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Lupus erythematosus

MedGen UID:
98043
•Concept ID:
C0409974
•
Disease or Syndrome
Synonyms: LE - Lupus erythematosus; Lupus; lupus; Lupus Erythematosus; lupus erythematosus
SNOMED CT: Lupus erythematosus (200936003); LE - Lupus erythematosus (200936003); Lupus (200936003)
 
Monarch Initiative: MONDO:0004670

Definition

An autoimmune, connective tissue chronic inflammatory disorder affecting the skin, joints, kidneys, lungs, heart, and the peripheral blood cells. It is more commonly seen in women than men. Variants include discoid and systemic lupus erythematosus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLupus erythematosus

Professional guidelines

PubMed

Diagnosis and Treatment of Acute Myocarditis: A Review.
Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
Lupus nephritis: new progress in diagnosis and treatment.
Yu C, Li P, Dang X, Zhang X, Mao Y, Chen X
J Autoimmun 2022 Oct;132:102871. Epub 2022 Aug 20 doi: 10.1016/j.jaut.2022.102871. PMID: 35999111
Systemic lupus erythematosus: Diagnosis and clinical management.
Fava A, Petri M
J Autoimmun 2019 Jan;96:1-13. Epub 2018 Nov 16 doi: 10.1016/j.jaut.2018.11.001. PMID: 30448290Free PMC Article

Recent clinical studies

Etiology

Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets.
Crow MK
Ann Rheum Dis 2023 Aug;82(8):999-1014. Epub 2023 Feb 15 doi: 10.1136/ard-2022-223741. PMID: 36792346
Systemic Lupus Erythematosus: New Diagnostic and Therapeutic Approaches.
Lazar S, Kahlenberg JM
Annu Rev Med 2023 Jan 27;74:339-352. Epub 2022 Jul 8 doi: 10.1146/annurev-med-043021-032611. PMID: 35804480
Systemic Lupus Erythematosus in Children and Young People.
Charras A, Smith E, Hedrich CM
Curr Rheumatol Rep 2021 Feb 10;23(3):20. doi: 10.1007/s11926-021-00985-0. PMID: 33569643Free PMC Article
New classification criteria for systemic lupus erythematosus.
Aringer M, Petri M
Curr Opin Rheumatol 2020 Nov;32(6):590-596. doi: 10.1097/BOR.0000000000000740. PMID: 32925250Free PMC Article
Systemic Lupus Erythematosus.
Kiriakidou M, Ching CL
Ann Intern Med 2020 Jun 2;172(11):ITC81-ITC96. doi: 10.7326/AITC202006020. PMID: 32479157

Diagnosis

Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspects.
Vale ECSD, Garcia LC
An Bras Dermatol 2023 May-Jun;98(3):355-372. Epub 2023 Mar 1 doi: 10.1016/j.abd.2022.09.005. PMID: 36868923Free PMC Article
One year in review 2022: systemic lupus erythematosus.
Zucchi D, Elefante E, Schilirò D, Signorini V, Trentin F, Bortoluzzi A, Tani C
Clin Exp Rheumatol 2022 Jan;40(1):4-14. Epub 2022 Jan 28 doi: 10.55563/clinexprheumatol/nolysy. PMID: 35088691
Systemic lupus erythematosus 2020.
Narváez J
Med Clin (Barc) 2020 Dec 11;155(11):494-501. Epub 2020 Jun 23 doi: 10.1016/j.medcli.2020.05.009. PMID: 32586673
Systemic Lupus Erythematosus.
Kiriakidou M, Ching CL
Ann Intern Med 2020 Jun 2;172(11):ITC81-ITC96. doi: 10.7326/AITC202006020. PMID: 32479157
Editorial: Systemic Lupus Erythematosus and Antiphospholipid Syndrome.
Meroni PL, Tsokos GC
Front Immunol 2019;10:199. Epub 2019 Feb 25 doi: 10.3389/fimmu.2019.00199. PMID: 30858846Free PMC Article

Therapy

Litifilimab (BIIB059), a promising investigational drug for cutaneous lupus erythematosus.
Cho SK, Vazquez T, Werth VP
Expert Opin Investig Drugs 2023 May;32(5):345-353. Epub 2023 May 15 doi: 10.1080/13543784.2023.2212154. PMID: 37148249
An Update on the Management of Childhood-Onset Systemic Lupus Erythematosus.
Trindade VC, Carneiro-Sampaio M, Bonfa E, Silva CA
Paediatr Drugs 2021 Jul;23(4):331-347. Epub 2021 Jul 10 doi: 10.1007/s40272-021-00457-z. PMID: 34244988Free PMC Article
Management of inflammatory neurologic and psychiatric manifestations of systemic lupus erythematosus: A systematic review.
Papachristos DA, Oon S, Hanly JG, Nikpour M
Semin Arthritis Rheum 2021 Feb;51(1):49-71. Epub 2020 Dec 17 doi: 10.1016/j.semarthrit.2020.12.004. PMID: 33360230
Non-pharmacologic therapies for systemic lupus erythematosus.
Fangtham M, Kasturi S, Bannuru RR, Nash JL, Wang C
Lupus 2019 May;28(6):703-712. Epub 2019 Apr 8 doi: 10.1177/0961203319841435. PMID: 30961418Free PMC Article
Management of Neuropsychiatric Systemic Lupus Erythematosus: Current Approaches and Future Perspectives.
Magro-Checa C, Zirkzee EJ, Huizinga TW, Steup-Beekman GM
Drugs 2016 Mar;76(4):459-83. doi: 10.1007/s40265-015-0534-3. PMID: 26809245Free PMC Article

Prognosis

Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yao X, Huang Y, Lu Q
Ann Rheum Dis 2023 Mar;82(3):351-356. Epub 2022 Oct 14 doi: 10.1136/ard-2022-223035. PMID: 36241363Free PMC Article
Cardiac Manifestations of Systemic Lupus Erythematous: An Overview of the Incidence, Risk Factors, Diagnostic Criteria, Pathophysiology and Treatment Options.
Zagelbaum Ward NK, Linares-Koloffon C, Posligua A, Gandrabur L, Kim WY, Sperber K, Wasserman A, Ash J
Cardiol Rev 2022 Jan-Feb 01;30(1):38-43. doi: 10.1097/CRD.0000000000000358. PMID: 32991394
Systemic lupus erythematosus, lupus nephritis and end-stage renal disease: a pragmatic review mapping disease severity and progression.
Mahajan A, Amelio J, Gairy K, Kaur G, Levy RA, Roth D, Bass D
Lupus 2020 Aug;29(9):1011-1020. Epub 2020 Jun 22 doi: 10.1177/0961203320932219. PMID: 32571142Free PMC Article
The global burden of SLE: prevalence, health disparities and socioeconomic impact.
Carter EE, Barr SG, Clarke AE
Nat Rev Rheumatol 2016 Oct;12(10):605-20. Epub 2016 Aug 25 doi: 10.1038/nrrheum.2016.137. PMID: 27558659
Systemic lupus erythematosus disease activity index 2000.
Gladman DD, Ibañez D, Urowitz MB
J Rheumatol 2002 Feb;29(2):288-91. PMID: 11838846

Clinical prediction guides

Extracellular Vesicles in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Functions and Applications.
Zhang B, Zhao M, Lu Q
Front Immunol 2020;11:575712. Epub 2021 Jan 14 doi: 10.3389/fimmu.2020.575712. PMID: 33519800Free PMC Article
Systemic lupus erythematosus, lupus nephritis and end-stage renal disease: a pragmatic review mapping disease severity and progression.
Mahajan A, Amelio J, Gairy K, Kaur G, Levy RA, Roth D, Bass D
Lupus 2020 Aug;29(9):1011-1020. Epub 2020 Jun 22 doi: 10.1177/0961203320932219. PMID: 32571142Free PMC Article
Clinical application of protein biomarkers in lupus erythematosus and lupus nephritis.
Qi S, Chen Q, Xu D, Xie N, Dai Y
Lupus 2018 Sep;27(10):1582-1590. Epub 2018 May 3 doi: 10.1177/0961203318773643. PMID: 29720035
Advances in the diagnosis and classification of systemic lupus erythematosus.
Larosa M, Iaccarino L, Gatto M, Punzi L, Doria A
Expert Rev Clin Immunol 2016 Dec;12(12):1309-1320. Epub 2016 Jul 8 doi: 10.1080/1744666X.2016.1206470. PMID: 27362864
BILAG 2004. Development and initial validation of an updated version of the British Isles Lupus Assessment Group's disease activity index for patients with systemic lupus erythematosus.
Isenberg DA, Rahman A, Allen E, Farewell V, Akil M, Bruce IN, D'Cruz D, Griffiths B, Khamashta M, Maddison P, McHugh N, Snaith M, Teh LS, Yee CS, Zoma A, Gordon C
Rheumatology (Oxford) 2005 Jul;44(7):902-6. Epub 2005 Apr 6 doi: 10.1093/rheumatology/keh624. PMID: 15814577

Recent systematic reviews

Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yao X, Huang Y, Lu Q
Ann Rheum Dis 2023 Mar;82(3):351-356. Epub 2022 Oct 14 doi: 10.1136/ard-2022-223035. PMID: 36241363Free PMC Article
Pregnancy in patients with systemic lupus erythematosus: a systematic review.
Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
Oral Manifestations of Systemic Lupus Erythematosus: A Systematic Review.
García-Ríos P, Pecci-Lloret MP, Oñate-Sánchez RE
Int J Environ Res Public Health 2022 Sep 21;19(19) doi: 10.3390/ijerph191911910. PMID: 36231212Free PMC Article
Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention.
Jiao H, Acar G, Robinson GA, Ciurtin C, Jury EC, Kalea AZ
Int J Environ Res Public Health 2022 Sep 20;19(19) doi: 10.3390/ijerph191911895. PMID: 36231195Free PMC Article
EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome.
Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat-Chalumeau N, Doria A, Fischer-Betz R, Forger F, Moraes-Fontes MF, Khamashta M, King J, Lojacono A, Marchiori F, Meroni PL, Mosca M, Motta M, Ostensen M, Pamfil C, Raio L, Schneider M, Svenungsson E, Tektonidou M, Yavuz S, Boumpas D, Tincani A
Ann Rheum Dis 2017 Mar;76(3):476-485. Epub 2016 Jul 25 doi: 10.1136/annrheumdis-2016-209770. PMID: 27457513Free PMC Article

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