Search Results (127,356)

In the natural environment, plants are simultaneously exposed to multivariable abiotic and biotic stresses. Typical abiotic stresses are changes in temperature, light intensity and quality, water stress (drought, flood), microelements availability, salinity, air pollutants, and others. Biotic stresses are caused by other organisms, such as pathogenic bacteria and viruses or parasites. This review presents the current state-of-the-art knowledge on programmed cell death in the cross-tolerance phenomena and its conditional molecular and physiological regulators, which simultaneously regulate plant acclimation, defense, and developmental responses. It highlights the role of the absorbed energy in excess and its dissipation as heat in the induction of the chloroplast retrograde phytohormonal, electrical, and reactive oxygen species signaling. It also discusses how systemic- and network-acquired acclimation and acquired systemic resistance are mutually regulated and demonstrates the role of non-photochemical quenching and the dissipation of absorbed energy in excess as heat in the cross-tolerance phenomenon. Finally, new evidence that plants evolved one molecular system to regulate cell death, acclimation, and cross-tolerance are presented and discussed. Full article

Objectives: The immune-enhancing properties of steamed mature silkworm, known as HongJam (HJ), were investigated using human interleukin-2-independent Natural Killer 92 (NK92-MI) cells and a cyclophosphamide intraperitoneal injection-induced immunosuppressed mice model (CPA-IP). White Jade variety mature silkworm HJ (WJ-HJ) was used to prepare WJ-HJ supercritical fluid extracts (WJ-SCE) and WJ-HJ-supplemented feeds. Results: Treatment with WJ-SCE significantly enhanced proliferation, migration, and cytotoxicity of NK92-MI cells against various cancer cells while improving mitochondrial function and ATP production (p < 0.05). In CPA-IP mice, consumption of WJ-HJ-supplemented feeds restored immune function by improving body weight, immune organ indices, immunoglobulin levels, and blood cytokines. Splenocyte proliferation and cytotoxicity were significantly elevated in both saline intraperitoneal injection (Sal-IP) and CPA-IP groups with WJ-HJ supplementation, independent of mitogen activation (p < 0.05). Conclusions: These results suggest that WJ-HJ enhances immune modulation and immune surveillance functions of NK cells by improving mitochondrial and cytotoxic functions. WJ-HJ holds promise as a functional food for immune enhancement, pending clinical validation. Full article

Abstract: The buildup of abandoned plastics in the environment and the need to optimize agricultural waste utilization have garnered scrutiny from environmental organizations and policymakers globally. This study presents an assessment of the thermal decomposition of date seeds (DS), polypropylene homopolymer (PP), and their composites (DS/PP) through experimental measurements, machine learning convolutional deep neural networks (CDNN), and kinetic and thermodynamic analyses. The experimental measurements involved the pyrolysis and co-pyrolysis of these materials in a nitrogen-filled thermogravimetric analyzer (TGA), investigating degradation temperatures between 25 and 600 °C with heating rates of 10, 20, and 40 °C.min⁻¹. These measurements revealed a two-stage process for the bio-composites and a decrease in the thermal stability of pure PP due to the moisture, hemicellulose, and cellulose content of the DS material. By utilizing machine learning CDNN, algorithms and frameworks were developed, providing responses that closely matched () the experimental data. After various modelling modifications, adjustments, and regularization techniques, a framework comprising four hidden neurons was determined to be most effective. Furthermore, the analysis revealed that temperature was the most influential parameter affecting the thermal decomposition process. Kinetic and thermodynamic analyses were performed using the Coats–Redfern and general Arrhenius model-fitting methods, as well as the Flynn–Wall–Ozawa and Kissinger–Akahira–Sunose model-free approaches. The first-order reaction mechanism was identified as the most appropriate compared to the second and third order F-Series solid-state reaction mechanisms. The overall activation energy values were estimated at 51.471, 51.221, 156.080, and 153.767 kJ·mol⁻¹ for the respective kinetic models. Additionally, the kinetic compensation effect showed an exponential increase in the pre-exponential factor with increasing activation energy values, and the estimated thermodynamic parameters indicated that the process is endothermic, non-spontaneous, and less disordered. Full article

Azulene-based polycyclic hydrocarbons have garnered much attention as potential materials for organic optoelectronic devices and as molecular models for graphene nanosheets with structural defects. Although various methods for ring fusions to an azulene core have been established for ring fusions to an azulene core, efficient synthetic methodologies for ortho- and peri-fusion to an azulene core are still lacking, which hinders the investigation of the effect of the ortho- and peri-fusion on the electronic properties of the embedded azulene core. Herein, we describe the synthesis and characterization of quinoxaline-fused cyclopenta[cd]azulene 4 as a new ortho- and peri-fused azulene derivative. The target molecule 4 was successfully synthesized in four steps from 4-methylazulene. The ring annulation decreased the lowest excitation energy compared with that of azulene and its structural isomer 5 and led to multiple reversible reduction processes. Characterization of the molecular geometry and optoelectronic properties of 4 revealed that the embedded azulene core preserves its original aromaticity, while the fused quinoxaline acts as a nucleophilic and basic site. These features suggest that 4 could serve as a metal ligand, a near-infrared absorber, and a component in organic functional devices. Full article

Background: Vaccination is a proven and safe method for combating COVID-19; however, coverage remains low in many low- and middle-income countries, including Nigeria. There is also a lack of contextual evidence regarding the public perception of and willingness to receive vaccines. This study aims to contribute to efforts to optimize the vaccination coverage and improve public health in northern Nigeria. Objective: This study investigated the perceptions of COVID-19 vaccination and willingness to uptake the vaccine in northern Nigeria, aiming to identify strategies for optimizing coverage and enhancing vaccination rates. Methods: A cross-sectional household survey was conducted across the Federal Capital Territory and five northern states in Nigeria. The survey assessed the respondents’ perceptions of COVID-19, their knowledge of the COVID-19 vaccine, and their willingness to be vaccinated. Descriptive and inferential (multivariate logistic regression) statistical analyses were employed to characterize the population and identify predictors of vaccine uptake. Results: The mean age of the respondents was 28.00 years. The majority reported at least one piece of misinformation regarding COVID-19. While awareness of the vaccine was high, its actual uptake was low, and future willingness to receive the vaccine was also limited. Employment status emerged as a significant predictor of vaccine uptake, as determined through the multivariate analysis. Furthermore, collaboration with NGOs and community-based organizations (CBOs) was identified as the most effective strategy for enhancing vaccine uptake. Conclusions: This study found a concerningly low willingness to receive the COVID-19 vaccine among participants in northern Nigeria. To address this issue, we recommend establishing partnerships with NGOs and CBOs, implementing extensive public awareness campaigns, and conducting community outreach programs. These efforts should focus on dispelling misinformation, building community trust, and promoting vaccine uptake through culturally appropriate communication materials. Full article

This paper presents a systematic post-occupancy evaluation (POE) of a gated apartment building in Onaizah, Qassim, Saudi Arabia, focusing on resident satisfaction and building performance. Employing a mixed-methods approach, the research combines quantitative data from questionnaires and qualitative data from walkthrough observations and interviews to assess various performance aspects, including thermal comfort, visual comfort, acoustic performance, and safety. Results indicate that residents generally expressed satisfaction with thermal comfort, visual comfort, and indoor air quality. However, concerns were highlighted in areas such as safety and security, design adequacy, and construction support services. These findings reveal that while the building meets many occupant needs, there are critical areas requiring improvement. This study underscores the importance of incorporating POE as a valuable tool for assessing building performance and informing future design and management strategies in residential developments. Finally, this study’s methodology excelled in analyzing the quality and performance of residential building elements, which contributes to enriching the literature related to facilities management. It explains the research strategy followed to provide an organized and reliable framework that can be used to evaluate performance and quality in residential buildings. Full article

The Organic Rankine Cycle (ORC) is an effective method for transforming low- and medium-grade heat into electricity that has recently gained significant attention. Several review studies in the literature are focused on working fluids, system architecture, and the individual utilization of renewable and alternative heat sources in ORCs, like solar irradiation, geothermal, biomass, and waste heat energy. However, no studies have yet investigated ORC systems driven by two of the aforementioned sources combined. This work aims to review and explore multiple aspects of hybrid ORC systems. Such systems are categorized based on source combinations and configurations, and the results regarding their thermodynamic, thermo-economic, and environmental performance are discussed. The source arrangements follow the following three main configurations: series, parallel, and heat upgrade. Most of the examined systems include solar energy as one of the sources and only four cases involve combinations of the other three sources. The reported results show that hybrid ORCs generally perform better thermodynamically compared to their respective single-source systems, exhibiting an enhancement in power production that reaches 44%. An average levelized cost of energy (LCOE) of 0.165 USD/kWh was reported for solar–geothermal plants, 0.153 USD/kWh for solar–biomass plants, and 0.100 USD/kWh for solar–waste plants. Solar–biomass plants also reported the lowest reported LCOE value of 0.098 USD/kWh. The payback periods ranged from 2.88 to 10.5 years. Further research is proposed on multiple source combinations, the in-depth analysis of the three main configurations, the integration of polygeneration systems, the incorporation of zeotropic mixture working media and experimental research on ORCs with combined sources. Full article

Ionizing radiation is a health threat to many, including warfighters, radiological emergency responders, radiotherapy patients, and astronauts. Despite this, no FDA-approved prophylactic medical countermeasures exist to attenuate the symptoms that occur from radiation exposure. Manganese has recently been shown to be critical for radioresistance in a wide range of organisms. In this study, we designed a stringent feeding method to test the prophylactic effects of dietary manganese on Drosophila’s lifespan before exposure to acute irradiation. We found that male flies have substantially lower radioresistance than females, but feeding with low doses of MnCl₂ before acute irradiation exposure extends male survival to that of females. Whole animal electron paramagnetic resonance analyses showed males have lower amounts of high-symmetry manganese-metabolite antioxidant complexes (H-Mn) than females, but manganese supplementation increases H-Mn to female levels. Levels of mitochondrial free-radical scavenger manganese-superoxide-dismutase 2 (MnSOD2) did not increase after acute irradiation, nor did loss of MnSOD2 sensitize larvae to acute irradiation exposure. These data support that prophylactic manganese feeding is sufficient to increase survivorship in males subjected to acute irradiation, independent of MnSOD2 levels, indicating a role of antioxidant manganese-metabolite H-Mn complexes for radioprotection. Furthermore, this Drosophila feeding method could be used to identify additional radiation countermeasures. Full article

The agricultural sector faces significant pressure to meet the growing global demand for food while managing the planet’s limited natural resources. Addressing this challenge requires the strategic use of abundant materials and accessible biotechnologies that farmers can effectively implement. This study evaluated the effects of various substrate mixtures, including combinations of coconut fiber with compost or vermicompost (50:50 v/v). It also assessed the impact of heat treatment and inoculation with the antagonist Trichoderma asperellum on the production of basic potato seeds grown in 70 L plastic baskets. Statistical analysis revealed that the vermicompost-based mixture outperformed others, demonstrating superior biometric variables for potato plants. The treatment with sterilized vermicompost led to a 41% increase in seed weight, underscoring the beneficial effects of vermicompost. Correlation analysis indicated a positive relationship between the phosphorus content of the mixture and a negative relationship with the E4/E6 ratio—a parameter recognized as a reliable and easily measurable indicator of substrate quality, along with pH and electrical conductivity. Full article

Ulcerous lesions can arise in primary skin cancers and upon infiltration of the skin by malignant cells originating from other organs. These malignant fungating wounds are difficult to treat, and they cause pain, itching and malodor. Distressing malodor imposes a major burden on patients. The carrion odor of decaying tissue is—at least in part—due to the bacterial breakdown products cadaverine and putrescine. Here, we examined the binding of cadaverine, histamine, putrescine, spermidine and spermine to the preparation of micronized purified clinoptilolite-tuff (PCT) by relying on three radiolabeled tracers ([³H]cadaverine, [³H]histamine and [³H]spermidine). Binding was rapid, stable and of high capacity. The binding affinities were in the low µM range. Displacement experiments indicated that the binding sites were non-equivalent. These three properties combined to support effective binding for any given ligand in the presence of the expected, submillimolar concentrations of competing ligands. This was further verified by measuring the binding of [³H]cadaverine in the presence of wound drainage fluids. [³H]Cadaverine was effectively adsorbed by a wound dressing, into which purified clinoptilolite-tuff had been incorporated: the observed binding capacity of this wound dressing was consistent with its content of purified clinoptilolite-tuff. Based on these findings, we propose that purified clinoptilolite-tuff be further investigated as a means to control malodor emanating from chronic wounds. Full article

Metal–organic frameworks (MOFs) with redox metal centers have come into view as potential materials for electrochemical energy storage. However, the poor electrical conductivity largely impedes the potentiality of MOFs to construct high-performance electrodes in supercapacitors. In this work, a self-dissociation strategy has been applied to construct Ni-MOF microbelts on Ni foam (NF), where the NF is used as both a support and a Ni source. The transmission channels between the Ni-MOF and NF are favorable for the charge transport due to the in situ self-assembly of the TPA linkers with the dissociated Ni ions from the Ni foam. The grown Ni-MOF microbelt arrays can offer abundant active sites for redox reactions. The prepared Ni-MOF/NF-s electrode can yield a high capacitance of 1124 F g⁻¹ at 1 A g⁻¹ and retains 590 F g⁻¹ at 10 A g⁻¹. This design may offer a controllable protocol for the construction of MOF microbelt arrays on various metal substrates. Full article

Our health, well-being, and development are intrinsically linked to the preservation of biodiversity. This situation has driven the establishment of numerous treaties, international agreements, and regulatory frameworks that address sustainable food systems from multiple perspectives, including agriculture, food security, biodiversity, and environmental sustainability. The objective of this study is to review the potential of wild edible fruits in terms of sustainability and implications for human health. Specifically, this work examines the contribution of these fruits to promoting biodiversity, and their support for sustainable food systems as well as their beneficial role in human health. Additionally, it considers the evolution of relevant international treaties related to the preservation of wild fruits. An in-depth review of international treaties related to the conservation of wild fruits was conducted by consulting information available on official websites of international organizations such as the United Nations and the Food and Agriculture Organization of the United Nations (FAO), among others. Next, a review of the sustainability and health benefits of edible wild fruits was performed. Results showed that although numerous studies have demonstrated the health benefits of wild edible fruits, there is still a lack of scientific evidence showing that the use of these species could have positive effects not only on human health and well-being but also on the environment and biodiversity. Thus, integrating these fruits into sustainable practices could play a key role in supporting future food security and the well-being of communities. Full article

The available literature reports inconclusive findings regarding the frequency of organic food consumption and cancer incidence. This systematic review evaluated the effect of the frequency of organic food consumption on overall and site-specific cancer risk. Four electronic databases (PubMed, Scopus, Web of Science Core Collection, and Embase), the gray literature, and the reference lists of the included reports were searched for eligible studies. Study screening, data abstraction, and risk of bias assessment were performed by two independent examiners. Hazard ratios (HRs) and 95% confidence intervals using a random effects model were utilized to synthesize the available data from the included studies. There was no difference between the two interventions regarding overall cancer (HR = 0.93, 95% CI: 0.78–1.12), breast cancer (HR = 1.01, 95% CI: 0.81–1.26), colorectal cancer (HR = 1.01, 95% CI: 0.93–1.10), and non-Hodgkin lymphoma risks (HR = 0.70, 95% CI: 0.17–2.94). The findings suggest that the overall and site-specific cancer risk are not associated with the frequency of consumption of organic foods. Further research is necessary to provide more evidence for the role of organic food consumption on the incidence of cancer using homogeneous methodologies to define the frequency of organic food consumption. Full article

A previous ethnobotanical investigation conducted in Valle Imagna (Northern Italy) highlighted the traditional use of Agrimonia eupatoria L. (Rosaceae) as a disinfectant and wound-healing agent. This use seemed to be linked to a local 18th century manuscript. This species was chosen for a multidisciplinary investigation to validate or refute its traditional use in the valley. Samples from fresh leaves were observed under Scanning Electron and Light Microscopy. The phenolic profiles of an epicuticular aqueous extract of the whole leaves and of infusions and decoctions of leaves and aerial parts were analyzed through Liquid Chromatography–Tandem Mass Spectrometry. The volatile organic compounds (VOCs) of fresh leaves were analyzed through Headspace Solid-Phase Microextraction coupled with Gas Chromatography–Mass Spectrometry. Growth inhibition and adhesion modulation were assessed on Escherichia coli, Staphylococcus aureus, and S. warneri by minimum inhibitory concentration and adhesion assays. Two trichome morphotypes were observed: a capitate with a one-celled rounded head and a capitate with a teo-celled cylindrical head. Both were responsible for producing terpenes, while the cylindrical capitates also produced polyphenols. Thirty-four phenolic compounds were characterized. Luteolin-7-O-glucoside, Catechin, and Epicatechin were common to all five extracts. The VOC profiles highlighted the dominance of (+)-α-Pinene. The infusions and the decoctions had a significant inhibitory activity on E. coli, and the extracts (specifically, the infusion of the leaves and both decoctions) also had a stimulating effect on the biofilm formation of S. warneri. These results already hold particular interest because of the strong connection they have to the traditional use of agrimony described in Valle Imagna. Full article

This study represents a pioneering initiative in the printing industry, especially in Poland, which assessed the environmental impacts and eco-efficiency of proof printing through the life cycle assessment (LCA) methodology. The process of proof printing on a target substrate was compared with the traditional hard proofing process, which requires trial printing in production conditions. The analysis adhered to the ISO 14040 and 14044 standards, assessing greenhouse gas (GHG) emissions, raw material use (e.g., plastics, water), and environmental toxicity. The innovative proofing on the target substrate process exhibits a lower environmental impact, as confirmed by the GHG emissions and plastic and water demand of the process. The GHG emissions were reduced from 2610 kg of CO₂e to 68.4 kg of CO₂e per functional unit (FU). The water demand for the proofing on the target substrate process was 40 times lower, and the plastic demand was also 40 times lower, decreasing to 20 kg per FU. The toxicity impact of the method based on the proofing system on the target substrate on living organisms is more than six times lower than that of the conventional method. The proof printing on the target substrate process offers an environmentally friendly alternative to the traditional hard proofing process, with lower GHG emissions and a lower environmental impact. Full article