[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Warning: The NCBI web site requires JavaScript to function. more...

U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Necrobiosis lipoidica

MedGen UID:
45021
Concept ID:
C0027538
Disease or Syndrome
Synonym: Necrobiosis Lipoidica
SNOMED CT: NLD - Necrobiosis lipoidica (9418005); Necrobiosis lipoidica (9418005)
 
Monarch Initiative: MONDO:0006583
Orphanet: ORPHA542592

Definition

A rare skin disease characterized by enlarging, annular plaques with red-brown edges and atrophic, yellow-brown, telangiectatic centers. The lesions are commonly asymptomatic, but affected skin areas may be fragile, and painful ulcerations develop in many cases. In rare cases, development of squamous cell carcinoma within longstanding lesions has been reported. The lower legs, especially the shins, are the most frequently involved site. The condition is often associated with diabetes mellitus. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecrobiosis lipoidica

Professional guidelines

PubMed

Nihal A, Caplan AS, Rosenbach M, Damsky W, Mangold AR, Shields BE
Int J Dermatol 2023 Dec;62(12):1529-1537. Epub 2023 Sep 29 doi: 10.1111/ijd.16856. PMID: 37772666
Gibson RS, Salian P, Beckles A, Stavert R, Tahan S, Kimball AB, Porter ML
Int J Dermatol 2023 Sep;62(9):1198-1201. Epub 2023 Jul 1 doi: 10.1111/ijd.16780. PMID: 37392065
López Sanz P, Faura Berruga C, Guerrero Ramírez C, Manso Córdoba S, Alfaro Martínez ME, García Vázquez A
Photodermatol Photoimmunol Photomed 2023 May;39(3):294-295. Epub 2022 Aug 31 doi: 10.1111/phpp.12831. PMID: 35996345

Recent clinical studies

Etiology

Kök GF, Türsen Ü
Adv Exp Med Biol 2022;1367:349-368. doi: 10.1007/978-3-030-92616-8_13. PMID: 35286702
Passanisi S, Salzano G, Lombardo F
Curr Diabetes Rev 2022;18(4):e030921196145. doi: 10.2174/1573399817666210903153837. PMID: 34477525
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
Frew JW, Murrell DF, Haber RM
Int J Dermatol 2015 Oct;54(10):1109-23. Epub 2015 Jul 30 doi: 10.1111/ijd.12945. PMID: 26227781
Grillo E, Rodriguez-Muñoz D, González-Garcia A, Jaén P
Aust Fam Physician 2014 Mar;43(3):129-30. PMID: 24600675

Diagnosis

Harvey JA, Severson KJ, Brumfiel CM, Patel MH, Butterfield RJ, Nelson SA, Sekulic A, Pittelkow MR, Mangold AR
J Am Acad Dermatol 2022 Jun;86(6):1428-1429. Epub 2021 Jun 18 doi: 10.1016/j.jaad.2021.06.848. PMID: 34153393
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
Wick MR
Semin Diagn Pathol 2017 May;34(3):261-272. Epub 2016 Dec 27 doi: 10.1053/j.semdp.2016.12.004. PMID: 28129926
Sibbald C, Reid S, Alavi A
Dermatol Clin 2015 Jul;33(3):343-60. doi: 10.1016/j.det.2015.03.003. PMID: 26143418
Boyd AS
Int J Dermatol 2007 Jun;46(6):557-63. doi: 10.1111/j.1365-4632.2007.03273.x. PMID: 17550551

Therapy

Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
Nascimento J, Machado S
Pediatr Int 2016 Feb;58(2):165-6. doi: 10.1111/ped.12872. PMID: 26865027
Sibbald C, Reid S, Alavi A
Dermatol Clin 2015 Jul;33(3):343-60. doi: 10.1016/j.det.2015.03.003. PMID: 26143418
Boyd AS
Int J Dermatol 2007 Jun;46(6):557-63. doi: 10.1111/j.1365-4632.2007.03273.x. PMID: 17550551
Ahmed I, Goldstein B
Clin Dermatol 2006 Jul-Aug;24(4):237-46. doi: 10.1016/j.clindermatol.2006.04.009. PMID: 16828404

Prognosis

Sanches MM, Roda Â, Pimenta R, Filipe PL, Freitas JP
Acta Med Port 2019 Jun 28;32(6):459-465. doi: 10.20344/amp.10738. PMID: 31292028
Sibbald C, Reid S, Alavi A
Dermatol Clin 2015 Jul;33(3):343-60. doi: 10.1016/j.det.2015.03.003. PMID: 26143418
Murphy-Chutorian B, Han G, Cohen SR
Endocrinol Metab Clin North Am 2013 Dec;42(4):869-98. doi: 10.1016/j.ecl.2013.07.004. PMID: 24286954
Ahmed I, Goldstein B
Clin Dermatol 2006 Jul-Aug;24(4):237-46. doi: 10.1016/j.clindermatol.2006.04.009. PMID: 16828404
Sibbald RG, Landolt SJ, Toth D
Endocrinol Metab Clin North Am 1996 Jun;25(2):463-72. doi: 10.1016/s0889-8529(05)70334-0. PMID: 8799710

Clinical prediction guides

Kuraitis D, Murina A
Cutis 2024 Jan;113(1):29-34. doi: 10.12788/cutis.0914. PMID: 38478947
Passanisi S, Salzano G, Lombardo F
Curr Diabetes Rev 2022;18(4):e030921196145. doi: 10.2174/1573399817666210903153837. PMID: 34477525
Berman HS, Shabihkhani M, Hogeling M
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754363. PMID: 34391328
Schmitt A, Volz A
J Dtsch Dermatol Ges 2019 May;17(5):518-533. doi: 10.1111/ddg.13848. PMID: 31115996
Borgia F, Vaccaro M, Cantavenera LG, Aragona E, Cannavò SP
Photodiagnosis Photodyn Ther 2014 Dec;11(4):516-8. Epub 2014 Aug 21 doi: 10.1016/j.pdpdt.2014.08.002. PMID: 25150669

Recent systematic reviews

Nihal A, Caplan AS, Rosenbach M, Damsky W, Mangold AR, Shields BE
Int J Dermatol 2023 Dec;62(12):1529-1537. Epub 2023 Sep 29 doi: 10.1111/ijd.16856. PMID: 37772666
Sood S, Heung M, Georgakopoulos JR, Mufti A, Prajapati VH, Yeung J
J Am Acad Dermatol 2023 Aug;89(2):357-359. Epub 2023 Mar 28 doi: 10.1016/j.jaad.2023.03.024. PMID: 36990321
Seivright JR, Villa NM, De DR, Hsiao JL, Shi VY
Dermatol Ther 2022 Feb;35(2):e15234. Epub 2021 Dec 8 doi: 10.1111/dth.15234. PMID: 34825744
Mistry BD, Alavi A, Ali S, Mistry N
Int J Dermatol 2017 Dec;56(12):1319-1327. Epub 2017 Jun 26 doi: 10.1111/ijd.13610. PMID: 28650076
Kroft EB, Berkhof NJ, van de Kerkhof PC, Gerritsen RM, de Jong EM
J Am Acad Dermatol 2008 Dec;59(6):1017-30. Epub 2008 Oct 2 doi: 10.1016/j.jaad.2008.07.042. PMID: 18835066

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...