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Subacute combined degeneration of spinal cord

MedGen UID:
113144
•Concept ID:
C0221065
•
Disease or Syndrome
Synonyms: Neuropathy, Subacute Combined Degeneration; Subacute Combined Degeneration; Subacute Combined Neuropathy Degeneration
SNOMED CT: Subacute combined degeneration of spinal cord (60576007); Posterolateral sclerosis (60576007); Vitamin B>12< deficiency disease of spinal cord (60576007); Putnam-Dana syndrome (60576007); Lichtheim's disease (60576007); Subacute combined degeneration (60576007); Neuromyelopathy due to vitamin B12 deficiency (60576007); SACD - Subacute combined degeneration (60576007); Vitamin B>12< deficiency neuropathy (60576007)

Definition

A neuropathy due to VITAMIN B 12 DEFICIENCY or to excessive NITROUS OXIDE inhalation. It is associated with overproduction of the myelinolytic TUMOR NECROSIS FACTOR-ALPHA. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubacute combined degeneration of spinal cord

Professional guidelines

PubMed

Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment.
Paris A, Lake L, Joseph A, Workman A, Walton J, Hayton T, Evangelou N, Lilleker JB, Ayling RM, Nicholl D, Noyce AJ
Pract Neurol 2023 Jun;23(3):222-228. Epub 2023 Feb 22 doi: 10.1136/pn-2022-003631. PMID: 36813556Free PMC Article
Tumors masquerading as neurological diseases: A caution for clinicians in planning diagnosis and treatment.
Vidhya Annapoorni CS, Retnaswami CS, Mailankody P, Katragadda P, Pillai SK, Rangarajan A, Padmanabha H, Pendharkar H
Neurol India 2020 Mar-Apr;68(2):368-372. doi: 10.4103/0028-3886.280647. PMID: 32415012
Differential diagnosis of T2 hyperintense spinal cord lesions: part B.
Bou-Haidar P, Peduto AJ, Karunaratne N
J Med Imaging Radiat Oncol 2009 Apr;53(2):152-9. doi: 10.1111/j.1754-9485.2009.02067.x. PMID: 19527360

Recent clinical studies

Etiology

Subacute combined degeneration of the spinal cord concurrent with acute pulmonary embolism: a case report.
Pang X, Hao Y, Ma L, Zhuo L, Liu L, Feng J
J Int Med Res 2021 May;49(5):3000605211016815. doi: 10.1177/03000605211016815. PMID: 34057834Free PMC Article

Diagnosis

Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review.
Lang C, Huang P, Gao J, Chen Y, He Z
BMC Pediatr 2024 Dec 19;24(1):817. doi: 10.1186/s12887-024-05262-4. PMID: 39695483Free PMC Article
Autoimmune polyglandular syndrome type II presenting as subacute combined degeneration of spinal cord: a neuroendocrinology crossroad.
Bapat P, Kushwaha S, Gupta C, Kirangowda R, Seth V
Rom J Intern Med 2022 Jun 1;60(2):123-126. Epub 2022 Jun 14 doi: 10.2478/rjim-2021-0038. PMID: 34958534
Subacute combined degeneration of the spinal cord concurrent with acute pulmonary embolism: a case report.
Pang X, Hao Y, Ma L, Zhuo L, Liu L, Feng J
J Int Med Res 2021 May;49(5):3000605211016815. doi: 10.1177/03000605211016815. PMID: 34057834Free PMC Article
Rapid healing of a patient with dramatic subacute combined degeneration of spinal cord: a case report.
Roessler FC, Wolff S
BMC Res Notes 2017 Jan 3;10(1):18. doi: 10.1186/s13104-016-2344-4. PMID: 28057043Free PMC Article
MRI in subacute combined degeneration of spinal cord: a case report and review of literature.
Srikanth SG, Jayakumar PN, Vasudev MK, Taly AB, Chandrashekar HS
Neurol India 2002 Sep;50(3):310-2. PMID: 12391459

Therapy

Unusual case of subacute combined degeneration of spinal cord.
Riley CJ
Br Med J 1966 Sep 3;2(5513):566. doi: 10.1136/bmj.2.5513.566. PMID: 5917368Free PMC Article

Prognosis

Autoimmune polyglandular syndrome type II presenting as subacute combined degeneration of spinal cord: a neuroendocrinology crossroad.
Bapat P, Kushwaha S, Gupta C, Kirangowda R, Seth V
Rom J Intern Med 2022 Jun 1;60(2):123-126. Epub 2022 Jun 14 doi: 10.2478/rjim-2021-0038. PMID: 34958534

Clinical prediction guides

Myelopathy during treatment of autoimmune hemolytic anaemia.
Murthy GL, Srinivasan VR, Kaul S, Gayathri K
J Assoc Physicians India 2002 Aug;50:1075-6. PMID: 12421037

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