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Allergy, Milk

MedGen UID:
86965
•Concept ID:
C0079840
•
Pathologic Function
Synonyms: Hypersensitivity, Milk; Milk Allergies; Milk Allergy; Milk Hypersensitivities; Milk Hypersensitivity

Definition

Allergic reaction to milk (usually cow''s milk) or milk products. MILK HYPERSENSITIVITY should be differentiated from LACTOSE INTOLERANCE, an intolerance to milk as a result of congenital deficiency of lactase. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAllergy, Milk

Professional guidelines

PubMed

Cow's Milk Protein Allergy in Term and Preterm Infants: Clinical Manifestations, Immunologic Pathophysiology, and Management Strategies.
Burris AD, Burris J, Järvinen KM
Neoreviews 2020 Dec;21(12):e795-e808. doi: 10.1542/neo.21-12-e795. PMID: 33262206
Food Allergy Prevention and Treatment by Targeted Nutrition.
Heine RG
Ann Nutr Metab 2018;72 Suppl 3:33-45. Epub 2018 Apr 9 doi: 10.1159/000487380. PMID: 29631274
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment.
Sicherer SH, Sampson HA
J Allergy Clin Immunol 2014 Feb;133(2):291-307; quiz 308. Epub 2013 Dec 31 doi: 10.1016/j.jaci.2013.11.020. PMID: 24388012

Recent clinical studies

Etiology

Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT.
Bradshaw LE, Wyatt LA, Brown SJ, Haines RH, Montgomery AA, Perkin MR, Sach TH, Lawton S, Flohr C, Ridd MJ, Chalmers JR, Brooks J, Swinden R, Mitchell EJ, Tarr S, Jay N, Thomas KS, Allen H, Cork MJ, Kelleher MM, Simpson EL, Lartey ST, Davies-Jones S, Boyle RJ, Williams HC
Health Technol Assess 2024 Jul;28(29):1-116. doi: 10.3310/RHDN9613. PMID: 39021147Free PMC Article
Missed Diagnosis of Anaphylaxis in Patients With Pediatric Urticaria in the Emergency Department.
Jung WS, Kim SH, Lee H
Pediatr Emerg Care 2021 Apr 1;37(4):199-203. doi: 10.1097/PEC.0000000000001617. PMID: 30281553
The natural history of milk allergy in an observational cohort.
Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA
J Allergy Clin Immunol 2013 Mar;131(3):805-12. Epub 2012 Dec 28 doi: 10.1016/j.jaci.2012.10.060. PMID: 23273958Free PMC Article
Therapeutic modalities for cow's milk allergy.
Seidman EG, Singer S
Ann Allergy Asthma Immunol 2003 Jun;90(6 Suppl 3):104-11. doi: 10.1016/s1081-1206(10)61670-5. PMID: 12839123
Cow's milk allergy in the first year of life. An Italian Collaborative Study.
Acta Paediatr Scand Suppl 1988;348:1-14. PMID: 3071078

Diagnosis

Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT.
Bradshaw LE, Wyatt LA, Brown SJ, Haines RH, Montgomery AA, Perkin MR, Sach TH, Lawton S, Flohr C, Ridd MJ, Chalmers JR, Brooks J, Swinden R, Mitchell EJ, Tarr S, Jay N, Thomas KS, Allen H, Cork MJ, Kelleher MM, Simpson EL, Lartey ST, Davies-Jones S, Boyle RJ, Williams HC
Health Technol Assess 2024 Jul;28(29):1-116. doi: 10.3310/RHDN9613. PMID: 39021147Free PMC Article
Missed Diagnosis of Anaphylaxis in Patients With Pediatric Urticaria in the Emergency Department.
Jung WS, Kim SH, Lee H
Pediatr Emerg Care 2021 Apr 1;37(4):199-203. doi: 10.1097/PEC.0000000000001617. PMID: 30281553
The natural history of milk allergy in an observational cohort.
Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA
J Allergy Clin Immunol 2013 Mar;131(3):805-12. Epub 2012 Dec 28 doi: 10.1016/j.jaci.2012.10.060. PMID: 23273958Free PMC Article
Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age.
Bezrodnik L, Raccio AC, Canil LM, Rey MA, Carabajal PC, Fossati CA, Docena GH
Immunology 2007 Sep;122(1):140-6. Epub 2007 May 11 doi: 10.1111/j.1365-2567.2007.02628.x. PMID: 17498216Free PMC Article
Food hypersensitivity allergy or malabsorption.
Waickman FJ
Laryngoscope 1977 May;87(5 Pt 1):661-4. doi: 10.1002/lary.5540870502. PMID: 576724

Therapy

Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT.
Bradshaw LE, Wyatt LA, Brown SJ, Haines RH, Montgomery AA, Perkin MR, Sach TH, Lawton S, Flohr C, Ridd MJ, Chalmers JR, Brooks J, Swinden R, Mitchell EJ, Tarr S, Jay N, Thomas KS, Allen H, Cork MJ, Kelleher MM, Simpson EL, Lartey ST, Davies-Jones S, Boyle RJ, Williams HC
Health Technol Assess 2024 Jul;28(29):1-116. doi: 10.3310/RHDN9613. PMID: 39021147Free PMC Article
The natural history of milk allergy in an observational cohort.
Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA
J Allergy Clin Immunol 2013 Mar;131(3):805-12. Epub 2012 Dec 28 doi: 10.1016/j.jaci.2012.10.060. PMID: 23273958Free PMC Article
Therapeutic modalities for cow's milk allergy.
Seidman EG, Singer S
Ann Allergy Asthma Immunol 2003 Jun;90(6 Suppl 3):104-11. doi: 10.1016/s1081-1206(10)61670-5. PMID: 12839123
Cow's milk allergy in the first year of life. An Italian Collaborative Study.
Acta Paediatr Scand Suppl 1988;348:1-14. PMID: 3071078

Prognosis

The natural history of milk allergy in an observational cohort.
Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA
J Allergy Clin Immunol 2013 Mar;131(3):805-12. Epub 2012 Dec 28 doi: 10.1016/j.jaci.2012.10.060. PMID: 23273958Free PMC Article

Clinical prediction guides

Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT.
Bradshaw LE, Wyatt LA, Brown SJ, Haines RH, Montgomery AA, Perkin MR, Sach TH, Lawton S, Flohr C, Ridd MJ, Chalmers JR, Brooks J, Swinden R, Mitchell EJ, Tarr S, Jay N, Thomas KS, Allen H, Cork MJ, Kelleher MM, Simpson EL, Lartey ST, Davies-Jones S, Boyle RJ, Williams HC
Health Technol Assess 2024 Jul;28(29):1-116. doi: 10.3310/RHDN9613. PMID: 39021147Free PMC Article
The natural history of milk allergy in an observational cohort.
Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, Henning AK, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA
J Allergy Clin Immunol 2013 Mar;131(3):805-12. Epub 2012 Dec 28 doi: 10.1016/j.jaci.2012.10.060. PMID: 23273958Free PMC Article

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