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Increased body mass index

MedGen UID:
472957
Concept ID:
C0231254
Finding
Synonym: Increased BMI
SNOMED CT: Body mass index above normal parameters (48499001); Increased body mass index (48499001)
 
HPO: HP:0031418

Definition

Abnormally increased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of overweight compared to averages. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased body mass index

Conditions with this feature

X-linked intellectual disability-short stature-overweight syndrome
MedGen UID:
901885
Concept ID:
C0796218
Disease or Syndrome
Kumar-type X-linked syndromic intellectual developmental disorder (MRXSK) is an X-linked recessive disorder that shows phenotypic variability and multisystem involvement apparent from birth or early infancy. Most affected individuals are male, although 1 severely affected girl with a de novo THOC2 mutation has been reported. At the severe end of the spectrum, affected individuals have hypotonia, neonatal difficulties, failure to thrive with poor overall growth, feeding difficulties, respiratory insufficiency, visual impairment, profoundly impaired intellectual development with poor or absent speech, and motor abnormalities, such as inability to walk and hyperkinetic movements. Less severely affected individuals have mildly to moderately impaired intellectual development and speech delay. Additional features include behavioral abnormalities, hearing or visual defects, seizures, dysmorphic facial features, and brain imaging abnormalities (Kumar et al., 2015; Kumar et al., 2018; Kumar et al., 2020).
Congenital nongoitrous hypothyroidism 6
MedGen UID:
482447
Concept ID:
C3280817
Disease or Syndrome
Any hypothyroidism, congenital, nongoitrous in which the cause of the disease is a mutation in the THRA gene.

Professional guidelines

PubMed

Uddandrao VVS, Brahma Naidu P, Chandrasekaran P, Saravanan G
Int J Obes (Lond) 2024 Feb;48(2):147-165. Epub 2023 Nov 14 doi: 10.1038/s41366-023-01411-4. PMID: 37963998
Lepley T, Schwager Z, Khalid Z
Prim Care Companion CNS Disord 2022 Feb 17;24(1) doi: 10.4088/PCC.21r03062. PMID: 35180815
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037

Recent clinical studies

Etiology

Litwin M, Kułaga Z
Pediatr Nephrol 2021 Apr;36(4):825-837. Epub 2020 May 9 doi: 10.1007/s00467-020-04579-3. PMID: 32388582Free PMC Article
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Trojian T, Tucker AK
Am Fam Physician 2019 Jun 15;99(12):744-750. PMID: 31194492
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037
Taheri S, Lin L, Austin D, Young T, Mignot E
PLoS Med 2004 Dec;1(3):e62. Epub 2004 Dec 7 doi: 10.1371/journal.pmed.0010062. PMID: 15602591Free PMC Article

Diagnosis

Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, Daida H, Ishijima M, Kaneko K, Nojiri S, Kawamori R, Watada H
Clin Nutr 2022 May;41(5):1046-1051. Epub 2022 Mar 16 doi: 10.1016/j.clnu.2022.03.017. PMID: 35390728
Ribeiro LM, Sasaki LMP, Silva AA, Souza ES, Oliveira Lyrio A, C M G Figueiredo A, Gottems LBD
Eur J Obstet Gynecol Reprod Biol 2022 Apr;271:117-127. Epub 2022 Jan 31 doi: 10.1016/j.ejogrb.2022.01.019. PMID: 35183001
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Trojian T, Tucker AK
Am Fam Physician 2019 Jun 15;99(12):744-750. PMID: 31194492
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037

Therapy

Wang J, Hu Y, Zeng J, Li Q, He L, Hao W, Song X, Yan S, Lv C
Int J Public Health 2023;68:1605548. Epub 2023 May 2 doi: 10.3389/ijph.2023.1605548. PMID: 37205044Free PMC Article
Ribeiro LM, Sasaki LMP, Silva AA, Souza ES, Oliveira Lyrio A, C M G Figueiredo A, Gottems LBD
Eur J Obstet Gynecol Reprod Biol 2022 Apr;271:117-127. Epub 2022 Jan 31 doi: 10.1016/j.ejogrb.2022.01.019. PMID: 35183001
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037
Li D
J Agric Food Chem 2011 Feb 9;59(3):777-84. Epub 2011 Jan 4 doi: 10.1021/jf103846u. PMID: 21204526
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

Prognosis

Sheu A, Greenfield JR, White CP, Center JR
Trends Endocrinol Metab 2023 Jan;34(1):34-48. Epub 2022 Nov 23 doi: 10.1016/j.tem.2022.11.003. PMID: 36435679
Mili N, Paschou SA, Goulis DG, Dimopoulos MA, Lambrinoudaki I, Psaltopoulou T
Endocrine 2021 Dec;74(3):478-497. Epub 2021 Oct 8 doi: 10.1007/s12020-021-02884-x. PMID: 34625915
Walsh KM
Handb Clin Neurol 2020;169:3-15. doi: 10.1016/B978-0-12-804280-9.00001-9. PMID: 32553297
Taheri S, Lin L, Austin D, Young T, Mignot E
PLoS Med 2004 Dec;1(3):e62. Epub 2004 Dec 7 doi: 10.1371/journal.pmed.0010062. PMID: 15602591Free PMC Article
Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, Kannel WB, Vasan RS
N Engl J Med 2002 Aug 1;347(5):305-13. doi: 10.1056/NEJMoa020245. PMID: 12151467

Clinical prediction guides

Litwin M, Kułaga Z
Pediatr Nephrol 2021 Apr;36(4):825-837. Epub 2020 May 9 doi: 10.1007/s00467-020-04579-3. PMID: 32388582Free PMC Article
Went M, Cornish AJ, Law PJ, Kinnersley B, van Duin M, Weinhold N, Försti A, Hansson M, Sonneveld P, Goldschmidt H, Morgan GJ, Hemminki K, Nilsson B, Kaiser M, Houlston RS
Blood Adv 2020 May 26;4(10):2172-2179. doi: 10.1182/bloodadvances.2020001502. PMID: 32433745Free PMC Article
Antonopoulos AS, Tousoulis D
Cardiovasc Res 2017 Jul 1;113(9):1074-1086. doi: 10.1093/cvr/cvx106. PMID: 28549096
Barton JC, Acton RT
J Diabetes Res 2017;2017:9826930. Epub 2017 Feb 26 doi: 10.1155/2017/9826930. PMID: 28331855Free PMC Article
Taheri S, Lin L, Austin D, Young T, Mignot E
PLoS Med 2004 Dec;1(3):e62. Epub 2004 Dec 7 doi: 10.1371/journal.pmed.0010062. PMID: 15602591Free PMC Article

Recent systematic reviews

Ribeiro LM, Sasaki LMP, Silva AA, Souza ES, Oliveira Lyrio A, C M G Figueiredo A, Gottems LBD
Eur J Obstet Gynecol Reprod Biol 2022 Apr;271:117-127. Epub 2022 Jan 31 doi: 10.1016/j.ejogrb.2022.01.019. PMID: 35183001
Amiri S, Behnezhad S
Neuropsychiatr 2019 Jun;33(2):72-89. Epub 2019 Feb 18 doi: 10.1007/s40211-019-0302-9. PMID: 30778841
Sommer A, Twig G
Curr Diab Rep 2018 Aug 30;18(10):91. doi: 10.1007/s11892-018-1062-9. PMID: 30167798
Tan W, Gao M, Liu N, Zhang G, Xu T, Cui W
Nutrients 2015 Sep 25;7(10):8321-34. doi: 10.3390/nu7105387. PMID: 26426043Free PMC Article
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

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