1998 Dec 7;188(11):2187–2191. doi: 10.1084/jem.188.11.2187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Heath H., Qin S., Rao P., Wu L., LaRosa G., Kassam N., Ponath P. D., Mackay C. R. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest. 1997 Jan 15;99(2):178–184. doi: 10.1172/JCI119145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Henderson W. R., Jr, Chi E. Y., Albert R. K., Chu S. J., Lamm W. J., Rochon Y., Jonas M., Christie P. E., Harlan J. M. Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J Clin Invest. 1997 Dec 15;100(12):3083–3092. doi: 10.1172/JCI119863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hsu C. H., Chua K. Y., Tao M. H., Lai Y. L., Wu H. D., Huang S. K., Hsieh K. H. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nat Med. 1996 May;2(5):540–544. doi: 10.1038/nm0596-540. [DOI] [PubMed] [Google Scholar]
  13. Kitaura M., Nakajima T., Imai T., Harada S., Combadiere C., Tiffany H. L., Murphy P. M., Yoshie O. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J Biol Chem. 1996 Mar 29;271(13):7725–7730. doi: 10.1074/jbc.271.13.7725. [DOI] [PubMed] [Google Scholar]
  14. Kitayama J., Mackay C. R., Ponath P. D., Springer T. A. The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow. J Clin Invest. 1998 May 1;101(9):2017–2024. doi: 10.1172/JCI2688. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kline J. N., Waldschmidt T. J., Businga T. R., Lemish J. E., Weinstock J. V., Thorne P. S., Krieg A. M. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol. 1998 Mar 15;160(6):2555–2559. [PubMed] [Google Scholar]
  16. Martinez F. D., Solomon S., Holberg C. J., Graves P. E., Baldini M., Erickson R. P. Linkage of circulating eosinophils to markers on chromosome 5q. Am J Respir Crit Care Med. 1998 Dec;158(6):1739–1744. doi: 10.1164/ajrccm.158.6.9712040. [DOI] [PubMed] [Google Scholar]
  17. Nakajima H., Sano H., Nishimura T., Yoshida S., Iwamoto I. Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J Exp Med. 1994 Apr 1;179(4):1145–1154. doi: 10.1084/jem.179.4.1145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Palframan R. T., Collins P. D., Severs N. J., Rothery S., Williams T. J., Rankin S. M. Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. J Exp Med. 1998 Nov 2;188(9):1621–1632. doi: 10.1084/jem.188.9.1621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Phillips M. L., Schwartz B. R., Etzioni A., Bayer R., Ochs H. D., Paulson J. C., Harlan J. M. Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2. J Clin Invest. 1995 Dec;96(6):2898–2906. doi: 10.1172/JCI118361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Ponath P. D., Qin S., Post T. W., Wang J., Wu L., Gerard N. P., Newman W., Gerard C., Mackay C. R. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med. 1996 Jun 1;183(6):2437–2448. doi: 10.1084/jem.183.6.2437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rioux J. D., Stone V. A., Daly M. J., Cargill M., Green T., Nguyen H., Nutman T., Zimmerman P. A., Tucker M. A., Hudson T. Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33. Am J Hum Genet. 1998 Oct;63(4):1086–1094. doi: 10.1086/302053. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Rothenberg M. E. Eosinophilia. N Engl J Med. 1998 May 28;338(22):1592–1600. doi: 10.1056/NEJM199805283382206. [DOI] [PubMed] [Google Scholar]
  23. Rothenberg M. E., MacLean J. A., Pearlman E., Luster A. D., Leder P. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med. 1997 Feb 17;185(4):785–790. doi: 10.1084/jem.185.4.785. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Ruuls S. R., Sedgwick J. D. Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and animal models. Am J Hum Genet. 1999 Aug;65(2):294–301. doi: 10.1086/302517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Sriramarao P., Norton C. R., Borgstrom P., DiScipio R. G., Wolitzky B. A., Broide D. H. E-selectin preferentially supports neutrophil but not eosinophil rolling under conditions of flow in vitro and in vivo. J Immunol. 1996 Nov 15;157(10):4672–4680. [PubMed] [Google Scholar]
  26. Sriramarao P., von Andrian U. H., Butcher E. C., Bourdon M. A., Broide D. H. L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo. J Immunol. 1994 Nov 1;153(9):4238–4246. [PubMed] [Google Scholar]
  27. Sung K. L., Li Y., Elices M., Gang J., Sriramarao P., Broide D. H. Granulocyte-macrophage colony-stimulating factor regulates the functional adhesive state of very late antigen-4 expressed by eosinophils. J Immunol. 1997 Jan 15;158(2):919–927. [PubMed] [Google Scholar]
  28. Weller P. F. Human eosinophils. J Allergy Clin Immunol. 1997 Sep;100(3):283–287. doi: 10.1016/s0091-6749(97)70237-9. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES