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ANAPC2 anaphase promoting complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 29882, updated on 10-Dec-2024

Summary

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Official Symbol
ANAPC2provided by HGNC
Official Full Name
anaphase promoting complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:19989
See related
Ensembl:ENSG00000176248 MIM:606946; AllianceGenome:HGNC:19989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC2
Summary
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 16.5), spleen (RPKM 12.2) and 25 other tissues See more
Orthologs
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Genomic context

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See ANAPC2 in Genome Data Viewer
Location:
9q34.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137174784..137188560, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149412464..149426223, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140069236..140083012, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20587 Neighboring gene leucine rich repeat containing 26 Neighboring gene microRNA 3621 Neighboring gene uncharacterized LOC124902315 Neighboring gene transmembrane protein 210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140069251-140070084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20588 Neighboring gene SS nuclear autoantigen 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140088338-140089216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140089217-140090094 Neighboring gene taperin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20590

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex. Mo M, et al. J Gen Virol, 2010 Dec. PMID 20826619
  2. The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients. Rahimi H, et al. Adv Med Sci, 2015 Sep. PMID 26046517
  3. SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs. van der Lelij P, et al. EMBO J, 2014 Nov 18. PMID 25257309, Free PMC Article
  4. DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway. Shang ZF, et al. Int J Biol Sci, 2015. PMID 26221070, Free PMC Article
  5. Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis. Lee SJ, et al. BMC Cancer, 2012 Jan 26. PMID 22280307, Free PMC Article

See all (131) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors showed, in vitro, a direct interaction between Orf virus anaphase promoting complex regulator and APC2 and its interference with interactions between APC11 and APC2.
    Title: Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex.
  2. A transcriptome-wide analysis revealed that SNW1 or PRPF8 depletion affects the splicing of specific introns in a subset of pre-mRNAs, including pre-mRNAs encoding the cohesion protein sororin and the APC/C subunit APC2.
    Title: SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.
  3. The results showed that APC2 and APC7 subunits were both over expressed in cancer cell lines
    Title: The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients.
  4. The regulation of Mdm2 by the E3 ubiquitin ligase APC/C is shown. It has important therapeutic implications for tumors with Mdm2 overexpression.
    Title: The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2.
  5. anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonists are novel regulators of cell growth and apoptosis
    Title: Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.
  6. It proposes a role for APC/C(Cdh1) in modulating the status of PCNA monoubiquitination and UV DNA repair before S phase entry.
    Title: APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.
  7. APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.
    Title: APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.
  8. Results describe the locations of Cdh1 and Apc2 in the anaphase-promoting complex/cyclosome of human and Xenopus laevis.
    Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of anaphase promoting complex subunit 2 (ANAPC2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
Knockdown of anaphase promoting complex subunit 2 (ANAPC2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with anaphase promoting complex subunit 2 (ANAPC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with anaphase promoting complex subunit 2 (ANAPC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaphase-promoting complex-dependent catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein branched polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of meiotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of anaphase-promoting complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 2
Names
cyclosome subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013366.4 → NP_037498.1  anaphase-promoting complex subunit 2

    See identical proteins and their annotated locations for NP_037498.1

    Status: REVIEWED

    Source sequence(s)
    BC032503, BM925063
    Consensus CDS
    CCDS7033.1
    UniProtKB/Swiss-Prot
    Q5VSG1, Q96DG5, Q96GG4, Q9P2E1, Q9UJX6
    Related
    ENSP00000314004.2, ENST00000323927.3
    Conserved Domains (2) summary
    smart01013
    Location:757 → 817
    APC2; Anaphase promoting complex (APC) subunit 2
    pfam00888
    Location:512 → 694
    Cullin; Cullin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    137174784..137188560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423275.1 → XP_047279231.1  anaphase-promoting complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    B4DGH7

  2. XM_047423274.1 → XP_047279230.1  anaphase-promoting complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    B4DGH7

  3. XM_047423276.1 → XP_047279232.1  anaphase-promoting complex subunit 2 isoform X3

    UniProtKB/TrEMBL
    B4DGH7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    149412464..149426223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362821.1 → XP_054218796.1  anaphase-promoting complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    B4DGH7

  2. XM_054362820.1 → XP_054218795.1  anaphase-promoting complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    B4DGH7

  3. XM_054362822.1 → XP_054218797.1  anaphase-promoting complex subunit 2 isoform X3

    UniProtKB/TrEMBL
    B4DGH7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UJX6.1 GenPept UniProtKB/Swiss-Prot:Q9UJX6

Gene LinkOut

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