Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Dysbiosis is the condition of having imbalances in the microbial communities either in or on the body. Dysbiosis is associated with many diseases, such as inflammatory bowel disease and chronic fatigue syndrome.
Because of its complex pathophysiology, the management of inflammatory bowel disease as well as its fibrotic complication has become a global challenge. Here, the authors show a probiotic inulin hydrogel loaded with polypyrrole (PPy) nanozymes and antifibrotic drug pirfenidone (PFD) (PPy/PFD@Inulin gel) designed for the concurrent amelioration of IBD and its fibrotic complication.
Here, the authors profile the gut microbiome of Ethiopian children suffering from acute and prolonged diarrhea, showing the latter group to exhibit a higher degree of microbial imbalance, characterized by a reduction of gut commensals and an enrichment of potential pathogens.
In this randomized, double-blind, placebo-controlled trial young adults with chronic diarrhea were randomized into treatment and placebo groups to evaluate the effects of the probiotic Lactiplantibacillus plantarum P9 strain administraiton. The primary endpoint was the diarrhea symptom severity score. Both intention-to-treat and per-protocol analyses reveal a modest yet statistically significant reduction in diarrhea severity.
In this Journal Club, Tao Zuo discusses a study by Gogokhia et al. who found that gut bacteriophages can alter mucosal immunity to impact mammalian health.
To therapeutically modulate gut microbial ecosystems, a better understanding of gut ecology is key. High-throughput in vitro ecology provides a tool with the necessary power to address these needs and interpersonal treatment response variation.
This study shows that a high-fat diet and antibiotic treatment impair mitochondrial bioenergetics, which increases epithelial oxygenation and triggers dysbiosis and pre-inflammatory bowel disease.