Search Results (454)

Background/Objectives: Body posture is developmentally variable and individually diversified. As a chain of numerous unconditioned and conditioned reflexes, it is, in its essence, a psychomotor habit. The aim of the study was to create an original typology of body posture based on measurements using the Diers Formetric III 4D system. Methods: The research included 303 children aged 10–12. Results: Taking the ranges of standards for the angle of thoracic kyphosis (42–55°) and lumbar lordosis (33–47°) into account, it was shown that there are nine types of body posture. These are as follows: reduced kyphosis, reduced lordosis (K < 42°; L < 33°); reduced kyphosis, normal lordosis (K < 42°; 33° ≤ L ≤ 47°); reduced kyphosis, increased lordosis (K < 42°; L > 47°); normal kyphosis, reduced lordosis (42° ≤ K ≤ 55°; L < 33°); normal kyphosis, normal lordosis (42° ≤ K ≤ 55; 33° ≤ L ≤ 47°); normal kyphosis, increased lordosis (42° ≤ K ≤ 55°; L > 47°); increased kyphosis, reduced lordosis (K > 55°, L < 33°); increased kyphosis, normal lordosis (K > 55°; 33° ≤ L ≤ 47°); and increased kyphosis, increased lordosis (K > 55°; L > 47°). Conclusions: In the final evaluation of the Diers Formetric III 4D examination, the traditional division into round, concave, round-concave, and flat backs should be supplemented and expanded to include the nine posture types mentioned above. This will enable a more precise selection of corrective exercises, which will significantly improve their quality and effectiveness. Full article

New analytical formulas are derived for the rank and the local discrepancy of Farey fractions. The new rank formula is applicable to all Farey fractions and involves sums of a lower order compared to the searched one. This serves to establish a new unconditional estimate for the local discrepancy of Farey fractions that decrease with the order of the Farey sequence. This estimate improves the currently known estimates. A new recursive expression for the local discrepancy of Farey fractions is also given. A second new unconditional estimate of the local discrepancy of any Farey fraction is derived from a sum of the Mertens function, again, improving the currently known estimates. Full article

Background: The influenza virus’s high mutation rate requires the annual reformulation and administration of the vaccine. Therefore, its vaccine effectiveness (VE) must be evaluated annually. Aim: Estimate the effectiveness of the influenza vaccine and analyze the impact of age, seasonal variations, and the vaccination to sample collection interval on VE. Methods: The study used a test-negative case–control (TNCC) design to collect data from patients under 18 years of age who presented with acute respiratory infection (ARI) symptoms and underwent influenza virus testing at a national children’s regional medical center in Guangdong Province between October 2021 and January 2024, spanning three influenza seasons. VE was estimated using unconditional logistic regression. Results: A total of 27,670 patient data entries were analyzed. The VE against all influenza viruses across the three seasons was 37% (95% CI: 31–43), with the lowest VE of 24% (95% CI: 8–37) observed in the 2021–2022 season. In children aged 0.5 to <3 years, the VE was 32% (95% CI: 19–43). The effectiveness for samples collected at intervals of 0.5–2 months, 3–6 months, and over 6 months after vaccination was 39% (95% CI: 32–46), 30% (95% CI: 19–40), and 28% (95% CI: 5–46). Conclusions: Across three influenza seasons, at least one-third of vaccinated individuals were protected from influenza in outpatient settings. Given that children are at high risk, improving vaccination management is recommended, and parents should be encouraged to vaccinate their children before each influenza season. Full article

Urticaria is a debilitating skin condition affecting up to 20% of the global population, characterized by erythematous, maculopapular lesions and significant quality of life impairment. This study focused on the role of interleukin 33 (IL-33) and its polymorphisms, particularly SNP rs1929992, in chronic spontaneous urticaria (CSU). Using demographic, clinical, and laboratory data from CSU patients and controls, we estimated allele and genotype frequencies, Hardy–Weinberg equilibrium condition, and serum IL-33 levels, using unconditional binomial logistic regression for association analysis. Results revealed that CSU patients had significantly higher frequencies of the minor allele of IL-33 rs1929992 compared to controls (31.25% vs. 17.35%, p = 0.024), and carriers of the GA genotype exhibited increased odds of CSU (adjusted OR = 2.208, p ≤ 0.001). Additionally, serum IL-33 levels were markedly elevated in CSU patients, particularly those with the GA genotype. The findings suggest that the IL-33 SNP is associated with an increased susceptibility to CSU, emphasizing its potential as a diagnostic and therapeutic biomarker. This study underscores the genetic and immunological underpinnings of CSU, paving the way for personalized treatment approaches. Full article

Background/Objectives: Gastric cancer is one of the leading malignancies worldwide. B vitamins play important roles in DNA synthesis and methylation because they are considered co-enzymes in one-carbon metabolism. There is inconclusive evidence regarding the associations between dietary vitamins B₁, B₂, and B₆ with the risk of gastric cancer in different epidemiologic studies. We, therefore, investigated such associations in a hospital-based case-control study comprising 1182 incident cases of gastric cancer and 2995 controls in Vietnam. Methods: Dietary vitamins B₁, B₂, and B₆ were derived from a semi-quantitative validated food frequency questionnaire. An unconditional logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer in relation to dietary intake of vitamins B₁, B₂, and B₆. Results: Overall, dietary vitamins B₁ (OR_{per-SD increment} = 0.83; 95% CI: 0.78–0.89; P_trend < 0.001) and B₆ (OR_{per-SD increment} = 0.88; 95% CI: 0.81–0.94; P_trend < 0.001) were associated with a reduced risk of gastric cancer. Compared with the lowest quintile, the ORs (95% CIs) of gastric cancer for quintiles 2, 3, 4, and 5 of the vitamin B₁ intake were 0.64 (0.51–0.79), 0.54 (0.43–0.69), 0.57 (0.44–0.74), and 0.42 (0.31–0.55), respectively; for vitamin B₆ intake, quintiles 2, 3, 4, and 5 were 0.53 (0.42–0.66), 0.54 (0.42–0.70), 0.61 (0.46–0.81), and 0.46 (0.33–0.63), respectively. This inverse association was not different across sex, BMI, and smoking statuses. No association was found between dietary vitamin B₂ and gastric cancer risk. Conclusions: Dietary vitamins B₁ and B₆ were associated with a reduced risk of gastric cancer in the Vietnamese population. Future studies are warranted to replicate our findings, which also have great implications for gastric cancer prevention and control programs in low- and middle-income countries. Full article

Background: glucocorticoids may play an important role in the formation of fear memory, which is relevant to the neurobiology of post-traumatic stress disorder (PTSD). In our previous study, we showed the glucocorticoid receptor (GR) forms a protein complex with FKBP51, which prevents translocation of GR into the nucleus to affect gene expression; this complex is elevated in PTSD patients and by fear-conditioned learning in mice, and disrupting this complex blocks the storage and retrieval of fear-conditioned memories. The timing of release of glucocorticoid relative to the formation of a traumatic memory could be important in this process, and remains poorly understood. Methods and Results: we mapped serum corticosterone over time after fear conditioning in cardiac blood samples from male and female mice, as well as adult and aged mice using ELISA. We show a significant alteration in serum corticosterone after conditioning; notably, levels spike after 30 min but drop lower than unconditioned controls after 24 h. We further investigate the effect of glucocorticoid on GR phosphorylation and localization in HEK 293T cells by Western blot. Hydrocortisone treatment promotes phosphorylation and nuclear translocation of GR. Conclusions: these data contribute to our understanding of the processes linking stress responses to molecular signals and fear memory, which is relevant to understanding the shared mechanisms related to PTSD. Full article

Background: Obesity poses an enormous public health and economic burden worldwide. Visceral fat accumulation is associated with various metabolic and cardiovascular consequences, resulting in an increased prevalence of atherosclerotic conditions. We aimed to examine the impact of low-and moderate-intensity aerobic training on several anthropometric and cardiorespiratory parameters and markers of atherosclerosis, including inflammation, serum levels of lipoproteins and adipokines of extremely obese patients in poor condition. Methods: Forty severely obese patients were recruited and randomized into two groups, Group 1 and Group 2, for a six-week inpatient study. Group 1 received moderate-intensity (40–60% heart rate reserve) and Group 2 received low-intensity (30–39% of heart rate reserve) aerobic training combined with resistance training. The patients’ cardiorespiratory functions were assessed by ergospirometry. Anthropometric data were recorded, body composition was analyzed and functional tests were performed. We also investigated serum lipids and high-sensitive C-reactive protein levels and calculated the homeostatic model assessment-insulin resistance indices and adipokine levels as predictive biomarkers. Results: Functional abilities and some biochemical parameters, such as homeostatic model assessment-insulin resistance, serum lipids, apolipoprotein A and apolipoprotein-B improved in both groups in a positive direction. However, cardiorespiratory capacity and the serum levels of high-sensitive C-reactive protein and Lipocalin-2 decreased, while irisin and paraoxonase 1 increased significantly, but only in Group 1. Conclusions: Six weeks of aerobic training, regardless of its intensity, could induce favorable changes in functional tests, body composition and serum lipids, even in severely obese, extremely unconditioned patients in both groups. However, moderate-intensity aerobic training should at least increase cardiorespiratory capacity and yield a better lipid profile oxidative status and inflammation profile. Full article

The presented research on adhesives was conducted with the aim of supporting the design of composite repairs for composite aircraft structures that can withstand specific environmental conditions. Double-sided strap joint specimens of epoxy-based CFRP adherents and straps were bonded by two types of adhesives. Room-temperature curing epoxy adhesives EC-9323 and EA-9395 were used for bonding. The specimens’ shear strength and failure modes were evaluated under four different environmental conditions from −72 °C up to 70 °C unconditioned and at 70 °C after humidity conditioning. The results show that EC-9323 performed excellently at room temperature, but very poorly at elevated temperatures after hot–wet conditioning. Adhesive EA-9395 performed consistently well across all tested conditions. The failure mode analysis explained the performance trends and the effect of the environment on the fractured surface. This study will support proper repair design and verification of numerical simulations. The novelty of this article lies in its combined analysis of multiple environmental factors, providing a more realistic assessment of joint performance. Full article

In the process of gradually upgrading aquaculture to the information and intelligence industries, it is usually necessary to collect images of underwater fish. In practical work, the quality of underwater images is often affected by water clarity and light refraction, resulting in most fish images not fully displaying the entire fish body. Image inpainting helps infer the occluded fish image information based on known images, thereby better identifying and analyzing fish populations. When using existing image inpainting methods for underwater fish images, limited by the small datasets available for training, the results were not satisfactory. Lightweight Multi-scales Feature Diffusion (LMF-Diffusion) is proposed to achieve results closer to real images when dealing with image inpainting tasks from small datasets. LMF-Diffusion is based on guided diffusion and flexibly extracts features from images at different scales, effectively capturing remote dependencies among pixels, and it is more lightweight, making it more suitable for practical deployment. Experimental results show that our architecture uses only $48.7\%$ of the parameter of the guided diffusion model and produces inpainting results closer to real images in our dataset. Experimental results show that LMF-Diffusion enables the Repaint method to exhibit better performance in underwater fish image inpainting. Underwater fish image inpainting results obtained using our LMF-Diffusion model outperform those produced by current popular image inpainting methods. Full article

A digital economy parallel with green development holds profound significance for achieving sustainability. The primary objective of this study was to explore the synergistic interaction effects between the digital economy and green development in China and forecast their future development. This study analyzed the spatio-temporal characteristics of provincial digital economy and green development in China by integrating a combined assignment method, an unconditional spatial kernel density estimation method, and a standard deviation ellipse model. The interplay between the digital economy and green development was examined using a panel vector autoregression model. Additionally, digital economy and green development levels were forecasted using univariate time series and radial basis function kernel ε-support vector regression models. The results indicate that both the digital economy and green development levels in China exhibited an upward trend from 2013 to 2021, with the digital economy increasing at a faster rate. However, both domains demonstrated regional disparities in their development processes. The mutual interaction between the digital economy and green development intensified as the lag period increased. The digital economy contributed 21% to green development, whereas green development contributed 18% to the digital economy. The initial effect of the digital economy on green development was negative, however, this impact gradually diminished over time. Additionally, the influence of green development on the digital economy was shown to follow a consistent trend of transitioning from negative to positive across the eastern, central, and western regions. Therefore, it can be seen that the digital economy exerts a sustainable impact on green development, albeit with a one-phase lag. This research provides a scientific basis for the deep integration of the digital economy and green development, thereby fostering sustainable socioeconomic growth. Full article

Introduction: Our objective in this article was to develop a predictive model for obesity in the third trimester of pregnancy using the plasma and clinical biomarkers that are managed within the Chromosomopathies Programme in the Andalusian Public Healthcare System. Methods: The epidemiological design was observational, of the unmatched case–control type. The geographical environment was the Seville Primary Healthcare District (DSAP Sevilla). The information was collected between 2011 and 2021. The reference cohort consisted of women who had carried a pregnancy to term. The variables and biomarkers studied correspond to those managed within the primary-care Pregnancy Integrated Care Pathway (ICP). Unconditional binary logistic regression (BLR) models were created, with the outcome variable being whether or not the women were obese in their third trimester of pregnancy. Results: A total of 423 controls and 104 cases of obesity were obtained for women in their third trimester who had not been obese in their first trimester. The average age for the sample group (P50) was 34 years old. The final, most parsimonious model included the variables PAPP-A (p = 0.074), beta-hCG (p = 0.1631), and systolic blood pressure (SBP) (p = 0.085). ROC curve = 0.75 (C.I. at 95%: 0.63–0.86). Discussion: The results of this research can only be extrapolated to primary care and to pregnancies with no complications. PAPP-A has been shown in our research to be a significant predictor of obesity risk in the third trimester of pregnancies with no complications (OR = 0.53; C.I. at 95%: 0.39–0.66; p = 0.04 in the single-variant study; OR = 0.58; C.I. at 95%: 0.29–0.93; p = 0.074 in the multi-variant analysis). This predictive capacity is further enhanced from an operational perspective by beta-hCG and 12-week SBP. Full article

In this paper, we will introduce a compact alternating direction implicit (ADI) difference scheme for solving the two-dimensional (2D) time fractional nonlinear Schrödinger equation. The difference scheme is constructed by using the $L1-2-3$ formula to approximate the Caputo fractional derivative in time and the fourth-order compact difference scheme is adopted in the space direction. The proposed difference scheme with a convergence accuracy of $O({\tau }^{1+\alpha }+h_x^4+h_y^4)(\alpha \in (0,1))$ is obtained by adding a small term, where $\tau$, $h_x$, $h_y$ are the temporal and spatial step sizes, respectively. The convergence and unconditional stability of the difference scheme are obtained. Moreover, numerical experiments are given to verify the accuracy and efficiency of the difference scheme. Full article

If asphalt pavements are exposed to cold weather conditions and high humidity for long periods of time, cracking of the pavement is an inevitable consequence. In such cases, it would be a good decision to focus on the filler material, which plays an important role in the performance variation in the hot asphalt mixtures used in the pavement. Although the use of hydrated lime as a filler material in hot asphalt mixtures is a common method frequently recommended to eliminate the adverse effects of low temperature and to keep moisture sensitivity under control in asphalt pavements, the sensitivity of the quantities of the material cannot be ignored. Therefore, in this study, an amount of filler in the mixture was replaced with hydrated lime (HL) filler additive at different rates of 0%, 1%, 2%, 3% and 4%. These asphalt briquettes, designed according to the Marshall method, have optimum asphalt contents for samples with specified HL content. In this study, where the temperature effect was examined at five different levels of −10 °C, −5 °C, 0 °C, 5 °C and 25 °C, the samples were produced in two different groups, conditioned and unconditioned, in order to examine the effect of water. The indirect tensile strength (ITS) test was applied on the produced samples. Experimental study showed that HL additive strengthened the material at low temperatures and made it more resistant to cold weather conditions and humidity. In the second part of the study, two different prediction models with varying configurations were introduced using nonlinear regression and feed-forward neural networks (FFNNs) and the best prediction performance among these was investigated. Examination of the performance measures of the prediction models indicated that ITS can be accurately predicted using both methods. As a result of comparing the developed models with the experimental data, the model provides significant contributions to the evaluation of the relationship between the ITS values obtained with the specified conditioning, temperature changes and HL contents. Full article

This paper addresses the valuation of European options, which involves the complex and unpredictable dynamics of fractal market fluctuations. These are modeled using the $\alpha$-order time-fractional Black–Scholes equation, where the Caputo fractional derivative is applied with the parameter $\alpha$ ranging from 0 to 1. We introduce a novel, high-order numerical scheme specifically crafted to efficiently tackle the time-fractional Black–Scholes equation. The spatial discretization is handled by a tailored finite point scheme that leverages exponential basis functions, complemented by an L1-discretization technique for temporal progression. We have conducted a thorough investigation into the stability and convergence of our approach, confirming its unconditional stability and fourth-order spatial accuracy, along with $(2-\alpha )$-order temporal accuracy. To substantiate our theoretical results and showcase the precision of our method, we present numerical examples that include solutions with known exact values. We then apply our methodology to price three types of European options within the framework of the time-fractional Black–Scholes model: (i) a European double barrier knock-out call option; (ii) a standard European call option; and (iii) a European put option. These case studies not only enhance our comprehension of the fractional derivative’s order on option pricing but also stimulate discussion on how different model parameters affect option values within the fractional framework. Full article

The Gaussian signaling strategy with power control for the Gaussian Z-interference channel with weak interference is reviewed in this paper. In particular, we study the various communication strategies that may arise at various points of the capacity region and identify the locations of the phase transitions between the various strategies. The Gaussian Z-interference channel with weak interference is known to have two critical points in its capacity region, where the slope of the region shows a sudden change. They occur at the points of the unconditional maximum rate for one of the users and the maximum rate that can be accommodated by the other user. In this paper, we discuss additional critical points (locations of phase transitions) in the achievable region of this channel. These turn out to be second-order phase transitions, i.e., we do not observe a discontinuous slope in the achievable rate region, but there is a discontinuity in the second derivative of the rate contour of the achievable region. This review paper is mainly based on some of our ITA (Information Theory and Applications Workshop, UCSD, San Diego, CA, USA) papers since 2011. Full article