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14 pages, 232 KiB  
Article
Awareness and Attitudes of the Saudi Population Towards Bariatric Surgery in Saudi Arabia
by Baraa Alghalyini, Abdul Rehman Zia Zaidi, Zainudheen Faroog, Mohamad Aljejakli, Najib Fares Garad, Muaadh Shariff Muhammad Nyroze, Muhammad Usaid Ejaz, Mustafa Khedr, Mohamed Yousif, MSM Abrar Fuad Khan and Abdulghaffar Khateeb
Healthcare 2024, 12(24), 2528; https://doi.org/10.3390/healthcare12242528 - 13 Dec 2024
Viewed by 421
Abstract
Background: Obesity is a growing public health concern worldwide, and Saudi Arabia faces rising rates of obesity-related conditions, including diabetes and cardiovascular diseases. Bariatric surgery is a recognized treatment for severe obesity, offering significant health benefits. This study evaluates the Saudi population’s [...] Read more.
Background: Obesity is a growing public health concern worldwide, and Saudi Arabia faces rising rates of obesity-related conditions, including diabetes and cardiovascular diseases. Bariatric surgery is a recognized treatment for severe obesity, offering significant health benefits. This study evaluates the Saudi population’s awareness and attitudes towards bariatric surgery, examining knowledge levels, perceptions, and potential barriers. Methods: A cross-sectional survey was conducted among adults in Riyadh using convenience and snowball sampling. The survey included demographic data, awareness of obesity and bariatric surgery, attitudes towards the procedure, perceived barriers, and willingness to consider surgery. Data were analyzed using descriptive statistics and logistic regression. Results: Among 313 participants (mean BMI 26.98 kg/m2), 41.9% identified obesity as a disease, and 48.9% recognized the effectiveness of bariatric surgery for severe obesity. Knowledge scores averaged 4.08 (out of 5) for obesity and 3.28 (out of 6) for bariatric surgery. Significant associations were found between bariatric surgery knowledge and gender (p < 0.001), BMI (p = 0.004), income (p = 0.025), and educational level (p = 0.001). While 71.2% would not consider surgery, misconceptions about risks, stigma, and cost remain common barriers. Conclusions: Although awareness of bariatric surgery in Saudi Arabia is moderate, misconceptions about safety and financial constraints persist. Public education campaigns are necessary to dispel myths, improve understanding, and promote bariatric surgery as a viable treatment option for severe obesity. Expanding insurance coverage and financial support may also enhance accessibility and adoption of this life-saving intervention. Full article
18 pages, 2280 KiB  
Article
Introducing a Breakthrough Constant Pressure System: Transforming the Measurement of Clogging Potential in Wine Filtration
by Luis Lillo Otarola, Hanns de la Fuente-Mella and José Ceroni-Díaz
Appl. Sci. 2024, 14(24), 11640; https://doi.org/10.3390/app142411640 - 13 Dec 2024
Viewed by 561
Abstract
The wine industry uses filtration systems to remove particles that could compromise the quality of wine before bottling. However, traditional systems present significant operational limitations, such as volume restrictions, intensive handling, and risks associated with high-pressure devices. This study addresses these challenges by [...] Read more.
The wine industry uses filtration systems to remove particles that could compromise the quality of wine before bottling. However, traditional systems present significant operational limitations, such as volume restrictions, intensive handling, and risks associated with high-pressure devices. This study addresses these challenges by proposing an innovative solution: a pneumatic pumping system that delivers a pulsed flow under constant pressure, replacing conventional pressurized tanks for clogging tests. This approach not only reduces analysis time by 66.2% but also improves operational safety and enables the development of new indicators that are not limited by tank volume. To validate this proposal, a robust methodological framework was developed, integrating techniques and methodologies typically addressed separately into a single comprehensive approach. This includes evaluating the reproducibility of measurements, performing a comparative analysis of hydraulic performance under standard conditions, quantifying the impact on processing times, and assessing user perceptions. This approach demonstrates that the proposed device contributes to faster operational decision-making without exposing workers to unnecessary risks while optimizing resource usage. It addresses a previously underexplored technical challenge and establishes a solid foundation for future research, highlighting its academic relevance and impact beyond a technical implementation. Full article
(This article belongs to the Section Applied Industrial Technologies)
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<p>Relationship between time and filtered volume, highlighting the values used for the calculation of Vmax, FI, and FMI.</p>
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<p>Parts and components of the system based on the use of a pressure tank.</p>
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<p>Diagram of components of the proposed system based on the use of a pneumatic pumping system with constant pressure.</p>
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<p>Functional prototype of the proposed system.</p>
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<p>Graphical interface used for data capture.</p>
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<p>Result of the average times measured at each stage of the measurement process.</p>
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<p>Result of the user survey.</p>
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15 pages, 528 KiB  
Article
The Risk of Disordered Eating in Fitness Club Members—A Cross-Sectional Study
by Christina Gjestvang, Therese F. Mathisen, Solfrid Bratland-Sanda and Lene A. H. Haakstad
Sports 2024, 12(12), 343; https://doi.org/10.3390/sports12120343 - 12 Dec 2024
Viewed by 562
Abstract
Fitness clubs may be environments where abnormal eating behaviors and excessive exercise are socially accepted, potentially putting individuals at risk for disordered eating (DE). This study examined the DE risk prevalence among gym members, comparing body appreciation, exercise motivation, frequency, BMI, and age [...] Read more.
Fitness clubs may be environments where abnormal eating behaviors and excessive exercise are socially accepted, potentially putting individuals at risk for disordered eating (DE). This study examined the DE risk prevalence among gym members, comparing body appreciation, exercise motivation, frequency, BMI, and age across DE risk levels, and assessed the associated factors. A sample of 232 gym members (age: 39.6 ± 13.7) completed an online survey measuring DE risk (Eating Disorder Screen for Primary Care (ESP)), body appreciation (Body Appreciation Scale version 2), and exercise motivation (Behavioral Regulation in Exercise Questionnaire-2). One out of five (19.4%) were at risk of DE, while 15.5% and 11.6% reported having secretive eating behaviors and a history of eating disorders, respectively. Body weight impacted self-perception for 62.5% of the respondents. Those at DE risk had a higher mean BMI (26.23 ± 4.36 vs. 24.68 ± 3.61, p = 0.032) with a higher proportion of those with a BMI of 25–29.9 (46.67% vs. 29.41%, p = 0.027) compared to non-at-risk individuals. DE risk was associated with lower body appreciation (3.00 ± 3.60 versus 4.00 ± 3.70, p = ≤0.001), with body appreciation being the only factor associated with DE risk (OR = 0.24, 95% CI = 0.15, 0.39, p = ≤0.001). Full article
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<p>Flowchart of the participants.</p>
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20 pages, 1842 KiB  
Article
Assessment and Management of Risks from Occupational Exposure to Electromagnetic Fields (0 Hz to 300 GHz): A Compass to Keep the Right Course Through European and Italian Regulations
by Laura Filosa and Vanni Lopresto
Safety 2024, 10(4), 104; https://doi.org/10.3390/safety10040104 - 12 Dec 2024
Viewed by 542
Abstract
This paper outlines the specific provisions of Italian legislation regarding workers’ exposure to electromagnetic fields (EMFs) from 0 Hz to 300 GHz compared to the minimum health and safety requirements set in European Directive 2013/35/EU. In particular, the path to be followed to [...] Read more.
This paper outlines the specific provisions of Italian legislation regarding workers’ exposure to electromagnetic fields (EMFs) from 0 Hz to 300 GHz compared to the minimum health and safety requirements set in European Directive 2013/35/EU. In particular, the path to be followed to assess and manage occupational exposure to EMFs is outlined in relation to the distinction between ‘professional’ and ‘non-professional’ exposure of workers, as well as to the precautionary limits regarding exposures from power lines (50 Hz) and broadcast and telecommunication fixed systems (100 kHz–300 GHz) established by Italian regulations. The reasons underlying such an approach—mainly relying on the intent to reconcile scientific evidence with risk perception in public opinion—are analysed and discussed with the aim of increasing the knowledge of national regulatory provisions on occupational risk assessment, which may be more stringent than the requirements envisaged by international guidelines and community regulations. Full article
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<p>Italian regulatory framework regarding the protection of workers and the general public from EMF exposures.</p>
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<p>Flowchart of the EMF exposure assessment process under the Italian regulatory framework. Note—PL: power lines at grid frequency (50 Hz); BTFS: broadcast and telecommunication fixed systems (100 kHz–300 GHz).</p>
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<p>Zoning of the workplace as defined by CEI 106-45 for power lines at 50 Hz [<a href="#B29-safety-10-00104" class="html-bibr">29</a>].</p>
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<p>Zoning of the workplace as defined by CEI 106-45 for BTFS (100 kHz–300 GHz) [<a href="#B29-safety-10-00104" class="html-bibr">29</a>].</p>
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21 pages, 1232 KiB  
Article
Vaccine Acceptance Among Pregnant Women in Israel During COVID-19: Influences and Decision-Making Factors
by Noa Feldman, Michal Bitan, Maya Alayev and Orna Tal
Vaccines 2024, 12(12), 1404; https://doi.org/10.3390/vaccines12121404 - 12 Dec 2024
Viewed by 352
Abstract
Background and Objectives: In response to the COVID-19 pandemic, Israel prioritized pregnant women for vaccination, recognizing them as a high-risk group. This study aims to explore factors influencing the acceptance of Influenza, Pertussis (T-dap), and COVID-19 vaccines among pregnant women, focusing on attitudes, [...] Read more.
Background and Objectives: In response to the COVID-19 pandemic, Israel prioritized pregnant women for vaccination, recognizing them as a high-risk group. This study aims to explore factors influencing the acceptance of Influenza, Pertussis (T-dap), and COVID-19 vaccines among pregnant women, focusing on attitudes, social norms, perceived control, and risk perceptions. Additionally, the study compares acceptance patterns between traditional vaccines and the newer COVID-19 vaccine. Methods: A prospective cohort study was conducted between December 2019 and December 2021 involving 449 predominantly Israeli pregnant women. A survey was administered to gather data on demographics, obstetric history, vaccination history, and factors influencing vaccination decisions. Results: COVID-19 vaccine uptake was the highest at 64% (202/314), followed by T-dap at 49% (221/449) and Influenza at 32% (146/449). Multivariable logistic regression showed that non-religious women and those with academic education were more likely to accept vaccines, especially the COVID-19 vaccine. Physician recommendations were the most influential factor in vaccine acceptance, while internet and media sources played a significant role in shaping COVID-19 vaccine decisions. Perceived risks varied: Whooping Cough was seen as the greatest threat to newborns, while COVID-19 posed the highest risk to mothers. Analyzing maternal and neonatal disease perception using multivariable linear regression, we found that information on maternal and neonatal Flu, Whooping Cough, and COVID-19 was significantly positively correlated with disease perception for each condition. Conclusions: Healthcare providers play a crucial role in influencing vaccine decisions, especially through personalized communication. Strategies targeting religious communities and leveraging media can help address vaccine hesitancy, ultimately improving maternal and neonatal health outcomes. Full article
(This article belongs to the Section Human Vaccines and Public Health)
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<p>Comparison of the relative impact of professional (doctors, nurses, medical articles) and informal (internet, friends, media, personal experiences) sources on vaccination decisions.</p>
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<p>Impact of perceived disease risk to mother and fetus/newborn on vaccine acceptance across three vaccine types.</p>
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19 pages, 761 KiB  
Article
Understanding Perceptions of Hepatitis C and Its Management Among People with Experience of Incarceration in Quebec, Canada: A Qualitative Study Guided by the Common Sense Self-Regulation Model
by Andrea Mambro, Sameh Mortazhejri, David Ortiz-Paredes, Andrea Patey, Guillaume Fontaine, Camille Dussault, Joseph Cox, Jeremy M. Grimshaw, Justin Presseau and Nadine Kronfli
Viruses 2024, 16(12), 1910; https://doi.org/10.3390/v16121910 - 12 Dec 2024
Viewed by 499
Abstract
Hepatitis C virus (HCV) disproportionately affects certain sub-populations, including people with experience of incarceration (PWEI). Little is known about how perceptions of HCV and treatment have changed despite simplifications in testing and treatment in carceral settings. Nineteen semi-structured interviews were conducted with people [...] Read more.
Hepatitis C virus (HCV) disproportionately affects certain sub-populations, including people with experience of incarceration (PWEI). Little is known about how perceptions of HCV and treatment have changed despite simplifications in testing and treatment in carceral settings. Nineteen semi-structured interviews were conducted with people living with or having a history of HCV infection released from Quebec provincial prison. Interviews were guided by the Common Sense Self-Regulation Model (CS-SRM) and aimed to explore cognitive and emotional representations of HCV and coping strategies. Among the 19 participants, seven (37%) were diagnosed with HCV in prison and 14 (74%) had previously received HCV treatment. Participants’ HCV illness perceptions were influenced by fear (of HCV transmission, death, and the well-being of family) and stigma (related to HCV, injection drug use, and incarceration). While some sought education and social and professional support, others self-isolated or engaged in high-risk behaviors to cope. Despite advances in HCV treatment, PWEI continue to experience various forms of stigma and fear surrounding their HCV diagnosis, resulting in delayed HCV care. These findings provide insights into how prison-based healthcare providers can better utilize HCV illness perceptions to evaluate willingness to engage in HCV care among PWEI. Full article
(This article belongs to the Special Issue Hepatitis C Virus Infection among People Who Inject Drugs)
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<p>The Common Sense Self-Regulation Model (CS-SRM), adapted from Hagger and Orbell (2022).</p>
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25 pages, 634 KiB  
Article
Social Acceptance of Integrated Photovoltaic Systems in Italian Heritage and Landscape Contexts
by Dario Bottino-Leone, Agnieszka Elzbieta Stawinoga, Jennifer Adami, Alexandra Troi and Daniel Herrera-Avellanosa
Buildings 2024, 14(12), 3948; https://doi.org/10.3390/buildings14123948 - 12 Dec 2024
Viewed by 365
Abstract
This study investigates the social acceptance of integrated photovoltaic (IPV) systems in heritage and landscape contexts, focusing on Italian stakeholders in the construction sector. As part of the “BIPV meets History” research project, this study aims to identify barriers, potentials, drivers, and challenges [...] Read more.
This study investigates the social acceptance of integrated photovoltaic (IPV) systems in heritage and landscape contexts, focusing on Italian stakeholders in the construction sector. As part of the “BIPV meets History” research project, this study aims to identify barriers, potentials, drivers, and challenges for widespread PV technology adoption, considering heritage conservation, land preservation, energy production, and climate mitigation. A survey exploring opinions on PV technology integration was conducted. The survey was improved and extended to a total of 271 respondents, using the online method of Computer-Aided Web Interviewing (CAWI), to understand how perceptions of integrated photovoltaics have changed after COVID-19 and the European energy crisis, emphasizing aesthetic, environmental, economic, and personal aspects. The results indicate a general awareness of the technologies, with increasing acceptance in protected contexts, for historic buildings (from 51 to 68%) and especially landscapes (from 44 to 71%), driven by energy and environmental benefits. Cultural concerns, particularly the risk of impacting historical and natural identities, emerge as major barriers. Additionally, it is evident that awareness of PV panel recycling methods is still limited. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
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<p>Part 6 results: keywords selected by participants to identify integrated PV Systems on historic buildings and protected landscapes.</p>
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<p>General acceptance of integrated PV systems on historic buildings and protected landscapes for the respondents (Parts 3 and 4).</p>
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13 pages, 290 KiB  
Article
Are Foods with Protein Claims Healthy? A Study of the Spanish Market
by Marta Beltrá, Fernando Borrás and Ana B. Ropero
Nutrients 2024, 16(24), 4281; https://doi.org/10.3390/nu16244281 - 11 Dec 2024
Viewed by 371
Abstract
Background: Foods with protein claims (PCs) targeted at the general population are increasingly sought after by consumers because they think they are healthy. However, they may contain other nutrients that pose a health risk. Objectives: Therefore, the aim of this work was to [...] Read more.
Background: Foods with protein claims (PCs) targeted at the general population are increasingly sought after by consumers because they think they are healthy. However, they may contain other nutrients that pose a health risk. Objectives: Therefore, the aim of this work was to carry out a comprehensive evaluation of foods with PC and compare them with those without these claims. Methods: The Spanish Food Database, BADALI, was used for this purpose. We studied 4325 processed foods of 12 different types. Thirteen percent had PCs and more than half of them were fortified with proteins (60.4%). Plant proteins were added more frequently than animal proteins. Protein values were higher in foods with PCs, particularly in those that were fortified. Differences in other nutrients were also observed depending on the food type. The healthiness of foods was assessed using the Pan American Health Organization Nutrient Profile Model and 90.8% of those bearing PCs were classified as “less healthy”. More than 50% were high in fat or high in sodium; around one in four were high in free sugar or saturated fat and one in five had sweeteners. Foods with PCs had 13.1% more “less healthy” items than those without PCs. The proportion of items high in fat or high in sodium were also larger and more of them had sweeteners. In contrast, the proportion of foods high in free sugar and high in saturated fat was lower among those with PCs. Conclusions: Therefore, the perception that foods with PCs are healthy is incorrect, and consuming them may pose an additional health risk. Full article
(This article belongs to the Special Issue Nutrient Composition and Nutrition/Health-Related Claims)
9 pages, 264 KiB  
Article
Fear of Childbirth Among Pregnant People Facing Anti-Fat Bias
by Lee Roosevelt, Sarah Maguire, Akshay Sharma and Ruth Zielinski
Int. J. Environ. Res. Public Health 2024, 21(12), 1657; https://doi.org/10.3390/ijerph21121657 - 11 Dec 2024
Viewed by 413
Abstract
Explicit and implicit anti-fat biases are widespread among healthcare providers, leading to significant negative consequences for pregnant people, including poorer health outcomes. Fear of childbirth (FOC) can affect the length of labor, increase the risk of cesarean delivery, and negatively influence a new [...] Read more.
Explicit and implicit anti-fat biases are widespread among healthcare providers, leading to significant negative consequences for pregnant people, including poorer health outcomes. Fear of childbirth (FOC) can affect the length of labor, increase the risk of cesarean delivery, and negatively influence a new parent’s perception of infant bonding. This study investigated the impact of perceived anti-fat bias on FOC among pregnant people. Data were gathered from 329 pregnant people recruited from three large academic prenatal centers in the United States and via social media. Participants completed a survey that included validated instruments measuring perceptions of anti-fat bias and FOC. Participants perceiving anti-fat bias reported higher FOC. Black participants perceiving anti-fat bias reported higher FOC. These findings suggest that perceived anti-fat bias from providers is associated with FOC for pregnant people, particularly those who identify as Black. Interventions to educate providers on these important concepts could help improve pregnant people’s experience within the healthcare system. Full article
14 pages, 585 KiB  
Article
Assessing Quality of Life with the Novel QLQ-CAX24 Questionnaire and Body Composition Parameters in Rectal Cancer Patients: A Single-Center Prospective Study
by Marco Cintoni, Marta Palombaro, Pauline Raoul, Giuditta Chiloiro, Angela Romano, Elisa Meldolesi, Flavia De Giacomo, Elena Leonardi, Gabriele Egidi, Futura Grassi, Gabriele Pulcini, Emanuele Rinninella, Esmeralda Capristo, Antonio Gasbarrini, Maria Antonietta Gambacorta and Maria Cristina Mele
Nutrients 2024, 16(24), 4277; https://doi.org/10.3390/nu16244277 - 11 Dec 2024
Viewed by 330
Abstract
Background: Patients with rectal cancer (RC) are at risk of developing cancer-related cachexia, a complex metabolic syndrome that can negatively impact quality of life (QoL), treatment tolerance, and clinical response. Objectives: The aim of the study was to explore the possible associations of [...] Read more.
Background: Patients with rectal cancer (RC) are at risk of developing cancer-related cachexia, a complex metabolic syndrome that can negatively impact quality of life (QoL), treatment tolerance, and clinical response. Objectives: The aim of the study was to explore the possible associations of the novel European Organization for Research and Treatment of Cancer QoL Questionnaire—Cancer Cachexia (EORTC QLQ-CAX24) scores with body composition parameters and physical performance in patients with locally advanced RC (LARC). Methods: This prospective observational study involved RC patients evaluated at the dedicated outpatient clinic of Clinical Nutrition at the Fondazione Policlinico Agostino Gemelli IRCCS. Patients with a confirmed diagnosis of LARC were enrolled between January and December 2023. The body composition parameters were measured using the preoperative computed tomography scan at the level of the third lumbar vertebra as well as using bioimpedance analysis before and after the radiotherapy treatment. QoL was measured by the EORTC QLQ-C30 and EORTC QLQ-CAX24 questionnaires. Results: A total of 56 RC patients were enrolled. Significant associations (p < 0.05) were found between EORTC QLQ-CAX24 values and the presence of cachexia, body composition, handgrip strength, and malnutrition diagnosis. Muscle mass was significatively also associated with EORTC QLQ-CAX24 results, suggesting a link between subjective perception of QoL and objectively measured body composition. Conclusions: The EORTC CAX24 questionnaire can be an effective tool for monitoring changes in cachexia status during radiotherapy, enabling early detection of cachexia-related complications and timely intervention. Full article
(This article belongs to the Special Issue Body Composition and Nutritional Status in Cancer Patients)
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<p>Variations in QLQ-CAX24 mean scores before and after the completion of radiotherapy. Abbreviations: FA-LT, food aversion; EWLW-LT, eating and weight loss worry; ED-LT, eating difficulties; LC-LT, loss of control; PD-LT, physical decline; DM-LT, dry mouth; I-LT, indigestion and Heartburn; FTE-LT, forcing self to eat; Inf-LT, adequate information about weight loss.</p>
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17 pages, 5855 KiB  
Article
A Story of the ‘Kitchen Furniture’ in ECEC—Challenging Norms and Ideas Around Gender and Play
by Mia Heikkilä
Educ. Sci. 2024, 14(12), 1351; https://doi.org/10.3390/educsci14121351 - 10 Dec 2024
Viewed by 303
Abstract
The Swedish National Curriculum for Preschools states that “the environment in the preschool should inspire and challenge children to broaden their abilities and interests without being constrained by gender stereotyped perceptions”. The aim of a three-year research and development (R&D) project was to [...] Read more.
The Swedish National Curriculum for Preschools states that “the environment in the preschool should inspire and challenge children to broaden their abilities and interests without being constrained by gender stereotyped perceptions”. The aim of a three-year research and development (R&D) project was to both analyse and recreate early childhood education and care (ECEC) units’ indoor spaces, aiming at creating an indoor educational environment that would be socially inclusive and norm-aware, and support preschools to fulfil their curricular assignment around gender equality. The aim of this article is to present a specific process for challenging the norms around certain indoor play places and spaces as well as pieces of furniture in ECEC settings that risk reproducing gender norms. This aim was achieved through a social semiotic multimodal gender analysis of so-called “kitchen furniture”, as a well-established, commonly occurring space in ECEC. The process of how this was challenged is presented in this article. A gender analysis of what affordances for play this kitchen-focused piece of furniture gives, and how it can be recreated, was conducted. The introduction of more inclusive furniture to the ECEC units, through creating and building a play trolley, could affect children’s play in a more inclusive way. The analysis addressed both this idea and teachers’ self-initiated move of the piece of furniture within the ECEC unit. The process was performed with a multidimensional perspective of understanding play as a combination of children’s meaning-making and the affordances of both relationships and the environment. Full article
(This article belongs to the Special Issue Gender and Early Childhood Education: Debates and Current Challenges)
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<p>The kitchen furniture.</p>
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<p>The R&amp;D process work.</p>
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<p>Phases one and two of the R&amp;D process work.</p>
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<p>(<b>a</b>,<b>b</b>) The kitchen furniture in its original location.</p>
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<p>The play trolley.</p>
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<p>(<b>a</b>,<b>b</b>) The remodelled rooms.</p>
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19 pages, 2836 KiB  
Article
The Application of Machine Learning Techniques to Predict Stock Market Crises in Africa
by Muhammad Naeem, Hothefa Shaker Jassim and David Korsah
J. Risk Financial Manag. 2024, 17(12), 554; https://doi.org/10.3390/jrfm17120554 - 10 Dec 2024
Viewed by 478
Abstract
This study sought to ascertain a machine learning algorithm capable of predicting crises in the African stock market with the highest accuracy. Seven different machine-learning algorithms were employed on historical stock prices of the eight stock markets, three main sentiment indicators, and the [...] Read more.
This study sought to ascertain a machine learning algorithm capable of predicting crises in the African stock market with the highest accuracy. Seven different machine-learning algorithms were employed on historical stock prices of the eight stock markets, three main sentiment indicators, and the exchange rate of the respective countries’ currencies against the US dollar, each spanning from 1 May 2007 to 1 April 2023. It was revealed that extreme gradient boosting (XGBoost) emerged as the most effective way of predicting crises. Historical stock prices and exchange rates were found to be the most important features, exerting strong influences on stock market crises. Regarding the sentiment front, investors’ perceptions of possible volatility on the S&P 500 (Chicago Board Options Exchange (CBOE) VIX) and the Daily News Sentiment Index were identified as influential predictors. The study advances an understanding of market sentiment and emphasizes the importance of employing advanced computational techniques for risk management and market stability. Full article
(This article belongs to the Special Issue Investment Management in the Age of AI)
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<p>Model performance across countries. Source: the authors’ construct (2024).</p>
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<p>Receiver operating characteristic (ROC). Source: the authors’ construct (2024).</p>
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<p>Receiver operating characteristic (ROC). Source: the authors’ construct (2024).</p>
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<p>Feature importance. Source: the authors’ construct (2024).</p>
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21 pages, 4591 KiB  
Article
Impact of the COL1A1 Gene Polymorphisms on Pain Perception in Tennis Elbow Patients: A Two-Year Prospective Cohort Study
by Paweł Niemiec, Alicja Jarosz, Tomasz Nowak, Anna Balcerzyk-Matić, Tomasz Iwanicki, Joanna Iwanicka, Katarzyna Gawron, Marcin Kalita, Sylwia Górczyńska-Kosiorz, Wojciech Kania and Karol Szyluk
Int. J. Mol. Sci. 2024, 25(23), 13221; https://doi.org/10.3390/ijms252313221 - 9 Dec 2024
Viewed by 401
Abstract
The COL1A1 gene encodes the α1 chain of type I collagen, and the data reported so far demonstrate that its polymorphic variants may affect biomechanical properties of bones, muscles, and tendons, and contribute to musculoskeletal disorders. Given, however, limited research on these variants [...] Read more.
The COL1A1 gene encodes the α1 chain of type I collagen, and the data reported so far demonstrate that its polymorphic variants may affect biomechanical properties of bones, muscles, and tendons, and contribute to musculoskeletal disorders. Given, however, limited research on these variants in tendon pathology, we analyzed the impact of COL1A1 polymorphisms on the tendinopathy phenotype and the effectiveness of platelet-rich plasma (PRP) treatment for tennis elbow. Pain perception and therapy outcomes were analyzed from baseline, i.e., before PRP injection to two years post-PRP injection in a cohort of 107 patients. The study focused on seven COL1A1 variants: rs2249492 (C/T), rs2586488 (A/G), rs2075558 (A/C), rs2253369 (C/T), rs35231764 (A/G), rs1800012 (C/A), and rs9898186 (C/T). We demonstrated that carriers of the TT/CT (rs2249492), AA/AC (rs1800012), and TT/CT (rs9898186) genotypes reported pain related to injury more frequently than subjects with other COL1A1 variants, also in the context of performing specific activities and other pain characteristics. These polymorphisms did not significantly influence therapy effectiveness, although rs35231764 showed a moderate effect. In conclusion, the T (rs2249492), A (rs1800012), and T (rs9898186) alleles of COL1A1 gene are risk factors for pain perception in tennis elbow patients, but do not appear to substantially impact PRP treatment outcomes. Full article
(This article belongs to the Section Molecular Genetics and Genomics)
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<p>Crucial processes observed in tendinopathy (based on two figures from Servier Medical Art resource [<a href="#B13-ijms-25-13221" class="html-bibr">13</a>]: Tendon anatomy and Tendonitis, both licensed under CC BY 4.0., modified by P. Niemiec). Legend: ECM, extracellular matrix; MMPs, matrix metalloproteinases; VEGF, vascular endothelial growth factor.</p>
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<p>Location of the <span class="html-italic">COL1A1</span> gene single nucleotide polymorphisms (SNPs). The figure was created on the basis of data from LDmatrix Tool [<a href="#B50-ijms-25-13221" class="html-bibr">50</a>]. Legend: GRCh38, Genome Reference Consortium Human Build 38 Organism: <span class="html-italic">Homo sapiens</span>; SNPs, single nucleotide polymorphisms.</p>
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<p>Haplotype analysis of the <span class="html-italic">COL1A1</span> gene polymorphisms in the study group (<b>A</b>) and CEU population (<b>B</b>). The darker the color, the higher the D′ or R<sup>2</sup> values.</p>
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<p><span class="html-italic">COL1A1</span> gene expression in skeletal muscle tissue, depending on the genotypes of the rs2586488 and rs2253369 polymorphisms. Based on the data from GTEx Portal [<a href="#B51-ijms-25-13221" class="html-bibr">51</a>].</p>
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<p>Medians (±QD) of VAS and QDASH values in respect to genotype variants of the <span class="html-italic">COL1A1</span> gene rs35231764 polymorphism (recessive–dominant model). Legend: QD, quartile deviation; VAS, visual analog scale; QDASH, quick version of disabilities of the arm, shoulder and hand score; *, differences remaining significant after Hochberg correction for multiple comparisons (threshold of significance for recessive–dominant model: <span class="html-italic">p</span> ≤ 0.009).</p>
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<p>Achievement of minimal clinically important difference for VAS, QDASH and PRTEE in the context of respective polymorphic variants of the <span class="html-italic">COL1A1</span> gene: rs2249492 (<b>A</b>), rs2586488 (<b>B</b>), rs2075558 (<b>C</b>), rs2253369 (<b>D</b>), rs35231764 (<b>E</b>), and rs1800012 (<b>F</b>). Legend: PRTEE, Patient-Rated Tennis Elbow Evaluation; QD, Quartile Deviation; QDASH, quick version of Disabilities of the Arm, Shoulder and Hand score; VAS, Visual Analog Scale; *, differences remaining significant after Hochberg correction for multiple comparisons (threshold of significance for MCID analysis: <span class="html-italic">p</span> ≤ 0.022); §, differences significant (<span class="html-italic">p</span> &lt; 0.050) in multivariate logistic regression analysis (adjusted for all SNPs, age, sex, comorbidities and additional forms of therapy during follow-up).</p>
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<p>Pathophysiological mechanism for the adverse effects of the A allele (rs1800012) on the musculoskeletal system. Based on [<a href="#B25-ijms-25-13221" class="html-bibr">25</a>,<a href="#B37-ijms-25-13221" class="html-bibr">37</a>,<a href="#B38-ijms-25-13221" class="html-bibr">38</a>,<a href="#B39-ijms-25-13221" class="html-bibr">39</a>,<a href="#B40-ijms-25-13221" class="html-bibr">40</a>,<a href="#B41-ijms-25-13221" class="html-bibr">41</a>,<a href="#B42-ijms-25-13221" class="html-bibr">42</a>,<a href="#B43-ijms-25-13221" class="html-bibr">43</a>,<a href="#B52-ijms-25-13221" class="html-bibr">52</a>,<a href="#B55-ijms-25-13221" class="html-bibr">55</a>,<a href="#B56-ijms-25-13221" class="html-bibr">56</a>,<a href="#B57-ijms-25-13221" class="html-bibr">57</a>,<a href="#B58-ijms-25-13221" class="html-bibr">58</a>]. Description in the text.</p>
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<p>Flowchart of the study selection.</p>
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15 pages, 614 KiB  
Article
Nurses’ Clinical Practice in Nursing Homes: Depressive Symptoms and Fall Risk Assessment
by Alcina Matos Queirós, Armin von Gunten, Maria Manuela Martins and Henk Verloo
Geriatrics 2024, 9(6), 158; https://doi.org/10.3390/geriatrics9060158 - 9 Dec 2024
Viewed by 437
Abstract
Background: Depression and falls are highly prevalent, interrelated concerns for nursing home (NH) residents. Relationships between depression and falls should guide nurses towards developing evidence-based practices for assessing these conditions together. This study aimed to ascertain NH nurses’ clinical practices and perceptions regarding [...] Read more.
Background: Depression and falls are highly prevalent, interrelated concerns for nursing home (NH) residents. Relationships between depression and falls should guide nurses towards developing evidence-based practices for assessing these conditions together. This study aimed to ascertain NH nurses’ clinical practices and perceptions regarding the assessment of depression and fall risk. Methods: This study was an exploratory descriptive study on the reported practices and perceptions from NH nurses in the canton of Vaud, Western Switzerland. Statistical analyses included descriptive statistics, nonparametric tests and a content analysis of responses to open-ended questions. Results: The mean age of our 116 responding nurses was 44.6 years old (SD = 11.3), 99 were women and their mean work experience in NHs was 13.1 years (SD = 9.2). The reporting showed that 88.8% of nurses relied on mood observation for assessing depression and 88.8% relied on the history of falls to identify fall risk. Only 75.9% and 61.2% of nurses used validated scales to detect depression and fall risk, respectively. Additionally, 56.9% of participants considered depression to be a significant factor in fall risk. Conclusion: Validated tools to assess depression and fall risk in NHs should be used more widely. Health policies must support and enhance NH nurses’ training and skills. Full article
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<p>The survey variables explored by the comprehensive geriatric assessment and the Nursing Process approach—inspired by Spirgiene and Brent [<a href="#B21-geriatrics-09-00158" class="html-bibr">21</a>].</p>
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13 pages, 659 KiB  
Review
Polygenic Risk Score Implementation into Clinical Practice for Primary Prevention of Cardiometabolic Disease
by Julia Hughes, Mikayla Shymka, Trevor Ng, Jobanjit S. Phulka, Sina Safabakhsh and Zachary Laksman
Genes 2024, 15(12), 1581; https://doi.org/10.3390/genes15121581 - 9 Dec 2024
Viewed by 523
Abstract
Background: Cardiovascular disease is a leading cause of mortality globally and a major contributor to disability. Traditional risk factors, as initially established in the FRAMINGHAM study, have helped to stratify populations and identify patients for early intervention. Incorporating genetic factors enhances risk [...] Read more.
Background: Cardiovascular disease is a leading cause of mortality globally and a major contributor to disability. Traditional risk factors, as initially established in the FRAMINGHAM study, have helped to stratify populations and identify patients for early intervention. Incorporating genetic factors enhances risk stratification tools, enabling the earlier identification of individuals at increased risk and facilitating more targeted and effective risk factor modifications. While monogenic risk variants are present in a minority of the population, polygenic risk scores (PRS) are collections of multiple single-nucleotide variants that collectively provide summative risk and capture a more accurate risk score for a greater number of people. PRS have demonstrated clear utility in cardiometabolic diseases by predicting onset, progression, and therapeutic response. Methods: A structured and exploratory hybrid search strategy was employed, combining keyword-based database searches and supplementary techniques to comprehensively synthesize the literature on PRS implementation in clinical practice. Discussion: A comprehensive overview of PRS in cardiometabolic diseases and their potential avenues for integration into primary care is discussed. First, we examine the implementation of genetic screening, risk communication, and intervention strategies through the lens of the American Heart Association’s implementation criteria, focusing on their efficacy, minimization of harm, and logistical considerations. Then, we explores how the varied perceptions of patients and practitioners towards PRS can influence both adoption and utilization. Lastly, we addresses the need for the development of clear guidelines and regulations to support this process, ensuring PRS integration is both scientifically sound and ethically responsible. Future directions: Initiatives aimed at advancing personalized approaches to disease prevention will enhance health outcomes. Developing guidelines for the responsible use of PRS by establishing benefits, while mitigating risk, will a key factor in implementation for clinical utility. Conclusions: For integration into clinical practice, we must address both patient and provider concerns and experience. Standardized guidelines and training will help to effectively implement PRS into clinical practice. Developing these resources will be essential for PRS to fulfill its potential in personalized, patient-centered care. Full article
(This article belongs to the Section Human Genomics and Genetic Diseases)
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<p>Representation of each of the key stakeholders and their involvement in and influence on PRS implementation into clinical practice.</p>
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