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TGIF2LX TGFB induced factor homeobox 2 like X-linked [ Homo sapiens (human) ]

Gene ID: 90316, updated on 4-Jan-2025

Summary

Official Symbol
TGIF2LXprovided by HGNC
Official Full Name
TGFB induced factor homeobox 2 like X-linkedprovided by HGNC
Primary source
HGNC:HGNC:18570
See related
Ensembl:ENSG00000153779 MIM:300411; AllianceGenome:HGNC:18570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGIFLX
Summary
This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. Testis-specific expression suggests that this gene may play a role in spermatogenesis. A homolog of this gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 5.8) See more
Orthologs
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Genomic context

See TGIF2LX in Genome Data Viewer
Location:
Xq21.31
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (89921908..89922883)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (88363022..88363997)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (89176907..89177882)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724150 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:88660958-88661203 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:88687522-88688285 Neighboring gene sorcin pseudogene 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:88961378-88962128 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:88962129-88962877 Neighboring gene STAU2 pseudogene 1 Neighboring gene USP12 pseudogene X-linked

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
homeobox protein TGIF2LX
Names
TGF-beta-induced transcription factor 2-like protein
TGFB-induced factor 2-like protein, X-linked
TGFB-induced factor 2-like, X-linked
TGIF-like on the X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138960.4NP_620410.3  homeobox protein TGIF2LX

    See identical proteins and their annotated locations for NP_620410.3

    Status: REVIEWED

    Source sequence(s)
    AL590041
    Consensus CDS
    CCDS14459.1
    UniProtKB/Swiss-Prot
    Q5JRM9, Q8IUE1, Q8TD48
    UniProtKB/TrEMBL
    Q3ZCM9
    Related
    ENSP00000355119.4, ENST00000283891.6
    Conserved Domains (1) summary
    pfam05920
    Location:68107
    Homeobox_KN; Homeobox KN domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    89921908..89922883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    88363022..88363997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)