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Il34 interleukin 34 [ Mus musculus (house mouse) ]

Gene ID: 76527, updated on 9-Dec-2024

Summary

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Official Symbol
Il34provided by MGI
Official Full Name
interleukin 34provided by MGI
Primary source
MGI:MGI:1923777
See related
Ensembl:ENSMUSG00000031750 AllianceGenome:MGI:1923777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010004A03Rik
Summary
Predicted to enable identical protein binding activity and macrophage colony-stimulating factor receptor binding activity. Involved in microglial cell proliferation; positive regulation of gene expression; and positive regulation of oligodendrocyte differentiation. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and mammary gland. Orthologous to human IL34 (interleukin 34). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in adrenal adult (RPKM 23.9), frontal lobe adult (RPKM 16.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Il34 in Genome Data Viewer
Location:
8 E1; 8 57.68 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111467809..111532579, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110741829..110805949, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Vac14 homolog (S. cerevisiae) Neighboring gene nuclear encoded tRNA glycine 10 (anticodon GCC) Neighboring gene predicted gene, 53454 Neighboring gene MTSS I-BAR domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_22681 Neighboring gene predicted gene 15894 Neighboring gene predicted gene, 39250 Neighboring gene STARR-seq mESC enhancer starr_22683 Neighboring gene splicing factor 3b, subunit 3 Neighboring gene small nucleolar RNA, C/D box 111 Neighboring gene predicted gene, 22193

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A neuroprotective role for microglia in prion diseases. Zhu C, et al. J Exp Med, 2016 May 30. PMID 27185853, Free PMC Article
  2. Tumor necrosis factor-α induces interleukin-34 expression through nuclear factor‑κB activation in MC3T3-E1 osteoblastic cells. Yu Y, et al. Mol Med Rep, 2014 Sep. PMID 24970360, Free PMC Article
  3. Interleukin-34 drives macrophage polarization to the M2 phenotype in autoimmune hepatitis. Liu Y, et al. Pathol Res Pract, 2019 Aug. PMID 31201067
  4. Effects of IL-34 on Macrophage Immunological Profile in Response to Alzheimer's-Related Aβ(42) Assemblies. Zuroff LR, et al. Front Immunol, 2020. PMID 32765504, Free PMC Article
  5. IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Wang Y, et al. Nat Immunol, 2012 Jun 24. PMID 22729249, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin-34-NF-kappaB signaling aggravates myocardial ischemic/reperfusion injury by facilitating macrophage recruitment and polarization.
    Title: Interleukin-34-NF-κB signaling aggravates myocardial ischemic/reperfusion injury by facilitating macrophage recruitment and polarization.
  2. IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice.
    Title: IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice.
  3. TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice.
    Title: TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice.
  4. Inactivating IL34 promotes regenerating muscle stem cell expansion and attenuates Duchenne muscular dystrophy in mouse models.
    Title: Inactivating IL34 promotes regenerating muscle stem cell expansion and attenuates Duchenne muscular dystrophy in mouse models.
  5. BMP-2 Genome-Edited Human MSCs Protect against Cartilage Degeneration via Suppression of IL-34 in Collagen-Induced Arthritis.
    Title: BMP-2 Genome-Edited Human MSCs Protect against Cartilage Degeneration via Suppression of IL-34 in Collagen-Induced Arthritis.
  6. Il-34 regulates MAPKs, PI3K/Akt, JAK and NF-kappaB pathways and induces the expression of inflammatory factors in RA-FLS.
    Title: Il-34 regulates MAPKs, PI3K/Akt, JAK and NF-κB pathways and induces the expression of inflammatory factors in RA-FLS.
  7. IL-34 deficiency impairs FOXP3(+) Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis.
    Title: IL-34 deficiency impairs FOXP3(+) Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis.
  8. IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice.
    Title: IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice.
  9. Bone morphogenetic protein 2 controls steroid-induced osteonecrosis of the femoral head via directly inhibiting interleukin-34 expression.
    Title: Bone morphogenetic protein 2 controls steroid-induced osteonecrosis of the femoral head via directly inhibiting interleukin-34 expression.
  10. Interleukin-34 accelerates intrauterine adhesions progress related to CX3CR1(+) monocytes/macrophages.
    Title: Interleukin-34 accelerates intrauterine adhesions progress related to CX3CR1(+) monocytes/macrophages.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables macrophage colony-stimulating factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables macrophage colony-stimulating factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables macrophage colony-stimulating factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-34-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-34-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in microglial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of macrophage chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of macrophage differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macrophage differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of macrophage proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of positive regulation of macrophage proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of monocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of monocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of oligodendrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
interleukin-34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135100.2 → NP_001128572.1  interleukin-34 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001128572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AK008082, AW743837, BY148512
    Consensus CDS
    CCDS52669.1
    UniProtKB/Swiss-Prot
    B2ZC71, B2ZC72, Q8R1R4, Q9D8F2
    Related
    ENSMUSP00000076120.5, ENSMUST00000076846.11
    Conserved Domains (1) summary
    pfam15036
    Location:28 → 184
    IL34; Interleukin 34

  2. NM_029646.3 → NP_083922.1  interleukin-34 isoform 2 precursor

    See identical proteins and their annotated locations for NP_083922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region which results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK008082, AW743837, BY148512
    Consensus CDS
    CCDS52670.1
    UniProtKB/Swiss-Prot
    Q8R1R4
    Related
    ENSMUSP00000114398.2, ENSMUST00000150680.2
    Conserved Domains (1) summary
    pfam15036
    Location:28 → 150
    IL34; Interleukin 34

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111467809..111532579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531485.5 → XP_006531548.1  interleukin-34 isoform X2

    See identical proteins and their annotated locations for XP_006531548.1

    UniProtKB/Swiss-Prot
    Q8R1R4
    Conserved Domains (1) summary
    pfam15036
    Location:28 → 183
    IL34; Interleukin 34

  2. XM_030243837.2 → XP_030099697.1  interleukin-34 isoform X1

    UniProtKB/Swiss-Prot
    B2ZC71, B2ZC72, Q8R1R4, Q9D8F2
    Conserved Domains (1) summary
    pfam15036
    Location:28 → 184
    IL34; Interleukin 34

  3. XM_036154368.1 → XP_036010261.1  interleukin-34 isoform X1

    UniProtKB/Swiss-Prot
    B2ZC71, B2ZC72, Q8R1R4, Q9D8F2
    Conserved Domains (1) summary
    pfam15036
    Location:28 → 184
    IL34; Interleukin 34

  4. XM_036154367.1 → XP_036010260.1  interleukin-34 isoform X1

    UniProtKB/Swiss-Prot
    B2ZC71, B2ZC72, Q8R1R4, Q9D8F2
    Conserved Domains (1) summary
    pfam15036
    Location:28 → 184
    IL34; Interleukin 34

  5. XM_036154366.1 → XP_036010259.1  interleukin-34 isoform X1

    UniProtKB/Swiss-Prot
    B2ZC71, B2ZC72, Q8R1R4, Q9D8F2
    Conserved Domains (1) summary
    pfam15036
    Location:28 → 184
    IL34; Interleukin 34

  6. XM_030243838.2 → XP_030099698.1  interleukin-34 isoform X3

    Conserved Domains (1) summary
    pfam15036
    Location:28 → 149
    IL34; Interleukin 34
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1R4.1 GenPept UniProtKB/Swiss-Prot:Q8R1R4

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