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Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 [ Mus musculus (house mouse) ]

Gene ID: 320207, updated on 9-Dec-2024

Summary

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Official Symbol
Pik3r5provided by MGI
Official Full Name
phosphoinositide-3-kinase regulatory subunit 5provided by MGI
Primary source
MGI:MGI:2443588
See related
Ensembl:ENSMUSG00000020901 AllianceGenome:MGI:2443588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p101; Foap2; F730038I15Rik
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity and G-protein beta/gamma-subunit complex binding activity. Predicted to be involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; phosphatidylinositol metabolic process; and positive regulation of intracellular signal transduction. Predicted to be located in centriolar satellite; cytosol; and membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Is expressed in brain and retina nuclear layer. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 3 and colon cancer. Orthologous to human PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in thymus adult (RPKM 27.4), spleen adult (RPKM 14.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Pik3r5 in Genome Data Viewer
Location:
11 B3; 11 41.69 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68322951..68388675)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68432125..68497849)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29816 Neighboring gene predicted gene, 31954 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68245166-68245319 Neighboring gene STARR-positive B cell enhancer mm9_chr11:68245418-68245719 Neighboring gene predicted gene, 32046 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68276328-68276529 Neighboring gene STARR-positive B cell enhancer ABC_E3959 Neighboring gene STARR-positive B cell enhancer ABC_E6997 Neighboring gene phosphoinositide-3-kinase regulatory subunit 5 Neighboring gene STARR-seq mESC enhancer starr_29817 Neighboring gene major facilitator superfamily domain containing 6-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5. Huang Z, et al. J Muscle Res Cell Motil, 2023 Mar. PMID 36512272
  2. Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Suire S, et al. Nat Cell Biol, 2006 Nov. PMID 17041586
  3. lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization. Han X, et al. Cell Mol Biol Lett, 2023 Oct 7. PMID 37805473, Free PMC Article
  4. The regulatory subunits of PI3Kγ control distinct neutrophil responses. Deladeriere A, et al. Sci Signal, 2015 Jan 20. PMID 25605974
  5. Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils. Rynkiewicz NK, et al. Sci Signal, 2020 Nov 3. PMID 33144519, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization.
    Title: lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization.
  2. Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5.
    Title: Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5.
  3. Gbetagamma is a direct regulator of endogenous p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse neutrophils.
    Title: Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-3-kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables G-protein beta/gamma-subunit complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex ISO
Inferred from Sequence Orthology
more info
  
part_of phosphatidylinositol 3-kinase complex, class IA ISO
Inferred from Sequence Orthology
more info
  
part_of phosphatidylinositol 3-kinase complex, class IB ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoinositide 3-kinase regulatory subunit 5
Names
PI3-kinase p101 subunit
PI3-kinase regulatory subunit 5
p101-PI3K
phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
phosphoinositide-3-kinase, regulatory subunit 5, p101
ptdIns-3-kinase p101
ptdIns-3-kinase regulatory subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177320.2 → NP_796294.2  phosphoinositide 3-kinase regulatory subunit 5

    See identical proteins and their annotated locations for NP_796294.2

    Status: VALIDATED

    Source sequence(s)
    AK089483, AK149847, AL606831
    Consensus CDS
    CCDS24865.1
    UniProtKB/Swiss-Prot
    Q3TU01, Q3UDZ2, Q5SW28, Q8C215, Q8CGQ7
    UniProtKB/TrEMBL
    A1A4T4
    Related
    ENSMUSP00000021283.8, ENSMUST00000021283.8
    Conserved Domains (1) summary
    pfam10486
    Location:6 → 871
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    68322951..68388675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533548.3 → XP_006533611.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

    See identical proteins and their annotated locations for XP_006533611.1

    UniProtKB/Swiss-Prot
    Q3TU01, Q3UDZ2, Q5SW28, Q8C215, Q8CGQ7
    UniProtKB/TrEMBL
    A1A4T4
    Conserved Domains (1) summary
    pfam10486
    Location:6 → 871
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SW28.1 GenPept UniProtKB/Swiss-Prot:Q5SW28

Gene LinkOut

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