Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury

Affiliations

• 1 Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, and New Cornerstone Science Laboratory, Shandong University, Jinan 250012, China; Department of Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China.
• 2 Key Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China.
• 3 Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
• 4 Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan 250012, China.
• 5 School of Pharmacy, Binzhou Medical University, Yantai, China.
• 6 Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, and New Cornerstone Science Laboratory, Shandong University, Jinan 250012, China.
• 7 Centre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
• 8 Department of General Surgery, Qilu Hospital, Gheeloo College of Medicine, Shandong University, Jinan 250012, China. Electronic address: xuyunfei1988@126.com.
• 9 State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China; Department of Otolaryngology Head and Neck Surgery, Sichuan, Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610000, China. Electronic address: renjiec@seu.edu.cn.
• 10 Key Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, School of Basic Medical Sciences, Shandong University, Jinan 250012, China; Shandong Key Laboratory of Mental Disorders and Intelligent Control, Shandong University, Jinan 250012, China. Electronic address: yuxiao@sdu.edu.cn.
• 11 Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, and New Cornerstone Science Laboratory, Shandong University, Jinan 250012, China; NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China. Electronic address: sunjinpeng@sdu.edu.cn.
• 12 Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. Electronic address: chubo123@sdu.edu.cn.