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Anaphylaxis

MedGen UID:
1902
•Concept ID:
C0002792
•
Pathologic Function
Synonyms: Anaphylactic reaction; Generalized anaphylaxis; Systemic anaphylaxis
SNOMED CT: Generalized anaphylaxis (39579001); Systemic anaphylaxis (39579001); Anaphylaxis (39579001); Anaphylactic reaction (39579001)

Definition

An acute hypersensitive immune response that occurs from exposure to an allergen. It results from the release of histamine and histamine-like substances from mast cells, and can present with breathing difficulty due to narrowed airways, dizziness and hypotension, skin rash, weak pulse, nausea and vomiting. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaphylaxis

Professional guidelines

PubMed

Anaphylaxis: A 2023 practice parameter update.
Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Abrams EM, Bernstein JA, Chu DK, Horner CC, Rank MA, Stukus DR; Collaborators, Burrows AG, Cruickshank H; Workgroup Contributors, Golden DBK, Wang J, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Waserman S; Joint Task Force on Practice Parameters Reviewers, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Rank MA, Shaker MS, Stukus DR, Wang J
Ann Allergy Asthma Immunol 2024 Feb;132(2):124-176. Epub 2023 Dec 18 doi: 10.1016/j.anai.2023.09.015. PMID: 38108678
Anaphylaxis: Recognition and Management.
Pflipsen MC, Vega Colon KM
Am Fam Physician 2020 Sep 15;102(6):355-362. PMID: 32931210
Evaluation and Management of Penicillin Allergy: A Review.
Shenoy ES, Macy E, Rowe T, Blumenthal KG
JAMA 2019 Jan 15;321(2):188-199. doi: 10.1001/jama.2018.19283. PMID: 30644987

Recent clinical studies

Etiology

Anaphylaxis: Epidemiology and Differential Diagnosis.
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Overview of Allergy and Anaphylaxis.
Dribin TE, Motosue MS, Campbell RL
Emerg Med Clin North Am 2022 Feb;40(1):1-17. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.08.007. PMID: 34782082Free PMC Article
EAACI guidelines: Anaphylaxis (2021 update).
Muraro A, Worm M, Alviani C, Cardona V, DunnGalvin A, Garvey LH, Riggioni C, de Silva D, Angier E, Arasi S, Bellou A, Beyer K, Bijlhout D, Bilò MB, Bindslev-Jensen C, Brockow K, Fernandez-Rivas M, Halken S, Jensen B, Khaleva E, Michaelis LJ, Oude Elberink HNG, Regent L, Sanchez A, Vlieg-Boerstra BJ, Roberts G; European Academy of Allergy and Clinical Immunology, Food Allergy, Anaphylaxis Guidelines Group
Allergy 2022 Feb;77(2):357-377. Epub 2021 Sep 1 doi: 10.1111/all.15032. PMID: 34343358
Anaphylaxis.
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Anaphylaxis: Recognition and Management.
Pflipsen MC, Vega Colon KM
Am Fam Physician 2020 Sep 15;102(6):355-362. PMID: 32931210

Diagnosis

Management of Anaphylaxis.
Navalpakam A, Thanaputkaiporn N, Poowuttikul P
Immunol Allergy Clin North Am 2022 Feb;42(1):65-76. doi: 10.1016/j.iac.2021.09.005. PMID: 34823751
Anaphylaxis: Epidemiology and Differential Diagnosis.
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Overview of Allergy and Anaphylaxis.
Dribin TE, Motosue MS, Campbell RL
Emerg Med Clin North Am 2022 Feb;40(1):1-17. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.08.007. PMID: 34782082Free PMC Article
Anaphylaxis.
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Anaphylaxis: Recognition and Management.
Pflipsen MC, Vega Colon KM
Am Fam Physician 2020 Sep 15;102(6):355-362. PMID: 32931210

Therapy

Cow's Milk Protein Allergy.
Malik R, Kaul S
Indian J Pediatr 2024 May;91(5):499-506. Epub 2023 Oct 18 doi: 10.1007/s12098-023-04866-5. PMID: 37851326
Critical Care Management of the Patient With Anaphylaxis: A Concise Definitive Review.
Krishnaswamy G
Crit Care Med 2021 May 1;49(5):838-857. doi: 10.1097/CCM.0000000000004893. PMID: 33653974
Primary Prevention of Cow's Milk Sensitization and Food Allergy by Avoiding Supplementation With Cow's Milk Formula at Birth: A Randomized Clinical Trial.
Urashima M, Mezawa H, Okuyama M, Urashima T, Hirano D, Gocho N, Tachimoto H
JAMA Pediatr 2019 Dec 1;173(12):1137-1145. doi: 10.1001/jamapediatrics.2019.3544. PMID: 31633778Free PMC Article
Non surgical therapy for anal fissure.
Nelson RL, Thomas K, Morgan J, Jones A
Cochrane Database Syst Rev 2012 Feb 15;2012(2):CD003431. doi: 10.1002/14651858.CD003431.pub3. PMID: 22336789Free PMC Article
The safety and side effects of monoclonal antibodies.
Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJ
Nat Rev Drug Discov 2010 Apr;9(4):325-38. Epub 2010 Mar 22 doi: 10.1038/nrd3003. PMID: 20305665

Prognosis

Immunoglobulin E (IgE)-Mediated Food Allergy in Children: Epidemiology, Pathogenesis, Diagnosis, Prevention, and Management.
Barni S, Liccioli G, Sarti L, Giovannini M, Novembre E, Mori F
Medicina (Kaunas) 2020 Mar 4;56(3) doi: 10.3390/medicina56030111. PMID: 32143431Free PMC Article
Adverse drug reactions.
Patton K, Borshoff DC
Anaesthesia 2018 Jan;73 Suppl 1:76-84. doi: 10.1111/anae.14143. PMID: 29313907
Fatal Anaphylaxis: Mortality Rate and Risk Factors.
Turner PJ, Jerschow E, Umasunthar T, Lin R, Campbell DE, Boyle RJ
J Allergy Clin Immunol Pract 2017 Sep-Oct;5(5):1169-1178. doi: 10.1016/j.jaip.2017.06.031. PMID: 28888247Free PMC Article
Idiopathic systemic capillary leak syndrome (Clarkson disease).
Druey KM, Parikh SM
J Allergy Clin Immunol 2017 Sep;140(3):663-670. Epub 2016 Dec 22 doi: 10.1016/j.jaci.2016.10.042. PMID: 28012935Free PMC Article
Epidemiology of anaphylaxis.
Tejedor Alonso MA, Moro Moro M, Múgica García MV
Clin Exp Allergy 2015 Jun;45(6):1027-39. doi: 10.1111/cea.12418. PMID: 25495512

Clinical prediction guides

Anaphylaxis: Emergency Department Treatment.
McHugh K, Repanshek Z
Immunol Allergy Clin North Am 2023 Aug;43(3):453-466. doi: 10.1016/j.iac.2022.10.002. PMID: 37394252
Anaphylaxis: Epidemiology and Differential Diagnosis.
Motosue MS, Li JT, Campbell RL
Immunol Allergy Clin North Am 2022 Feb;42(1):13-25. doi: 10.1016/j.iac.2021.09.010. PMID: 34823743
Anaphylaxis: Emergency Department Treatment.
McHugh K, Repanshek Z
Emerg Med Clin North Am 2022 Feb;40(1):19-32. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.08.004. PMID: 34782088
Anaphylaxis.
Bilò MB, Martini M, Tontini C, Corsi A, Antonicelli L
Eur Ann Allergy Clin Immunol 2021 Jan;53(1):4-17. Epub 2021 Jan 7 doi: 10.23822/EurAnnACI.1764-1489.158. PMID: 32550734
Anaphylaxis: Recognition and Management.
Pflipsen MC, Vega Colon KM
Am Fam Physician 2020 Sep 15;102(6):355-362. PMID: 32931210

Recent systematic reviews

Omalizumab in IgE-Mediated Food Allergy: A Systematic Review and Meta-Analysis.
Zuberbier T, Wood RA, Bindslev-Jensen C, Fiocchi A, Chinthrajah RS, Worm M, Deschildre A, Fernandez-Rivas M, Santos AF, Jaumont X, Tassinari P
J Allergy Clin Immunol Pract 2023 Apr;11(4):1134-1146. Epub 2022 Dec 15 doi: 10.1016/j.jaip.2022.11.036. PMID: 36529441
Aetiology, Prevention and Management of Alveolar Osteitis-A Scoping Review.
Ghosh A, Aggarwal VR, Moore R
J Oral Rehabil 2022 Jan;49(1):103-113. Epub 2021 Oct 22 doi: 10.1111/joor.13268. PMID: 34625985
Diagnosing, managing and preventing anaphylaxis: Systematic review.
de Silva D, Singh C, Muraro A, Worm M, Alviani C, Cardona V, DunnGlvin A, Garvey LH, Riggioni C, Angier E, Arasi S, Bellou A, Beyer K, Bijlhout D, Bilo MB, Brockow K, Fernandez-Rivas M, Halken S, Jensen B, Khaleva E, Michaelis LJ, Oude Elberink H, Regent L, Sanchez A, Vlieg-Boerstra B, Roberts G; European Academy of Allergy and Clinical Immunology Food Allergy and Anaphylaxis Guidelines Group
Allergy 2021 May;76(5):1493-1506. Epub 2020 Sep 29 doi: 10.1111/all.14580. PMID: 32880997
Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma.
Agache I, Beltran J, Akdis C, Akdis M, Canelo-Aybar C, Canonica GW, Casale T, Chivato T, Corren J, Del Giacco S, Eiwegger T, Firinu D, Gern JE, Hamelmann E, Hanania N, Mäkelä M, Hernández-Martín I, Nair P, O'Mahony L, Papadopoulos NG, Papi A, Park HS, Pérez de Llano L, Posso M, Rocha C, Quirce S, Sastre J, Shamji M, Song Y, Steiner C, Schwarze J, Alonso-Coello P, Palomares O, Jutel M
Allergy 2020 May;75(5):1023-1042. Epub 2020 Feb 24 doi: 10.1111/all.14221. PMID: 32034960
Anaphylaxis-a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis.
Shaker MS, Wallace DV, Golden DBK, Oppenheimer J, Bernstein JA, Campbell RL, Dinakar C, Ellis A, Greenhawt M, Khan DA, Lang DM, Lang ES, Lieberman JA, Portnoy J, Rank MA, Stukus DR, Wang J; Collaborators, Riblet N, Bobrownicki AMP, Bontrager T, Dusin J, Foley J, Frederick B, Fregene E, Hellerstedt S, Hassan F, Hess K, Horner C, Huntington K, Kasireddy P, Keeler D, Kim B, Lieberman P, Lindhorst E, McEnany F, Milbank J, Murphy H, Pando O, Patel AK, Ratliff N, Rhodes R, Robertson K, Scott H, Snell A, Sullivan R, Trivedi V, Wickham A; Chief Editors, Shaker MS, Wallace DV; Workgroup Contributors, Shaker MS, Wallace DV, Bernstein JA, Campbell RL, Dinakar C, Ellis A, Golden DBK, Greenhawt M, Lieberman JA, Rank MA, Stukus DR, Wang J; Joint Task Force on Practice Parameters Reviewers, Shaker MS, Wallace DV, Golden DBK, Bernstein JA, Dinakar C, Ellis A, Greenhawt M, Horner C, Khan DA, Lieberman JA, Oppenheimer J, Rank MA, Shaker MS, Stukus DR, Wang J
J Allergy Clin Immunol 2020 Apr;145(4):1082-1123. Epub 2020 Jan 28 doi: 10.1016/j.jaci.2020.01.017. PMID: 32001253

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