Search Results (55,000)

Energy is regarded as a crucial facilitator of social and economic advancement, and, consequently, sustainable development. The concept of sustainable energy development has evolved to become a significant political objective addressed by governments worldwide. All sectors of the economy, including agriculture, require stimulation, which should be triggered by linkages and structural changes contributing to qualitative and quantitative progress. Agriculture has a substantial impact on the environmental footprint, playing a pivotal role in causing climate change. The objective of this article is to address the research gap concerning the monitoring of sustainable development in the energy and agricultural sectors within the European Union. The assessment of sustainability is a complex process since it is a multidisciplinary field of study with practical implications. The progress of sustainable development in the energy and agricultural sectors was evaluated through a comprehensive analysis of relevant literature and statistical data obtained from the Eurostat database and the Research Institute of Organic Agriculture FiBL. The analysis encompasses the period between 2015 and 2022. The article employs the taxonomic method, specifically the linear ordering method (standardised sum method), which enables the construction of a synthetic measure. This approach enabled the creation of rankings and comparisons between European Union countries. The studies show that in the European Union, sustainable energy development and sustainable agriculture show significant territorial differentiation. The sustainable energy measures in the countries with the highest scores (Estonia, Sweden, Finland, Austria) were 2–3 times higher than in the countries with the lowest scores (Cyprus, Belgium, Greece, Bulgaria). A similar situation was observed for sustainable agriculture measures—the maximum measures (Estonia, Bulgaria, Slovakia, Lithuania) were about two times higher than the minimum measures (Poland, Malta, Slovenia, Luxembourg). The findings indicate that, on the one hand, there have been favourable developments at the national level in Europe, but also that there are a number of existing disparities, together with evidence of potentially significant deviations from the targets set out in the 2030 Agenda. Full article

Regarding the carbon emission performance of urbanization, the changes in carbon emissions and carbon sinks have attracted particular attention, while the internal impact mechanism has been under-researched. Conventionally, urbanization has either improved or hindered carbon performance. However, this is not always the case as the paths of urbanization affecting carbon emission performance are diverse. Hence, this paper proposes a theoretical framework to investigate how urbanization influences carbon emission performance, specifically the indirect effects of land development/land-use efficiency, by taking the Yangtze River Delta urban agglomeration, China, as a study case. Empirical results show that urbanization improves carbon emission performance due to the agglomeration effect. As an intermediary pathway, land-use change has a two-sided impact on carbon emission performance. Urbanization can both worsen and improve carbon emission performance through increasing land-development intensity and promoting land-use efficiency, respectively. However, the positive impact of land-use efficiency can alleviate the problem of increasing carbon emissions caused by land over-development. Hence, the integration of urban planning strategies with land use management policies can help to achieve sustainable urbanization. Full article

Background/Objectives: Histamine intolerance is primarily caused by a deficiency in the diamine oxidase (DAO) enzyme at the intestinal level. The reduced histamine degradation in the gut leads to its accumulation in plasma, thereby causing multiple clinical manifestations, such as urticaria, diarrhea, headache, dyspnea, or tachycardia, among others. The dietary management of this food intolerance consists of the follow-up of a low-histamine diet, often combined with DAO supplementation. To date, around twenty studies have investigated the effectiveness of these dietary strategies in reducing the frequency and/or intensity of symptoms, with promising results. However, the limitations of these studies (small patient cohort, lack of control group, and short dietary intervention periods) highlight the need for more ambitiously designed research. Therefore, the main objective of this prospective, unicentric, double-blind, randomized, and placebo-controlled trial is to evaluate the efficacy of a low-histamine diet and/or DAO supplementation over a three-month period in improving symptoms of histamine intolerance. Additionally, the impacts of these dietary strategies on the intestinal microbiota composition, urinary profile of histamine metabolites, serum DAO activity, and plasma histamine levels will be assessed throughout the intervention. Methods: The trial will enroll 400 patients who will be randomly assigned to one of two groups: the intervention group, which will follow a low-histamine diet, or the control group, which will maintain their habitual dietary habits. Within each of these groups, participants will be further divided into four subgroups to receive either exogenous DAO enzyme supplementation (from porcine or plant sources, with the latter administered at two different dosages) or a placebo. Therefore, a total of eight distinct intervention groups will be considered. The comparison of these groups will allow the evaluation of the individual effects of the low-histamine diet or DAO enzyme supplementation, as well as their possible synergistic effect. Results: The results of this study should help to improve dietary recommendations for histamine-intolerant patients and ultimately enhance their quality of life. Full article

This study explores the potential of using underutilized materials from agricultural and forestry systems, such as rice husk, wheat straw, and wood strands, in developing corrugated core sandwich panels as a structural building material. By leveraging the unique properties of these biobased materials within a corrugated geometry, the research presents a novel approach to enhancing the structural performance of such underutilized biobased materials. These biobased materials were used in different lengths to consider the manufacturing feasibility of corrugated panels and the effect of fiber length on their structural performance. The average lengths for wood strands and wheat straws were 12–15 cm and 3–7.5 cm, respectively, while rice husks were like particles, about 7 mm long. Due to the high silica content in rice husk and wheat straw, which negatively impacts the bonding performance, polymeric diphenylmethane diisocyanate (pMDI), an effective adhesive for such materials, was used for the fabrication of corrugated panels. Wood strands and phenol formaldehyde (PF) adhesive were used to fabricate flat outer layers. Flat panels were bonded to both sides of the corrugated panels using a polyurethane adhesive to develop corrugated core sandwich panels. Four-point bending tests were conducted to evaluate the panel’s bending stiffness, load-carrying capacity, and failure modes. Results demonstrated that sandwich panels with wood strand corrugated cores exhibited the highest bending stiffness and load-bearing capacity, while those with wheat straw corrugated cores performed similarly. Rice husk corrugated core sandwich panels showed the lowest mechanical performance compared to other sandwich panels. Considering the applications of these sandwich panels as floor, wall, and roof sheathing, all these panels exhibited superior bending performance compared to 11.2 mm- and 17.42 mm-thick commercial OSB (oriented strand board) panels, which are commonly used as building materials. These sandwich structures supported a longer span than commercial OSB panels while satisfying the deflection limit of L/360. The findings suggest the transformative potential of converting renewable yet underutilized materials into an engineered concept, corrugated geometry, leading to the development of high-performance, carbon-negative building materials suitable for flooring and roof applications. Full article

Mycophenolic acid (MPA) is a commonly used immunosuppressant. In the human body, MPA is metabolized into mycophenolic acid 7-O-glucuronide (MPAG) and mycophenolic acid acyl-glucuronide (AcMPAG) mainly through liver glucuronidation, which involves UDP-glucuronosyltransferase (UGTs) and transfer proteins. Research has indicated that the pharmaceutical excipient PEG400 can impact drug processes in the body, potentially affecting the pharmacokinetics of MPA. Due to the narrow therapeutic window of MPA, combination therapy is often used, and PEG400 is widely used in pharmaceutical preparations. Therefore, investigating the pharmacokinetic influence of PEG400 on MPA could offer valuable insights for optimizing MPA’s clinical use. In this study, we examined the impact of a single oral dose of PEG400 on the blood levels of MPA in rats through pharmacokinetic analysis. We also investigated the distribution of MPA in various tissues using mass spectrometry imaging. We explored the potential mechanism by which PEG400 affects the metabolism of MPA using hepatic and intestinal microsomes and the Caco-2 cellular transporter model. Our findings reveal that the overall plasma concentrations of MPA were elevated in rats following the co-administration of PEG400, with the AUC_0-t of MPA and its metabolite MPAG increasing by 45.53% and 29.44%, respectively. Mass spectrometry imaging showed increased MPA content in tissues after PEG400 administration, with significant differences in the metabolites observed across different tissues. Microsomal and transport experiments showed that PEG400 accelerated the metabolism of MPA, promoted the uptake of MPA, and inhibited efflux. In conclusion, PEG400 alters the in vivo metabolism of MPA, potentially through the modulation of metabolic enzymes and transport. Full article

Exploring and predicting the spatiotemporal evolution characteristics and driving forces of carbon storage in typical mountain forest ecosystems under land-use changes is crucial for curbing the effects of climate change and fostering sustainable, eco-friendly growth. The existing literature provides important references for our related studies but further expansion and improvements are needed in some aspects. This study first proposed an integrated framework comprising gray multi-objective optimization (GMOP), Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST), the Patch-level Land Use Simulation Model (PLUS), and optimal parameter-based geographical detector (OPGD) models to further expand and improve on existing research. Then, the integrated model was used to analyze the spatial–temporal variation in land-use pattern and carbon storage at the county scale in China’s Daiyun Mountain’s Rim under four scenarios in 2032, and analyze the driving force of spatial differentiation of carbon storage. The results indicated that (1) land-use change primarily involves the mutual transfer among forest, cultivated, and construction land, with approximately 7.2% of the land-use type area undergoing a transition; (2) in 2032, the natural development scenario projects a significant reduction in forest land and an expansion of cultivated, shrub, and construction lands. Conversely, the economic priority, ecological priority, and economic–ecological coordinated scenarios all anticipate a decline in cultivated land area; (3) in 2032, the natural development scenario will see a 2.8 Tg drop in carbon stock compared to 2022. In contrast, the economic priority, ecological priority, and economic–ecological coordinated scenarios are expected to increase carbon storage by 0.29 Tg, 2.62 Tg, and 1.65 Tg, respectively; (4) the spatial differentiation of carbon storage is jointly influenced by various factors, with the annual mean temperature, night light index, elevation, slope, and population density being the key influencing factors. In addition, the influence of natural factors on carbon storage is diminishing, whereas the impact of socioeconomic factors is on the rise. This study deepened, to a certain extent, the research on spatiotemporal dynamics simulation of carbon storage and its driving mechanisms under land-use changes in mountainous forest ecosystems. The results can serve to provide scientific support for carbon balance management and climate adaptation strategies at the county scale while also offering case studies that can inform similar regions around the world. However, several limitations remain, as follows: the singularity of carbon density data, and the research scope being confined to small-scale mountainous forest ecosystems. Future studies could consider collecting continuous annual soil carbon density data and employing land-use simulation models (such as PLUS or CLUMondo) appropriate to the study area’s dimensions. Full article

This study investigates the optimization of boron coating parameters for medium-carbon steels, specifically AISI 1137, and their subsequent effects on mechanical properties, which are crucial for industrial applications. Despite extensive research on boronizing processes, an understanding of the optimal conditions that enhance wear resistance and hardness while maintaining structural integrity is still lacking. To address this gap, we systematically examined the impact of boronizing temperatures (850 °C and 950 °C) and durations (2, 4, and 8 h) on the structural and mechanical properties of AISI 1137 steel. Our findings indicate the need for improved surface properties in medium-carbon steels used in demanding environments, such as automotive and machinery components. The boronizing process was carried out using Ekabor 1 powder, with characterization performed through optical microscopy, pin-on-disk wear tests, and Vickers hardness analysis. Results showed that the thickness of the boronized layer ranged from 50.6 μm to 64.8 μm, with wear resistance increasing by 1.8 to 3.9 times at 950 °C compared to at 850 °C. The measured hardness of the boronized surface layers varied between 1963.7 HV and 219.3 HV, decreasing from the boronized layer toward the base material. The optimal parameters for wear resistance and hardness were found to be a temperature of 950 °C and a duration of 8 h, facilitating the formation of FeB and Fe₂B phases, which significantly enhanced the steel’s mechanical properties. This research provides valuable insights into the boronizing process and establishes a foundation for the optimizing of surface treatments to extend the lifespan and performance of medium-carbon steels in industrial use. Full article

X5CrNi18-10 is a corrosion-resistant steel that has become popular in the automotive, marine, food, nuclear, and other industries. Chromium alloyed in the X5CrNi18-10 increases the material’s toughness, which influences the cutting phenomena such as the cutting force and vibration. It is necessary to investigate the effect of the machining parameters on the X5CrNi18-10 turning, particularly the feed, which has significant effects on the cutting phenomena. The objective of this research is to investigate the correlation between the feed and cutting phenomena to improve the product quality, reduce machining disruptions, and optimize the parameters for a low cutting speed and vibration. Statistical analysis has shown promise in identifying the impact of variables using correlation analysis and estimated marginal means plots. This study highlights the findings of the Pearson’s correlation analysis between the feed, active cutting force, and active vibration as well as the estimated marginal means plots between the machining parameters and cutting phenomena. The results indicate that there is a strong correlation between the feed and active cutting force with a coefficient of correlation of 0.688, as well as the feed and active vibration with a coefficient of correlation of 0.697. The estimated marginal means plots indicate that as the cutting speed increases, the value of the active vibration and the active force decreases. Full article

Polycyclic aromatic hydrocarbons (PAHs) are considered hazardous pollutants due to their negative impact on the environment and human health. PAHs can accumulate and be retained in the soil, so PAH pollution is a worldwide problem. This review paper highlights the sources of PAH soil pollution, factors affecting the bioavailability of PAHs in soil, and soil bioremediation methods, as well as the advantages and limitations of the application of these methods. Aspects regarding the impact of the application of surfactants are presented in order to obtain good bioavailability during PAH bioremediation. Bioremediation techniques of soil polluted by these hydrocarbons are addressed: phytoremediation, rhizoremediation, composting, vermiremediation, micoremediation, and electrokinetic bioremediation of PAH-polluted soils. A comprehensive overview of bioremediation technologies for PAH-polluted soils is needed so that the right soil remediation technology is chosen. It has been observed the bioremediation of contaminated soils through rhizoremediation proved to be an effective process, the future of organic pollutants in interaction with plants and microbes must be researched. Vermiremediation, electrokinetic bioremediation, and microcomposting are effective processes for treating soils in situ. Phytoremediation is a sustainable and ecological method of PAH depollution. It improves soil fertility by releasing different organic matter in the soil, and it can be applied on a large scale. Full article

Sustainable urban development requires good interaction between water, energy, infrastructure and socio-economic areas. In the context of more frequent heavy rainfall and flooding events, managing the subsystems within the city in an integrated manner and realizing sustainable development have become popular research topics. Based on the above analysis, this paper constructs a water, energy, industry and economic growth system. It also introduces rainfall as an exogenous variable into the model in order to simulate the process of interactions between subsystems within a city and achieve sustainable development. By measuring the dynamic changes and spatial distribution characteristics of the efficiency values of the total water–energy–industry and economic growth system and each subsystem in 29 provinces in China, the following conclusions are drawn: (1) Most of the provinces are in the situation of “high-efficiency–negative growth” or “low-efficiency–positive growth”, and the constraints for them to reach the state of “high efficiency–positive growth” are due to the water subsystem. (2) The low-efficiency provinces are mainly concentrated in the central region, and the spillover effect of the low-efficiency provinces on the neighboring regions is more notable than that of the high-efficiency provinces. (3) The addition of rainfall improves the total efficiency in most provinces, with the most obvious improvement in the efficiency of the water subsystem. (4) The efficiency value of the industry and economic growth subsystem is relatively less affected by the amount of rainfall, but excessive rainfall will also have a negative impact. Finally, relevant policy recommendations are made to inform the relevant government departments in formulating policies related to addressing climate change and achieving sustainable urban development. Full article

Building on the extant literature and utilizing data from the EU-SILC and the EU-LFS surveys conducted between 2009 and 2023, we empirically investigate the impact of poor employment conditions—associated with insecure or precarious employment—on third-country nationals’ (TCNs’) self-perceived health status (SPH). The role of employment conditions in health is examined by employing indicators of temporary, part-time, and self-employment. Driven by theory and empirical analysis, we also investigate the effects of additional variables, including long-term unemployment. Finally, to probe differences across countries, we examine how the effects of employment conditions on TCNs’ health vary across institutional settings, namely across different types of welfare state. Descriptive statistics and regression analyses of panel data reveal that employment conditions affect immigrants’ SPH and surface significant differences across countries. The estimated country-specific effects point to statistical average differences between Germany and two groups of countries: one showing higher effects (i.e., Austria, Belgium, Denmark, Finland, and France) and another with lower effects (i.e., Greece, Ireland, Italy, and Spain). The welfare model adopted by different countries is a qualitative significant predictor of TCNs’ SPH. We conclude with a discussion of the implications of these findings for future research, but also policy initiatives to improve TCNs’ employment conditions and, consequently, their health and overall well-being. Full article

Prion diseases, including Creutzfeldt–Jakob disease (CJD), are deadly neurodegenerative disorders characterized by the buildup of abnormal prion proteins in the brain. This accumulation disrupts neuronal functions, leading to the rapid onset of psychiatric symptoms, ataxia, and cognitive decline. The urgency of timely diagnosis for effective treatment necessitates the identification of strongly correlated biomarkers in bodily fluids, which makes our research crucial. In this study, we employed a fully automated multiplex ELISA (Ella^®) to measure the concentrations of 14-3-3 protein, total tau protein, and neurofilament light chain (NF-L) in cerebrospinal fluid (CSF) and serum samples from patients with prion disease and analyzed their link to disease prognosis. However, in North American and European cases, we did not confirm a correlation between NF-L levels and survival time. This discrepancy is believed to stem from differences in treatment policies and measurement methods between Japan and the United States. Nonetheless, our findings suggest that NF-L concentrations could be an early diagnostic marker for CJD patients with further enhancements. The potential impact of our findings on the early diagnosis of CJD patients is significant. Future research should focus on increasing the number of sCJD cases studied in Japan and gathering additional evidence using next-generation measurement techniques. Full article

Discarded sports waste faces bottlenecks in application due to inadequate disposal measures, and there is often a neglect of enhancing resource utilization efficiency and minimizing environmental impact. In this study, nanoporous biochar was prepared through co-hydrothermal carbonization (co-HTC) and pyrolytic activation by using mixed goose feathers and heavy-metals-contaminated pine sawdust. Comprehensive characterization demonstrated that the prepared M-3-25 (Biochar derived from mixed feedstocks (25 mg/g Cu in pine sawdust) at 700 °C with activator ratios of 3) possesses a high specific surface area 2501.08 m² g⁻¹ and abundant heteroatomic (N, O, and Cu), exhibiting an outstanding physicochemical structure and ultrahigh electrochemical performance. Compared to nanocarbon from a single feedstock, M-3-25 showed an ultrahigh capacitance of 587.14 F g⁻¹ at 1 A g⁻¹, high energy density of 42.16 Wh kg⁻¹, and only 8.61% capacitance loss after enduring 10,000 cycles at a current density of 10 A g⁻¹, positioning M-3-25 at the forefront of previously known biomass-derived nanoporous carbon supercapacitors. This research not only introduces a promising countermeasure for the disposal of sports waste but also provides superior biochar electrode materials with robust supercapacitor characteristics. Full article

The Paris Agreement emphasizes the critical role of forests in addressing climate change and ecological protection. High-quality forestry development is an important aspect of forest conservation. As a core strategy for China’s economic transformation, new-type urbanization is increasingly interacting with high-quality forestry development. This study aims to explore this relationship and analyze its impact mechanism. Taking the representative Yellow River Basin in China as an example, this research uses a benchmark regression model, mediation effect model, and threshold effect model from 2010 to 2022 to quantitatively analyze the impact of new-type urbanization on high-quality forestry development. The results show that (1) new-type urbanization has significantly promoted high-quality forestry development, with an estimated coefficient of 0.325; (2) forestry in different regions exhibits significant differences, with the forestry return coefficients for the upper, middle, and lower reaches being 0.326, 0.213, and −0.359, respectively; (3) technological innovation plays a key role in improving forestry production efficiency, resource diversity, and ecosystem services, with an estimated coefficient of 6.543 for technological innovation; (4) the greater the government support, the larger the impact. The p-value of the double threshold is 0.037. Accordingly, to achieve high-quality forestry development, joint efforts are required at both the national and regional levels in promoting new-type urbanization. At the national level, specific ecological areas should be taken as units, and a collaborative development plan for new-type urbanization and high-quality forestry development should be formulated based on the land spatial planning system. This plan should clarify top policy objectives, set up special funds, establish long-term incentives and supervision mechanisms, and ensure that new urbanization has a positive impact on forestry development. At the regional level, appropriate technological innovations should be introduced based on local characteristics, and differentiated new-type urbanization development policies should be formulated to promote high-quality forestry development in the region. Full article

Mikania micrantha, one of the world’s most destructive invasive species, is known for causing significant ecological and economic harm. While extensive research has focused on its growth characteristics, secondary metabolites, and control measures, its chemical interactions with the environment—particularly the role of flavonoids in shaping soil microbial communities—remain underexplored. In this study, we identified and quantified ten flavonoids from M. micrantha root exudates using UPLC-MS, including Hispidulin, Isorhamnetin, and Mikanin. To examine their impact, crude flavonoid extracts were applied to soil in potted experiments, which demonstrated that these compounds significantly increased soil fungal diversity and boosted the relative abundance of arbuscular mycorrhizal fungi (AMF). Furthermore, KEGG pathway analysis revealed that flavonoid addition elevated the copy numbers of genes involved in nitrogen cycling and metabolic functions, enhancing nutrient availability and microbial activity. Additionally, crude flavonoid extracts promoted the relative abundance of beneficial soil bacteria, such as Achromobacter, as well as AMF, both of which contribute to nutrient acquisition, plant growth, and soil health. These findings indicate that M. micrantha’s flavonoids can alter soil microbial community composition, thereby creating a favorable environment that reinforces its competitive edge over native plants. Full article