Search Results (2,252)

Selenium nanoparticles (SeNPs) have drawn considerable attention to biomedicine, the food industry, and cosmetics due to their strong antioxidant potential and low toxicity. However, their poor stability limits broader applications. A promising strategy to overcome this limitation involves combining SeNPs with polysaccharides. In this study, selenium nanoparticles (MOLP-SeNPs) were synthesized using Moringa oleifera Lam. polysaccharide (MOLP) as a stabilizer and dispersant within a redox system comprising sodium selenite and ascorbic acid. The structural characteristics of the synthesized MOLP-SeNPs were analyzed using spectroscopy. Additionally, their thermal and storage stability was evaluated, and their antioxidant activity was explored through simulated digestion in vitro and a HepG2 cell oxidative stress model. The results demonstrated that well-dispersed, zero-valent MOLP-SeNPs showing a mean particle size of 166.58 nm were synthesized successfully through an MOLP-to-sodium selenite ratio of 2.8:3 at pH 7.3 and 35 °C. The MOLP-SeNPs exhibited excellent stability during preparation. In simulated in vitro digestion and H₂O₂-induced oxidative stress experiments on HepG2 cells, MOLP-SeNPs displayed strong free radical scavenging capacity while improving antioxidant activity. Cellular experiments deeply revealed that pretreatment with MOLP-SeNPs significantly improved cell viability and provided a pronounced protective effect against oxidative damage. In conclusion, MOLP-SeNPs represent a novel antioxidant with promising applications in food and biomedicine. Full article

The proteasomal system of protein degradation is crucial for various cellular processes, including transduction of signals and differentiation of cells. Proteasome activity rises after various traumatic stressors such as hyperoxia, radiation, or oxidative damage. Removal of damaged proteins is essential to provide the necessary conditions for cell repair. Several studies report the activation of the proteasomal degradation system after thermal injury, CNS injury, abdominal trauma, ischemia-reperfusion injury, and possible clinical implications of the use of proteasome inhibitors. It is important to highlight the distinct and crucial roles of UCHL1, 26S, and 20S proteasome subunits as biomarkers. UCHL1 appears to be particularly relevant for identifying brain and neuronal damage and in advancing the diagnosis and prognosis of traumatic brain injury (TBI) and other neurological conditions. Meanwhile, the 26S and 20S proteasomes may serve as markers for peripheral tissue damage. This differentiation enhances our understanding and ability to target specific types of tissue damage in clinical settings. Full article

One of the major concerns for battery electric vehicles (BEVs) is the occurrence of thermal runaway (TR), usually of a single cell, and its propagation to adjacent cells in a battery pack. To guarantee sufficient safety for the vehicle occupants, the TR mechanisms must be known and predictable. In this work, we compare thermal runaway scenarios using different initiation protocols (heat–wait–seek, constant heating, nail penetration) and battery chemistries (nickel manganese cobalt oxide, NMC; lithium iron phosphate, LFP; and sodium-ion batteries, SIB) with the cells in a fully charged state. Our goal is to specifically trigger a variety of different possible TR scenarios (internal failure, external hotspot, mechanical damage) with different types of chemistries to obtain reliable data that are subsequently employed for modeling and prediction of the phenomenon. The safety of the tested cells depending on their chemistry can be summarized as LFP > SIB >> NMC. The data of the TR experiments were used as the basis for high-fidelity modeling and predicting of TR phenomena in 3D. The models simulated reaction rates, represented by the typically employed Arrhenius approach. The effects of the investigated TR triggering methods and cell chemistries were represented with sufficient accuracy, enabling the application of the models for the simulation of thermal propagation in battery packs. Full article

The comonomer bisphenol A (BPA) finds applications in the plastics industry, where it is used in the production of polycarbonates, plastics, PVC, thermal paper, epoxy and vinyl ester resins, and polyurethane. The water, with which many of these materials come into contact, is one of the main sources of human exposure to BPA. When ingested or touched, BPA can damage organs, disrupt the endocrine and immune systems, generate inflammatory responses, and be involved in genotoxic processes. Therefore, the need to develop effective techniques for removing BPA from aqueous environments is imperative. This paper provides a comprehensive review regarding the effective removal of BPA from water, focusing on the performance and adsorption mechanisms of various adsorbents based on chitosan and chitosan composites. The chemical and physical factors, adsorption kinetics and models governing the adsorption process of BPA in chitosan materials are also examined. This review outlines that, despite considerable progress in the absorption of bisphenol using chitosan gels, further research is necessary to assess the efficacy of these adsorbents in treating real wastewater and in large-scale manufacture. Full article

Flexible wearable devices and solar flexible units often use thermally sensitive organic materials as substrates, which are prone to thermal damage during the bonding process in 3D packaging, leading to chip deformation or failure. Multicomponent solders, with well-designed multicomponent metallic elements, exhibit unique low-melting-point characteristics. The application of low-temperature multicomponent solders in electronic packaging can significantly reduce bonding temperatures and minimize thermal damage to chips. This paper reviews the wettability and preparation methods of low-temperature multicomponent solders, and concludes the effect of different metallic elements on the solders. Additionally, this paper discusses the research on interfacial reactions, mechanical properties of low-temperature multicomponent solder joints, providing valuable insights for future research and development in this field. Full article

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is thermoplastic, biodegradable, and derived from renewable-source polymers; thus, it can be used as an alternative to traditional synthetic polymers to reduce damage to the environment. The production of cassava starch generates a high amount of cassava bagasse (about 93% of processed roots) in the separation step of starch. The utilization of this waste is essential due to the difficulty of transportation and storage, besides the detriment caused to the environment by its incorrect disposal. This work aimed to evaluate the possibility of using cassava bagasse as a reinforcement in the production of biocomposites with PHBV matrices by compression molding. The physical–chemical and thermal properties of these biocomposites were characterized. The residue can be used as a filler in compression-molded PHBV biocomposites. The most suitable formulation was 10 wt. %, despite the presence of some cassava bagasse (CB) agglomerations. This film could be used as rigid packaging for chilled or shelf-aqueous food. Full article

EV motors and machine elements operate at higher speeds, generate significant heat and noise (vibration), and subject lubricants (bearings) to multiple degrading factors, requiring thermal stability, wear protection, mitigating wear mechanisms like pitting and scuffing, and low electrical conductivity to prevent arcing damage to bearings. This study evaluates the tribological performance of four types of greases—PUEs, PUPao, PUEth (polyurea-based), and LiPAO (lithium–calcium complex-based)—to determine their suitability for electric motor bearings. Key performance metrics include tribological properties, electrical resistivity, leakage, bearing noise, and wear behavior. A four-ball wear test ranks the greases by scar diameter as PUPao < PUEs < PUEth < LiPAO, while the coefficient of friction is observed in the range of 0.15–0.18, with LiPAO exhibiting the lowest friction. Electrical resistivity tests reveal that PUEs grease has the lowest resistivity. Electrical leakage tests, conducted with a voltage differential across bearings, assess pitting damage, with PUEth and LiPAO showing evidence of surface pitting. Optical microscopy and scanning electron microscopy analysis is carried out to examine the pitting. In bearing noise tests, PUEs demonstrates the lowest noise levels, whereas LiPAO produces the highest. Visual and microscopic examination of the greases further characterizes their lubricating properties. Based on overall performance, the greases are ranked in suitability for electric motor applications as PUEs > PUPao > PUEth > LiPAO. The findings highlight the critical need for selecting appropriate grease formulations to ensure optimal bearing performance under varying operational conditions. Full article

In the manufacture of infant formulas, from raw materials to the final product, the ingredients are subject to high temperatures which favor the formation of undesirable compounds, some of them from the Maillard reaction, such as 5-hydroxymethylfurfural (HMF) and acrylamide, and others from thermal processing, such as the compound 3-monochloro-1,2-propanoldiol (3-MCPD). Finally, there is also a risk that the product may be adulterated with undesirable components such as melamine and cyanuric acid. Due to the vulnerability of infants during the first stage of life, this review answers the main question: How much of these undesirable compounds are present in commercial infant formulas, and what do we know about them? Accordingly, the review is divided into three sections: (1) Maillard reaction products (HMF and acrylamide), (2) products contained in vegetable oils (3-MCPD), and (3) fraudulent and/or adulterant compounds (melamine and cyanuric acid). The objective is to report on the occurrence of HMF, acrylamide, 3-MCPD, melamine, and cyanuric acid in infant formulas in order to support more solid public health policies related to infant feeding. These undesirable compounds represent a risk to infants, possibly contributing to kidney and neurological damage and causing mutations that increase the development of childhood cancer. Therefore, it is necessary to promote breastfeeding and establish stricter controls, with scientific evidence on the effects of HMF, acrylamide, 3-MCPD, melamine, and cyanuric acid in infant formulas to reduce their short- and long-term effects on infants’ health. Full article

This paper examines the splitting tensile properties of rubberized polyethylene-engineered cementitious composites (RPECC) through static and dynamic experimental tests, highlighting the effects of thermal cycles, impact strain rates, and rubber powder substitution rates for fine aggregates. Damage patterns, ultimate tensile strength, time-dependent stress curves, dynamic failure strain, and the dynamic increase factor of the RPECC are presented. The microstructure of the material is analyzed using scanning electron microscopy and energy-dispersive X-ray spectroscopy. Experimental results reveal that incorporating rubber powders significantly enhances the deformability and ductility of RPECC in splitting tension. However, a high content of rubber powders, such as a substitution percentage of 30%, significantly reduces static and the dynamic ultimate tensile strength of the RPECC by 16.8% and 34.2%, respectively. Microstructural examinations indicate that thermal cycling weakens the internal adhesion between the rubber particles, polyethylene fibers, and the ECC matrix, resulting in the frequent withdrawal of fibers and the formation of calcium hydroxide, which diminishes the material tensile strength by up to 20.6% in static tests and 45.1% in dynamic tests. Despite these challenges, the RPECC with 20% rubber achieves a favorable balance between splitting the tensile properties and thermal resistance, even after undergoing 270 heat-cool cycles, suggesting its potential applicability in harsh environments. Full article

Background: In thermal injuries, enzymatic debridement is a viable option for treating partial- and full-thickness burns, allowing for rapid removal of damaged tissue with minimal bleeding and without sacrificing healthy dermis. Enzymatic debridement using Nexobrid^® combined with negative wound pressure therapy (NWPT) appears to promote healing, as enzymatic debridement helps preserve healthy tissue integrity and epithelial reserves. We explored therapeutic alternatives following enzymatic debridement to assess healing outcomes and reduce reliance on skin grafts. Methods: 24 patients with deep or partially deep thermal burns on 5–40% of total body surface area (TBSA) underwent enzymatic debridement; then, half received NWPT and the other half were treated with topicals. Results: Enzymatic debridement effectively removed necrotic tissue and facilitated healing. Only three patients required skin grafts (<10% TBSA). Enzymatic debridement combined with NWPT expedited daily healing, reduced hospitalization days, and eliminated wound secretion, as confirmed by bacteriological examination. This approach was more effective compared to enzymatic debridement followed by topical treatments. Conclusions: Nexobrid^® in combination with NWPT is a promising alternative to surgical treatment, improving healing, reducing the need for skin grafts, and alleviating pain associated with dressing changes. It may be particularly useful in extensive burns, where epithelial reserves are limited. Full article

Gasification of lignocellulosic biomass has been widely highlighted as one of the most robust and promising low-carb approaches toward sustainable energy production. The gasification syngas obtained from agro-industrial residues can produce heat, power, biohydrogen, and other drop-in biofuels via F-T (Fischer-Tropsch) synthesis. However, the tar formation during the thermochemical process imposes severe limitations on the commercial scale of this technology. Tar elimination is a critical step for avoiding damage to equipment and not restricting the further application of syngas. In this context, this work sheds light on the biomass gasification field and reviews some aspects of tar formation and technologies for its reduction and removal. The approaches for dealing with tar are primary methods, which suppress or remove tar within the gasifier, and secondary methods, which remove tar in post-operation treatment. Catalytic reforming offers the most cost-effective pathway to removing tar. The bimetallic combination of nickel with other metals and using biochar as support have been intensely investigated, showing excellent tar conversion capacity. Recent research has provided new trends in non-thermal plasma-catalyzed biomass tar reforming. Future studies should focus on the integration of catalysts with multiple techniques to improve efficiency and reduce energy consumption. Full article

Introduction: Rheumatoid arthritis (RA) is a systemic inflammatory and autoimmune disease characterized by joint swelling, pain, damage to the cartilage, and disability. In the present study, we aimed to evaluate the anti-oxidant, anti-inflammatory, and immune-modulatory properties of Quantum Health Accelerator^® as water enriched with vital bio-quantum information/energy (EW) following complete Freund’s adjuvant (CFA)-induced RA in rats. Methods: Forty adult male Wistar rats (180–220 g) were divided into five groups. Arthritis was induced on day one using a single subcutaneous injection of CFA into the left hind footpad of the rat. Rats were assigned to receive methotrexate (MTX, 2 mg/kg/week, intraperitoneally), EW (orally, instead of normal water ad libitum), or their combination for 29 days. The anti-RA activities were determined by paw edema, joint diameter, arthritis score, and several nociceptive behavioral tests (thermal hyperalgesia, cold allodynia, and tactile allodynia). The levels of inflammatory (TNF-α, CRP, RF, and anti-CCP), anti-inflammatory (IL-10), and oxidative stress (NO, MDA, and GSH) markers were measured in serum. In addition, the levels of IFN-γ, IL-4, IL-17, and TGF-β were assessed in the spleen-isolated lymphocytes. Results: We found that treatment with MTX, EW, and their combination remarkably ameliorated thermal hyperalgesia, cold allodynia, and tactile allodynia results following CFA-induced RA in rats. In addition, EW also notably attenuated arthritis score, joint diameter, inflammatory cytokines, and oxidative markers while propagating anti-inflammatory and anti-oxidative mediators. Conclusions: We reveal that EW possesses anti-arthritic effects, possibly through anti-oxidative, anti-inflammatory, and immunomodulatory properties. Collectively, EW may be a promising therapeutic agent for treating RA. Full article

The increasing power density of high-performance electronic devices poses significant thermal management challenges. Vapor chambers (VCs) offer efficient heat dissipation, but traditional manufacturing methods limit their structural precision and performance. This study investigates the thermal performance of VCs fabricated with additive manufacturing (AM), featuring triply periodic minimal surface (TPMS) Gyroid capillary structures at two fill ratios under varying thermal loads. Enhanced thermal stability and performance were observed in the higher fill ratio, particularly under higher heat loads, whereas the lower fill ratio excelled under low-heat conditions, achieving a thermal resistance as low as 0.3688 K/W at an 80 W heat load. Additionally, the research explored the advantages and challenges of horizontal and vertical printing techniques in VC fabrication. Horizontal printing was found to compromise cavity volume due to necessary support structures, whereas vertical printing enhanced mass production feasibility and maintained effective vapor circulation. This study proposes a novel approach using AM to manufacture VCs as a monolithic structure. By eliminating the need for welding, this method ensures seamless integration of the capillary structure with the housing, thereby avoiding issues related to poor contact or welding-induced damage. The study confirmed a 75% reduction in thermal resistance in VCs with capillary structures compared to those without under similar conditions, highlighting the significant potential of integrating precisely designed capillary structures and additive manufacturing in improving vapor chamber performance for advanced thermal management applications. Full article

The use of femtosecond laser for bone ablation has been demonstrated in numerous studies; however, the clinical application requires further optimization to meet safety, accuracy, and efficiency standards. This study aims to optimize the energy density parameter of a robot-controlled femtosecond laser surgical system for bone ablation by assessing temperature changes, ablation efficiency, and ablation effects. Furthermore, the morphological and histological characteristics of bone tissue were compared with those of conventional mechanical methods. The results indicated that a laser energy density of 1.05 J/cm² was optimal for bone ablation, maintaining the bone surface temperature below 47 °C and achieving an ablation efficiency of 0.145 mm³/s. The deviations in cavity diameters were significantly smaller for the laser group (6.58 ± 18.09 μm) compared to the bur group (80.09 ± 45.45 μm, p < 0.001, N = 5 per group). Femtosecond laser ablation produced cleaner cavity margins with minimal bone debris accumulation. Additionally, the adjacent Volkmann and Haversian canals retained their normal morphology, indicating limited mechanical and thermal damage to the bone tissue. The robot-controlled femtosecond laser system demonstrated the potential for achieving safe, accurate, efficient, and clean bone ablation, offering promising prospects for clinical applications. Full article

This study aimed to develop a novel Transdermal Energy Transmission System (TETS) device that addresses the driveline complications faced by patients with advanced heart failure (HF). Our TETS device utilizes a two-channel configuration with a very-low duty cycle and a pulsed RF power transmission technique, along with elliptically shaped flexible coil inductive coupling elements. We integrated a battery charging controller module into the TETS, enabling it to recharge an implanted Lithium-Ion (Li-Ion) battery that powers low-power-rated Circulatory Assist Devices, or left ventricular assist devices (LVADs). Benchtop measurements demonstrated that the TETS delivered energy from the implanted coils to the battery charging module, at a charging rate of up to 2900 J/h, presented an average temperature increase (ΔT) of 3 °C. We conducted in vivo measurements using four porcine models followed by histopathological analysis of the skin tissue in the implanted coils areas. The thermal profile analysis from the in vivo measurements and the calculated charging rates from the current and voltage waveforms, in porcine models, indicated that the charging rate and temperature varied for each model. The maximum energy charging rate observed was 2200 J/h, with an average ΔT of 3 °C. The exposed skin tissue histopathological analysis results showed no evidence of tissue thermal damage in the in vivo measurements. These results demonstrate the feasibility of our developed TETS device for wireless driving implanted low-power-rated LVADs and Li-Ion charging. Full article